Q9CNZ0 (SUCC_PASMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Succinyl-CoA ligase [ADP-forming] subunit beta
EC=6.2.1.5

Alternative name(s):
Succinyl-CoA synthetase subunit beta
Short name=SCS-beta

Gene names

Name:	sucC
Ordered Locus Names:	PM0280

Organism

Pasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]

Taxonomic identifier

272843 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	388 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + succinate + CoA = ADP + phosphate + succinyl-CoA. HAMAP MF_00558
Cofactor	Binds 1 magnesium or manganese ion per subunit By similarity.
Pathway	Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1. HAMAP MF_00558
Subunit structure	Heterotetramer of two alpha and two beta subunits By similarity.
Sequence similarities	Belongs to the succinate/malate CoA ligase beta subunit family. Contains 1 ATP-grasp domain.

Ontologies

Keywords
Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW succinate-CoA ligase (ADP-forming) activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 388	388	Succinyl-CoA ligase [ADP-forming] subunit beta HAMAP MF_00558		PRO_0000102843
Regions
	Domain	9 – 244	236	ATP-grasp
	Nucleotide binding	35 – 108	74	ATP By similarity
Sites
	Metal binding	197	1	Magnesium or manganese By similarity
	Metal binding	199	1	Magnesium or manganese By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CNZ0 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: F550F3A4FC42BF9F	FASTA	388	41,494
	10 20 30 40 50 60 MNLHEYQAKQ IFAEYQLPVG KGYACKSADE AADAIKKLNG DVWVAKCQVH AGGRGKAGGV 70 80 90 100 110 120 KLVRNEAEVR AFADQWLGQR LVTFQTDVNG QPVNTLYVEE GSSIARELYL GAVLDRASQR 130 140 150 160 170 180 VVFMVSTEGG VNIEEVAEKT PHLLHKMAID PLTGGMPYQG RELAFKLGLK GDQIKQFAHI 190 200 210 220 230 240 FVQMAKMFVE KDLALLEVNP LVVTKEGNLL CLDAKIVVDS NALYRQPALK AMQDPSQEDP 250 260 270 280 290 300 REALAESHQL NYVALEGNIG CMVNGAGLAM GTMDIIKLHG GQPANFLDVG GGATKERVAE 310 320 330 340 350 360 AFKIILSDSA VKAVLVNIFG GIVRCDLIAE GIIAAVNEVG VNVPVVVRLE GNNAPLGREI 370 380 LANSGVNIIA ANTLTDAAIQ AVKAAEGK

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004439 Genomic DNA. Translation: AAK02364.1.
RefSeq	NP_245217.1. NC_002663.1.
3D structure databases
ProteinModelPortal	Q9CNZ0.
SMR	Q9CNZ0. Positions 1-388.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1243627.
GenomeReviews	Gene locus PM0280 in contig AE004439_GR.
KEGG	pmu:PM0280.
NMPDR	fig|272843.1.peg.280.
PATRIC	22869714. VBIPasMul88067_0289.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG315432.
OMA	QIKQFAH.
ProtClustDB	PRK00696.
Enzyme and pathway databases
BioCyc	PMUL272843:PM0280-MONOMER.
Family and domain databases
HAMAP	MF_00558. Succ_CoA_beta. [Tree]
InterPro	IPR011761. ATP-grasp. IPR013650. ATP-grasp_succ-CoA_synth-type. IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR005811. CoA_ligase. IPR017866. Succ-CoA_synthase_bsu_CS. IPR005809. Succ_CoA_synthase_bsu. IPR016102. Succinyl-CoA_synth-like. [Graphical view]
Gene3D	G3DSA:3.30.1490.20. ATP_grasp_subdomain_1. 1 hit. G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.261. Succinyl-CoA_synth-like. 1 hit.
KO	K01903.
PANTHER	PTHR11815. CoA_lig_beta. 1 hit.
Pfam	PF08442. ATP-grasp_2. 1 hit. PF00549. Ligase_CoA. 1 hit. [Graphical view]
PIRSF	PIRSF001554. SucCS_beta. 1 hit.
SUPFAM	SSF52210. CoA_ligase. 1 hit.
TIGRFAMs	TIGR01016. SucCoAbeta. 1 hit.
PROSITE	PS50975. ATP_GRASP. 1 hit. PS01217. SUCCINYL_COA_LIG_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

SUCC_PASMU

Accession

Primary (citable) accession number: Q9CNZ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 27, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program