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Q9CNU2 (NADK_PASMU) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:PM0333
OrganismPasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]
Taxonomic identifier272843 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella

Protein attributes

Sequence length305 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 305305NAD kinase HAMAP-Rule MF_00361
PRO_0000120644

Regions

Nucleotide binding84 – 852NAD By similarity
Nucleotide binding159 – 1602NAD By similarity
Nucleotide binding200 – 2056NAD By similarity

Sites

Active site841Proton acceptor By similarity
Binding site1701NAD By similarity
Binding site1871NAD By similarity
Binding site1891NAD By similarity
Binding site2601NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CNU2 [UniParc].

Last modified May 4, 2001. Version 1.
Checksum: BD8BC03D93C41BE6

FASTA30533,711
        10         20         30         40         50         60 
MKHPNTIDIK ALQSSFQIIG LLGKPRHDVT LQMHKNLFQW LLEKGYQVLV ERPIGEQLGL 

        70         80         90        100        110        120 
SENYLASVDE IGQQAQLAIV IGGDGNVLGR ARTLAKYDIA LIGINRGNLG FLTDIDPKNA 

       130        140        150        160        170        180 
YSQLQACLED GDCFVEERFI LEASVERNGK IIARGNAVNE AVVHPAKIAH MIDFHVYIND 

       190        200        210        220        230        240 
KFAFSQRSDG LIISTPTGST AYSLSAGGPI LTPQLNAIAL VPMFPHTLSS RPLVIDGDSK 

       250        260        270        280        290        300 
ISIRFAEYNT SQLEVGCDSQ VALEFSPDDI VHIQKSPDKL RLLHLKNYNY YKVLSSKLGW 


LRNSV 

« Hide

References

[1]"Complete genomic sequence of Pasteurella multocida Pm70."
May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pm70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004439 Genomic DNA. Translation: AAK02417.1.
RefSeqNP_245270.1. NC_002663.1.

3D structure databases

ProteinModelPortalQ9CNU2.
SMRQ9CNU2. Positions 16-302.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272843.PM0333.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK02417; AAK02417; PM0333.
GeneID1243680.
KEGGpmu:PM0333.
PATRIC22869840. VBIPasMul88067_0346.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000227221.
KOK00858.
OMATHEMLYH.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycPMUL272843:GC8W-343-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_PASMU
AccessionPrimary (citable) accession number: Q9CNU2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: May 4, 2001
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families