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Protein

Glucose-6-phosphate isomerase

Gene

pgi

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-glucose 6-phosphate = D-fructose 6-phosphate.

Pathway: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Glucose-6-phosphate isomerase (pgi)
  3. ATP-dependent 6-phosphofructokinase (pfkA)
  4. no protein annotated in this organism
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei355 – 3551Proton donorBy similarity
Active sitei387 – 3871By similarity
Active sitei515 – 5151By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Gluconeogenesis, Glycolysis

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-427-MONOMER.
UniPathwayiUPA00109; UER00181.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate isomerase (EC:5.3.1.9)
Short name:
GPI
Alternative name(s):
Phosphoglucose isomerase
Short name:
PGI
Phosphohexose isomerase
Short name:
PHI
Gene namesi
Name:pgi
Ordered Locus Names:PM0416
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Glucose-6-phosphate isomerasePRO_0000180700Add
BLAST

Proteomic databases

PRIDEiQ9CNL2.

Interactioni

Protein-protein interaction databases

STRINGi272843.PM0416.

Structurei

3D structure databases

ProteinModelPortaliQ9CNL2.
SMRiQ9CNL2. Positions 7-549.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GPI family.Curated

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CNL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKNINPTTTN AWKALQQHHK TQSAVTIQQL FAQEKDRFTD YSLSFNNEVL
60 70 80 90 100
VDFSKNNVTK ETLGLLRQLA QECALSEAVD AMFSGAKINK TEDRAVLHTA
110 120 130 140 150
LRNRSNSPVL VDGKDVMPEV NAVLAKMKDF CHRVISGEWK GYTGKAITDV
160 170 180 190 200
VNIGIGGSDL GPYMVTEALR PYKNHLNLHF VSNVDGTHIA ETLKKVNPET
210 220 230 240 250
TLFLVASKTF TTQETMTNAH SARNWFLATA KDESHVAKHF AALSTNSKAV
260 270 280 290 300
AEFGIDTNNM FEFWDWVGGR YSLWSAIGLS IALSIGFEHF EALLAGAHEM
310 320 330 340 350
DKHFRTAPIE QNIPTTLALI GLWNTNFLGA QTEAILPYDQ YLHRFAAYFQ
360 370 380 390 400
QGNMESNGKY VDRNGEVIDN YQTGPIIWGE PGTNGQHAFY QLIHQGTTLI
410 420 430 440 450
PCDFIAPAQT HNPLADHHEK LLSNFFAQTE ALAFGKTKEE VEAEFVKAGK
460 470 480 490 500
SLDEVKEVVP FKVFTGNKPT NSILVQKITP FTLGALIAMY EHKIFVQGVM
510 520 530 540
FNIYSFDQWG VELGKQLANR ILPELANRET ITTHDSSTNG LINQYKQWR
Length:549
Mass (Da):61,438
Last modified:June 1, 2001 - v1
Checksum:iE6E4856927B93283
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK02500.1.
RefSeqiNP_245353.1. NC_002663.1.
WP_005726133.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK02500; AAK02500; PM0416.
GeneIDi1243763.
KEGGipmu:PM0416.
PATRICi22870006. VBIPasMul88067_0428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK02500.1.
RefSeqiNP_245353.1. NC_002663.1.
WP_005726133.1. NC_002663.1.

3D structure databases

ProteinModelPortaliQ9CNL2.
SMRiQ9CNL2. Positions 7-549.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272843.PM0416.

Proteomic databases

PRIDEiQ9CNL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK02500; AAK02500; PM0416.
GeneIDi1243763.
KEGGipmu:PM0416.
PATRICi22870006. VBIPasMul88067_0428.

Phylogenomic databases

eggNOGiCOG0166.
HOGENOMiHOG000261371.
KOiK01810.
OMAiCETQAML.
OrthoDBiEOG64R61J.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00181.
BioCyciPMUL272843:GC8W-427-MONOMER.

Family and domain databases

Gene3Di1.10.1390.10. 1 hit.
HAMAPiMF_00473. G6P_isomerase.
InterProiIPR001672. G6P_Isomerase.
IPR023096. G6P_Isomerase_C.
IPR018189. Phosphoglucose_isomerase_CS.
[Graphical view]
PANTHERiPTHR11469. PTHR11469. 1 hit.
PfamiPF00342. PGI. 1 hit.
[Graphical view]
PRINTSiPR00662. G6PISOMERASE.
PROSITEiPS00765. P_GLUCOSE_ISOMERASE_1. 1 hit.
PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit.
PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.

Entry informationi

Entry nameiG6PI_PASMU
AccessioniPrimary (citable) accession number: Q9CNL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: June 1, 2001
Last modified: May 27, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.