true2002-08-132024-03-27134GLND_PASMUComplete genomic sequence of Pasteurella multocida Pm70.May B.J.Zhang Q.Li L.L.Paustian M.L.Whittam T.S.Kapur V.doi:10.1073/pnas.0516345982001Proc. Natl. Acad. Sci. U.S.A.983460-3465NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Pm70ACT_ACR-UUR-like_2ACT_UUR-like_1HDcNT_GlnE_GlnD_likeHypothetical protein af1432PII_uridylyl_transfACT-like_dom_sfACT_domHD/PDEase_domHD_domainNT_sfPII_UdlTrfase/GS_AdlTrfaseUTase/URUTase_glnDBIFUNCTIONAL URIDYLYLTRANSFERASE/URIDYLYL-REMOVING ENZYMEBIFUNCTIONAL URIDYLYLTRANSFERASE_URIDYLYL-REMOVING ENZYMEACTGlnD_UR_UTaseHDPII_uridyltransfHDcACT-likeHD-domain/PDEase-likeNucleotidyltransferaseNucleotidyltransferase substrate binding subunit/domainACTHDBifunctional uridylyltransferase/uridylyl-removing enzymeUTase/URBifunctional [protein-PII] modification enzymeBifunctional nitrogen sensor protein[Protein-PII] uridylyltransferasePII uridylyltransferaseUTase2.7.7.59[Protein-PII]-UMP uridylyl-removing enzymeUR3.1.4.-glnDPM0460Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.Uridylyltransferase (UTase) activity is inhibited by glutamine, while glutamine activates uridylyl-removing (UR) activity.Has four distinct domains: an N-terminal nucleotidyltransferase (NT) domain responsible for UTase activity, a central HD domain that encodes UR activity, and two C-terminal ACT domains that seem to have a role in glutamine sensing.Belongs to the GlnD family.Bifunctional uridylyltransferase/uridylyl-removing enzyme1007361864HD446562ACT 1687766ACT 2793Uridylyltransferase328Uridylyl-removing3296862001-06-011100736e3c50ec8f3153783a14d500961d6ef07MLFPYFPLSELDVSAVRTQKENLKQFELTQFAHYEIYDLITNRTQFCDHLLRDLWLRFGLVKDNTLTLIAVGGYGREEMFPLSDLDFLILTSEQVEAQTEQKIRQFVQFLWDCGFDVGHAVRTLSECEQAGRDNITVATNLLEARYLEGNFSQFQQLDNVLQKADFWPREAFFQAKYQERVERYQRYHNTSYNLEPDIKHSPGGLRDLHLLYWIALRHTGAKNLTDILNSGFIYPQEYAQLLESQQFLFKVRFALHLILKRYDNRLLFERQIRVAELLEFVGPGNQGVEKMMKSFFQALQTISLLSDLLVKHYREHFLQTNEPVQVRLLDKEFQCVNNAICLRQANLFVEQPEQILSLFFHLTQDHQLDIHSSTLRQLHLALEQRSGYLSELPVARERFLRLFNQPGAIARALVPMHKYGVLKAYLPQWHHIEGLMQFDLFHCYTVDEHIVRTLLKLEYFLEAESVVPHPICSQIFSRLTDRTLLYIAALFHDIAKGRGGDHAELGAVDVAQFAQQHGFDQREIHTLTWLVEQHLLMSVTAQRRDIHDPEVVLHFAEAVQNNVRLDYLTCLTVADICATNETLWNSWKRTLIATLYQFTTQQFAQGMDCLLDHAEKIENHRQQALTLLTQNSLLSAVQIEEIWQHCPEEYFLRNTPKQIAWHTELLADNQTELLVKISNRFSEGGTEIFVYCQDQPNLFHKVVTTIGAKKFSIHDAQIITSHDGYVFDSFIITELDGKLVKFDRRRSLEKALMQALNTSKLPTFRATDNPKLQHFHVKTEVRFLKEQRTDQTEMELFALDQTGLLAKVSQVFSELKLNLLNAKITTIGEKAEDFFILTNSEDRALTAEQRQCLTQRLHEVLEPKtruetrue