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Q9CNC4 (LST_PASMU) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase

Short name=Alpha 2,3-ST
Short name=Beta-galactoside alpha-2,3-sialyltransferase
EC=2.4.99.-
Alternative name(s):
Lipooligosaccharide sialyltransferase
Gene names
Name:lst
Ordered Locus Names:PM0508
OrganismPasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]
Taxonomic identifier272843 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D-glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide.

Catalytic activity

CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.

Pathway

Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.

Sequence similarities

Belongs to the glycosyltransferase 52 family.

Ontologies

Keywords
   Biological processLipopolysaccharide biosynthesis
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processlipopolysaccharide biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functiontransferase activity, transferring glycosyl groups

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase
PRO_0000080575

Sequences

Sequence LengthMass (Da)Tools
Q9CNC4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: E56E923367EB22C7

FASTA30835,724
        10         20         30         40         50         60 
MNLIICCTPL QVLIAEKIIA KFPHMPFYGV MLSTVSNKKF DFYAKRLAQQ CQGFFSMVQH 

        70         80         90        100        110        120 
KDRFNLLKEI LYLKRTFSGK HFDQVFVANI NDLQIQFLLS AIDFNLLNTF DDGTINIVPN 

       130        140        150        160        170        180 
SLFYQDDPAT LQRKLINVLL GNKYSIQSLR ALSHTHYTIY KGFKNIIERV EPIELVAADN 

       190        200        210        220        230        240 
SEKVTSAVIN VLLGQPVFAE DERNIALAER VIKQFNIHYY LPHPREKYRL AQVNYIDTEL 

       250        260        270        280        290        300 
IFEDYILQQC QTHKYCVYTY FSSAIINIMN KSDNIEVVAL KIDTENPAYD ACYDLFDELG 


VNVIDIRE 

« Hide

References

[1]"Complete genomic sequence of Pasteurella multocida Pm70."
May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V.
Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Pm70.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE004439 Genomic DNA. Translation: AAK02592.1.
RefSeqNP_245445.1. NC_002663.1.

3D structure databases

ModBaseSearch...

Protein family/group databases

CAZyGT52. Glycosyltransferase Family 52.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1243855.
GenomeReviewsGene locus PM0508 in contig AE004439_GR.
KEGGpmu:PM0508.
NMPDRfig|272843.1.peg.508.
PATRIC22870196. VBIPasMul88067_0514.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG495263.
OMAERIMAQH.
ProtClustDBCLSK870133.

Enzyme and pathway databases

BioCycPMUL272843:PM0508-MONOMER.

Family and domain databases

InterProIPR012477. Glyco_transf_52.
[Graphical view]
KOK00785.
PfamPF07922. Glyco_transf_52. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLST_PASMU
AccessionPrimary (citable) accession number: Q9CNC4
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families