Reviewed, UniProtKB/Swiss-Prot Q9CNC4 (LST_PASMU)

Names and origin

Protein names

Recommended name:
    CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase
      Short name=Beta-galactoside alpha-2,3-sialyltransferase
      Short name=Alpha 2,3-ST
    EC=2.4.99.-
Alternative name(s):
    Lipooligosaccharide sialyltransferase

Gene names

Name:	lst
Ordered Locus Names:	PM0508

Organism

Pasteurella multocida [Complete proteome] [HAMAP]

Taxonomic identifier

747 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	308 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D-glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide.
Catalytic activity	CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine.
Pathway	Bacterial outer membrane biogenesis; lipopolysaccharide biosynthesis.
Sequence similarities	Belongs to the glycosyltransferase 52 family.

Ontologies

Keywords
Biological process	Lipopolysaccharide biosynthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sialyltransferase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 308	308	CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase		PRO_0000080575

Sequences

	Sequence		Length	Mass (Da)
	Q9CNC4-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: E56E923367EB22C7	FASTA	308	35,724
	10 20 30 40 50 60 MNLIICCTPL QVLIAEKIIA KFPHMPFYGV MLSTVSNKKF DFYAKRLAQQ CQGFFSMVQH 70 80 90 100 110 120 KDRFNLLKEI LYLKRTFSGK HFDQVFVANI NDLQIQFLLS AIDFNLLNTF DDGTINIVPN 130 140 150 160 170 180 SLFYQDDPAT LQRKLINVLL GNKYSIQSLR ALSHTHYTIY KGFKNIIERV EPIELVAADN 190 200 210 220 230 240 SEKVTSAVIN VLLGQPVFAE DERNIALAER VIKQFNIHYY LPHPREKYRL AQVNYIDTEL 250 260 270 280 290 300 IFEDYILQQC QTHKYCVYTY FSSAIINIMN KSDNIEVVAL KIDTENPAYD ACYDLFDELG VNVIDIRE

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE004439 Genomic DNA. Translation: AAK02592.1.
RefSeq	NP_245445.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	GT52. Glycosyltransferase Family 52.
Genome annotation databases
GeneID	1243855.
GenomeReviews	Gene locus PM0508 in contig AE004439_GR.
KEGG	pmu:PM0508.
NMPDR	fig|272843.1.peg.508.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9CNC4.
OMA	Q9CNC4. ERIMAQH.
Family and domain databases
InterPro	IPR012477. Glyco_transf_52. [Graphical view]
Pfam	PF07922. Glyco_transf_52. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LST_PASMU

Accession

Primary (citable) accession number: Q9CNC4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)