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Protein

Ribosomal RNA large subunit methyltransferase M

Gene

rlmM

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + cytidine(2498) in 23S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylcytidine(2498) in 23S rRNA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei194S-adenosyl-L-methionineUniRule annotation1
Binding sitei246S-adenosyl-L-methionineUniRule annotation1
Binding sitei266S-adenosyl-L-methionineUniRule annotation1
Binding sitei284S-adenosyl-L-methionineUniRule annotation1
Active sitei313Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase MUniRule annotation (EC:2.1.1.186UniRule annotation)
Alternative name(s):
23S rRNA (cytidine2498-2'-O)-methyltransferaseUniRule annotation
23S rRNA 2'-O-ribose methyltransferase RlmMUniRule annotation
Gene namesi
Name:rlmMUniRule annotation
Ordered Locus Names:PM0568
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000704111 – 365Ribosomal RNA large subunit methyltransferase MAdd BLAST365

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi272843.PM0568.

Structurei

3D structure databases

ProteinModelPortaliQ9CN71.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni227 – 230S-adenosyl-L-methionine bindingUniRule annotation4

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105EZ6. Bacteria.
COG2933. LUCA.
HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M. 1 hit.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
IPR005100. TF_Spt5_NGN-domain.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
PF03439. Spt5-NGN. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CN71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKLALYCRP GFEKELAAEI SEKAAELGIF GFARVEENQG YVIFECYQTD
60 70 80 90 100
DADRLAREIP FNQLIFARQM IVVSDLLTDL PVQDRISPII QQYQAIAHQI
110 120 130 140 150
NLTYSTELLV ETADTNEAKS LSAFCRKFTV PLRQALKKQG WLQGTRHHKQ
160 170 180 190 200
GLTLHILMLD STQCYVGYSY NYNHSEHFMG IPRLKFPLDA PSRSTLKLEE
210 220 230 240 250
AILTFLSREE EKKRLNEQMY AVDLGACPGG WTYQLVKRGL FVYAVDHGKM
260 270 280 290 300
AASLHDTGRI EHCAEDGFKF QPPKRSKIDW LVCDMVEQPS RISQLILKWL
310 320 330 340 350
VNGWCHETIF NLKLPMKKRY LEVKKCLQMI EESLEKQGFR YHIQAKHLYH
360
DREEITVHIA VKSLD
Length:365
Mass (Da):42,289
Last modified:June 1, 2001 - v1
Checksum:i435A5BF655FBA52F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK02652.1.
RefSeqiWP_010906728.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK02652; AAK02652; PM0568.
GeneIDi1243915.
KEGGipmu:PM0568.
PATRICi22870318. VBIPasMul88067_0575.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK02652.1.
RefSeqiWP_010906728.1. NC_002663.1.

3D structure databases

ProteinModelPortaliQ9CN71.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272843.PM0568.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK02652; AAK02652; PM0568.
GeneIDi1243915.
KEGGipmu:PM0568.
PATRICi22870318. VBIPasMul88067_0575.

Phylogenomic databases

eggNOGiENOG4105EZ6. Bacteria.
COG2933. LUCA.
HOGENOMiHOG000247137.
KOiK06968.
OMAiVIFECYQ.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01551. 23SrRNA_methyltr_M. 1 hit.
InterProiIPR002877. rRNA_MeTrfase_FtsJ_dom.
IPR011224. rRNA_MeTrfase_M.
IPR029063. SAM-dependent_MTases.
IPR005100. TF_Spt5_NGN-domain.
[Graphical view]
PfamiPF01728. FtsJ. 1 hit.
PF03439. Spt5-NGN. 1 hit.
[Graphical view]
PIRSFiPIRSF028774. UCP028774. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRLMM_PASMU
AccessioniPrimary (citable) accession number: Q9CN71
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.