Q9CMX5 (NAGK_PASMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-D-glucosamine kinase
EC=2.7.1.59

Alternative name(s):
GlcNAc kinase

Gene names

Name:	nagK
Ordered Locus Names:	PM0675

Organism

Pasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]

Taxonomic identifier

272843 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella › Pasteurella multocida › Pasteurella multocida subsp. multocida

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P By similarity. HAMAP-Rule MF_01271
Catalytic activity	ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate. HAMAP-Rule MF_01271
Pathway	Cell wall biogenesis; peptidoglycan recycling. HAMAP-Rule MF_01271
Sequence similarities	Belongs to the ROK (NagC/XylR) family. NagK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Ligand	ATP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	N-acetylglucosamine metabolic process Inferred from electronic annotation. Source: HAMAP peptidoglycan turnover Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP N-acetylglucosamine kinase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	N-acetyl-D-glucosamine kinase HAMAP-Rule MF_01271		PRO_0000270109
Regions
	Nucleotide binding	4 – 11	8	ATP Potential
	Nucleotide binding	133 – 140	8	ATP Potential
Sites
	Metal binding	157	1	Zinc By similarity
	Metal binding	178	1	Zinc By similarity
	Metal binding	180	1	Zinc By similarity
	Metal binding	185	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CMX5 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 9E6A87AF91ABF786	FASTA	304	33,039
	10 20 30 40 50 60 MRYGFDIGGT KIELAVFNDQ LEKQYSERVE TPKESYEEWL NTIVRLVHKA DEMFQCQGTV 70 80 90 100 110 120 GLGIPGFVNP ATGIAEIVNI RAADHKPIIQ DLETRLGREV RAENDANCFA LSEAWDEENA 130 140 150 160 170 180 QYPSVLGLIL GTGFGGGLIF NGKVHSGQTG MAGEVGHTQL NYHALRLLGG DNAPIYDCGC 190 200 210 220 230 240 GNRACLDTYL SGRGFEMLYR DMQGEALSAQ AIIQRFYAGD QSAVKFVELF IELCAISIGN 250 260 270 280 290 300 LITVLDPHVI VLGGGLSNFD YLYEALPKAL PARLLRSANV PLIKKAKYGD SGGVRGAAAL FLSK

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004439 Genomic DNA. Translation: AAK02759.1.
RefSeq	NP_245612.1. NC_002663.1.
3D structure databases
ProteinModelPortal	Q9CMX5.
ModBase	Search...
Protein-protein interaction databases
STRING	272843.PM0675.
Proteomic databases
PRIDE	Q9CMX5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAK02759; AAK02759; PM0675.
GeneID	1244022.
KEGG	pmu:PM0675.
PATRIC	22870538. VBIPasMul88067_0684.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1940.
HOGENOM	HOG000150087.
KO	K00884.
OMA	IELAVFN.
ProtClustDB	PRK13310.
Enzyme and pathway databases
BioCyc	PMUL272843:GC8W-697-MONOMER.
UniPathway	UPA00544.
Family and domain databases
HAMAP	MF_01271. GlcNAc_kinase.
InterPro	IPR023505. N-acetyl-D-glucosamine_kinase. IPR000600. ROK. [Graphical view]
Pfam	PF00480. ROK. 1 hit. [Graphical view]
PROSITE	PS01125. ROK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NAGK_PASMU

Accession

Primary (citable) accession number: Q9CMX5

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	June 1, 2001
Last modified:	May 29, 2013
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program