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Protein

Chondroitin synthase

Gene

fcbD

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the polymerization of chondroitin, a polysaccharide composed of a repeating disaccharide of N-acetylgalactosamine (GalNAc) and glucuronic acid (GlcUA) units. Each unit has the composition in beta-(1->4)-GlcUA-beta-(1->3)-GalNAc.

Catalytic activityi

UDP-alpha-D-glucuronate + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-proteoglycan.
UDP-N-acetyl-alpha-D-galactosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan = UDP + N-acetyl-beta-D-galactosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-proteoglycan.

Cofactori

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.175. 4558.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Names & Taxonomyi

Protein namesi
Recommended name:
Chondroitin synthase
Short name:
CS
Including the following 2 domains:
Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase (EC:2.4.1.175)
Alternative name(s):
UDP-GalNAc transferase
N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase (EC:2.4.1.226)
Alternative name(s):
UDP-GlcUA transferase
Gene namesi
Name:fcbD
Ordered Locus Names:PM0775
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000592581 – 965Chondroitin synthaseAdd BLAST965

Interactioni

Protein-protein interaction databases

STRINGi272843.PM0775.

Structurei

3D structure databases

ProteinModelPortaliQ9CMP0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni145 – 318A1Add BLAST174
Regioni425 – 597A2Add BLAST173

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0726. LUCA.
HOGENOMiHOG000154388.
KOiK13500.
OMAiEVCICND.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 2 hits.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9CMP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTLSQAIKA YNSNDYELAL KLFEKSAETY GRKIVEFQII KCKEKLSTNS
60 70 80 90 100
YVSEDKKNSV CDSSLDIATQ LLLSNVKKLT LSESEKNSLK NKWKSITGKK
110 120 130 140 150
SENAEIRKVE LVPKDFPKDL VLAPLPDHVN DFTWYKNRKK SLGIKPVNKN
160 170 180 190 200
IGLSIIIPTF NRSRILDITL ACLVNQKTNY PFEVVVADDG SKENLLTIVQ
210 220 230 240 250
KYEQKLDIKY VRQKDYGYQL CAVRNLGLRT AKYDFVSILD CDMAPQQLWV
260 270 280 290 300
HSYLTELLED NDIVLIGPRK YVDTHNITAE QFLNDPYLIE SLPETATNNN
310 320 330 340 350
PSITSKGNIS LDWRLEHFKK TDNLRLCDSP FRYFSCGNVA FSKEWLNKVG
360 370 380 390 400
WFDEEFNHWG GEDVEFGYRL FAKGCFFRVI DGGMAYHQEP PGKENETDRE
410 420 430 440 450
AGKSITLKIV KEKVPYIYRK LLPIEDSHIH RIPLVSIYIP AYNCANYIQR
460 470 480 490 500
CVDSALNQTV VDLEVCICND GSTDNTLEVI NKLYGNNPRV RIMSKPNGGI
510 520 530 540 550
ASASNAAVSF AKGYYIGQLD SDDYLEPDAV ELCLKEFLKD KTLACVYTTN
560 570 580 590 600
RNVNPDGSLI ANGYNWPEFS REKLTTAMIA HHFRMFTIRA WHLTDGFNEK
610 620 630 640 650
IENAVDYDMF LKLSEVGKFK HLNKICYNRV LHGDNTSIKN LDTQKKNHFV
660 670 680 690 700
VVNQSLNRQR VSNYNYDEFD NLDESRKYIF NKTADYQEEI DILKDIKIVQ
710 720 730 740 750
RKDAKVAISI FYPNRLDGLV KKLNNIIEYN KNVLIIVLHI DKNHLTSDIK
760 770 780 790 800
KEILEFHNKN QINILLNNDV SYYTNNRLIK TKAHLSNMNK LRQLNLNLEY
810 820 830 840 850
IIFDNHDSLF IKNDSYNHIK KYDIGMNFSS LTNDWINKIN AHSPFKNLIK
860 870 880 890 900
KYFNDNDLKT INMKGASQGM FIKYTLAHDI ATIMKEVITL CQSTDSVPEY
910 920 930 940 950
NTEDIWFQFA LLILEKKTGH VFNKTSTLTY MPWERKLQWT NEQIESAKRG
960
ENIPVNKFII NSITL
Length:965
Mass (Da):111,601
Last modified:June 1, 2001 - v1
Checksum:i9C4B2CF80E1A6BD7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti157I → T in AAK17921 (PubMed:11230405).Curated1
Sequence conflicti170L → S in AAK17921 (PubMed:11230405).Curated1
Sequence conflicti600K → N in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti640 – 643NLDT → KLGI in AAF97500 (PubMed:10818104).Curated4
Sequence conflicti660 – 663RVSN → GINY in AAF97500 (PubMed:10818104).Curated4
Sequence conflicti668E → K in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti671N → D in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti685D → E in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti690I → M in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti696 – 701IKIVQR → LKLIQN in AAF97500 (PubMed:10818104).Curated6
Sequence conflicti706 – 708VAI → IAV in AAF97500 (PubMed:10818104).Curated3
Sequence conflicti715 – 717RLD → TLN in AAF97500 (PubMed:10818104).Curated3
Sequence conflicti733 – 740VLIIVLHI → IFVIILHV in AAF97500 (PubMed:10818104).Curated8
Sequence conflicti747S → P in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti755 – 762EFHNKNQI → AFYHKHQV in AAF97500 (PubMed:10818104).Curated8
Sequence conflicti770V → I in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti775N → S in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti782K → E in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti788M → I in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti792R → S in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti798L → C in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti811I → V in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti817 – 819NHI → AYM in AAF97500 (PubMed:10818104).Curated3
Sequence conflicti824I → V in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti830S → A in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti833N → H in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti837N → E in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti843S → P in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti847N → K in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti851K → T in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti859 – 863KTINM → RSMNV in AAF97500 (PubMed:10818104).Curated5
Sequence conflicti872I → M in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti875 – 884TLAHDIATIM → ALPHELLTII in AAF97500 (PubMed:10818104).Curated10
Sequence conflicti890L → S in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti894T → I in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti910A → V in AAT10183 (Ref. 4) Curated1
Sequence conflicti945E → Q in AAF97500 (PubMed:10818104).Curated1
Sequence conflicti949R → K in AAF97500 (PubMed:10818104).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195517 Genomic DNA. Translation: AAF97500.2.
AF302467 Genomic DNA. Translation: AAK17921.1.
AY604234 Genomic DNA. Translation: AAT10183.1.
AE004439 Genomic DNA. Translation: AAK02859.1.
RefSeqiWP_010906847.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK02859; AAK02859; PM0775.
GeneIDi1244122.
KEGGipmu:PM0775.
PATRICi22870748. VBIPasMul88067_0784.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF195517 Genomic DNA. Translation: AAF97500.2.
AF302467 Genomic DNA. Translation: AAK17921.1.
AY604234 Genomic DNA. Translation: AAT10183.1.
AE004439 Genomic DNA. Translation: AAK02859.1.
RefSeqiWP_010906847.1. NC_002663.1.

3D structure databases

ProteinModelPortaliQ9CMP0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272843.PM0775.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK02859; AAK02859; PM0775.
GeneIDi1244122.
KEGGipmu:PM0775.
PATRICi22870748. VBIPasMul88067_0784.

Phylogenomic databases

eggNOGiCOG0726. LUCA.
HOGENOMiHOG000154388.
KOiK13500.
OMAiEVCICND.

Enzyme and pathway databases

BRENDAi2.4.1.175. 4558.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR001173. Glyco_trans_2-like.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PfamiPF00535. Glycos_transf_2. 2 hits.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiCHS_PASMU
AccessioniPrimary (citable) accession number: Q9CMP0
Secondary accession number(s): Q6PKM8, Q9AHL6, Q9KJ99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.