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Protein

Lipid A export ATP-binding/permease protein MsbA

Gene

msbA

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi376 – 383ATPUniRule annotation8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
Biological processLipid transport, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid A export ATP-binding/permease protein MsbAUniRule annotation (EC:3.6.3.-UniRule annotation)
Gene namesi
Name:msbAUniRule annotation
Ordered Locus Names:PM0861
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

Subcellular locationi

Q9CMG7:
  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 88HelicalUniRule annotationAdd BLAST21
Transmembranei140 – 160HelicalUniRule annotationAdd BLAST21
Transmembranei161 – 181HelicalUniRule annotationAdd BLAST21
Transmembranei254 – 274HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000925911 – 582Lipid A export ATP-binding/permease protein MsbAAdd BLAST582

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272843.PM0861.

Structurei

3D structure databases

ProteinModelPortaliQ9CMG7.
SMRiQ9CMG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 310ABC transmembrane type-1UniRule annotationAdd BLAST285
Domaini342 – 578ABC transporterUniRule annotationAdd BLAST237

Domaini

In MsbA the ATP-binding domain (NBD) and the transmembrane domain (TMD) are fused.

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105BZ1. Bacteria.
COG1132. LUCA.
KOiK11085.
OMAiSPLMEFL.

Family and domain databases

Gene3Di1.20.1560.10. 1 hit.
InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR036640. ABC1_TM_sf.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR011917. ABC_transpr_lipidA.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
TIGRFAMsiTIGR02203. MsbA_lipidA. 1 hit.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51239. MSBA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CMG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQDKDLSTVQ TFKRLWPIIS PFKLGLVVSG IALVINALAD AGLISLLKPL
60 70 80 90 100
LDEGFGKADV SFLRTMSYVV VLVIFLRGIS NFISSYCLSW VSGKVVMIMR
110 120 130 140 150
RRIFKHLMFM PVPFFDQNSS GRLLSRITYD SELVANSSSG ALITIVREGA
160 170 180 190 200
YIISLLAVML YTSWQLSIVL FLIGPIIAVL IRFVSKRFRE LSKNMQNSMG
210 220 230 240 250
ELTSTAEQML KGHKVVLSFG GQIVEEERFN HVSNDMRRKG MKMAVADAIS
260 270 280 290 300
NPVVQIIASF ALAAVLYLAT VPTIMDQNLT AGSFTVVFSS MLAMMRPLKS
310 320 330 340 350
LTNVNAQFQK GMAACQTLFA LLDLETEKDL GTHKGENVQG YLSFKNVTFT
360 370 380 390 400
YQSRDEPALR NLSFDVEKGK TVALVGRSGS GKSTIANLVT RFYDVDQGEI
410 420 430 440 450
TLDGINIQDY RLSSLRKNCA VVSQQVHLFN DTIANNIAYA AKDKYSREEI
460 470 480 490 500
IKAAKDAYAM EFIEKLEHGL DTVIGENGVN LSGGQRQRLA IARALLRNSP
510 520 530 540 550
VLILDEATSA LDTESERSIQ LALEKLQKER TVIVIAHRLS TIENADEILV
560 570 580
IEHGEIKERG SHSELLALNG AYKQLHHIQV NH
Length:582
Mass (Da):64,565
Last modified:June 1, 2001 - v1
Checksum:iB798BFAE4673C881
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK02945.1.
RefSeqiWP_005716843.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK02945; AAK02945; PM0861.
KEGGipmu:PM0861.
PATRICifig|272843.6.peg.871.

Similar proteinsi

Entry informationi

Entry nameiMSBA_PASMU
AccessioniPrimary (citable) accession number: Q9CMG7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families