Q9CMF9 (Q9CMF9_PASMU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Acetolactate synthase RuleBase RU003591
EC=2.2.1.6 RuleBase RU003591

Gene names

Name:	ilvI EMBL AAK02954.1
Ordered Locus Names:	PM0870

Organism

Pasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]

Taxonomic identifier

272843 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	574 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2 pyruvate = 2-acetolactate + CO2. RuleBase RU003591
Cofactor	Binds 1 magnesium ion per subunit By similarity. RuleBase RU003591 Binds 1 thiamine pyrophosphate per subunit By similarity. RuleBase RU003591
Pathway	Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 1/4. RuleBase RU003591 Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 1/4. RuleBase RU003591
Sequence similarities	Belongs to the TPP enzyme family. RuleBase RU003702

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis RuleBase RU003591
Ligand	Magnesium RuleBase RU003591 Metal-binding RuleBase RU003591 Thiamine pyrophosphate RuleBase RU003591
Molecular function	Transferase RuleBase RU003591
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	branched chain family amino acid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	acetolactate synthase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro thiamine pyrophosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9CMF9 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 6429FBC2227E36BF	FASTA	574	62,726
	10 20 30 40 50 60 MKKLSGAEMV VQSLRDEGVE FLFGYPGGSV LDIYDAIHTL GGIEHILVRH EQAAVHMADG 70 80 90 100 110 120 YARATGKVGC VLVTSGPGAT NTITGIATAY MDSVPLIILS GQVMSGLIGS DAFQECDMVG 130 140 150 160 170 180 ISRPVVKHSF LVKSAAEIPE TIKKAFYIAS TGRPGPVVID LPKDVVNPAH KFTYHYPERV 190 200 210 220 230 240 ELRSYNPTIQ GHKGQIKKAL KALLVAKKPV LFVGGGVITA NCSDKLTQFA QTLNLPVTSS 250 260 270 280 290 300 LMGLGAYPSS DKQFLGMLGM HGTYEANNAM HHSDLILGIG VRFDDRTTNN LAKYCPHAKV 310 320 330 340 350 360 IHIDIDPTSI SKNVLASIPI VGSAEKVINE FLALLEDDNL LKSQTALDEW WQQIDEWKAV 370 380 390 400 410 420 KCLSFTRDDS VIKPQQVMEV VYRLTQGEAY VASDVGQHQM FAALHYPFNQ PRRWINSGGL 430 440 450 460 470 480 GTMGFGLPAA LGVKLAYPDS TVVCVTGDGS IQMNIQELST AQQYDIPIVI ISLNNRFLGM 490 500 510 520 530 540 VKQWQDLIYS GRHSQSYMNS LPDFVKLAEA YGHVGIQINT PDELEEKLTQ AFSMKDKLVF 550 560 570 VDINVDATEH VYPMQVRGGA MNEMILTKPE KANA

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004439 Genomic DNA. Translation: AAK02954.1.
RefSeq	NP_245807.1. NC_002663.1.
3D structure databases
HSSP	HSSP built from PDB template 1N0H based on UniProtKB P07342.
ProteinModelPortal	Q9CMF9.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1244217.
GenomeReviews	Gene locus PM0870 in contig AE004439_GR.
KEGG	pmu:PM0870.
NMPDR	fig|272843.1.peg.870.
PATRIC	22870944. VBIPasMul88067_0880.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG323037.
OMA	RMNINEL.
ProtClustDB	PRK06882.
Enzyme and pathway databases
BioCyc	PMUL272843:PM0870-MONOMER.
Family and domain databases
InterPro	IPR012846. Acetolactate_synth_lsu. IPR012000. Thiamin_PyroP_enz_cen_dom. IPR012001. Thiamin_PyroP_enz_TPP-bd_dom. IPR000399. TPP-bd_CS. IPR011766. TPP_enzyme-bd_C. [Graphical view]
KO	K01652.
PANTHER	PTHR18968:SF13. PTHR18968:SF13. 1 hit.
Pfam	PF02775. TPP_enzyme_C. 1 hit. PF00205. TPP_enzyme_M. 1 hit. PF02776. TPP_enzyme_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00118. Acolac_lg. 1 hit.
PROSITE	PS00187. TPP_ENZYMES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9CMF9_PASMU

Accession

Primary (citable) accession number: Q9CMF9

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	December 14, 2011
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)