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Protein

Formyltetrahydrofolate deformylase

Gene

purU

Organism
Pasteurella multocida (strain Pm70)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4).UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate.UniRule annotation

Pathwayi: IMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Formyltetrahydrofolate deformylase (purU)
This subpathway is part of the pathway IMP biosynthesis via de novo pathway, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes formate from 10-formyl-5,6,7,8-tetrahydrofolate, the pathway IMP biosynthesis via de novo pathway and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei223UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotation
Biological processOne-carbon metabolismUniRule annotation, Purine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00074; UER00170.

Names & Taxonomyi

Protein namesi
Recommended name:
Formyltetrahydrofolate deformylaseUniRule annotation (EC:3.5.1.10UniRule annotation)
Alternative name(s):
Formyl-FH(4) hydrolaseUniRule annotation
Gene namesi
Name:purUUniRule annotationImported
Ordered Locus Names:PM0873Imported
OrganismiPasteurella multocida (strain Pm70)Imported
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272843.PM0873.

Structurei

3D structure databases

ProteinModelPortaliQ9CMF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 85ACTInterPro annotationAdd BLAST80

Sequence similaritiesi

Belongs to the PurU family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CIY. Bacteria.
COG0788. LUCA.
HOGENOMiHOG000033576.
KOiK01433.
OMAiHADHHTD.

Family and domain databases

Gene3Di3.40.50.170. 1 hit.
HAMAPiMF_01927. PurU. 1 hit.
InterProiView protein in InterPro
IPR002912. ACT_dom.
IPR002376. Formyl_transf_N.
IPR036477. Formyl_transf_N_sf.
IPR004810. PurU.
PANTHERiPTHR42706. PTHR42706. 1 hit.
PfamiView protein in Pfam
PF01842. ACT. 1 hit.
PF00551. Formyl_trans_N. 1 hit.
PRINTSiPR01575. FFH4HYDRLASE.
SUPFAMiSSF53328. SSF53328. 1 hit.
TIGRFAMsiTIGR00655. PurU. 1 hit.
PROSITEiView protein in PROSITE
PS51671. ACT. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CMF6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIENKILLTD CPDDKGLIAK ITNICYKHQL NIIHNNEFVD FDTKHFFMRT
60 70 80 90 100
ELQGIFNEDT LLADLKFSLP EGTNCRLISA KRKRIVILVT KEAHCLGDIL
110 120 130 140 150
MKNYYGGLDV EIAAVIGNHD TLRTLVERFD IPFHYISHHD LTRVEHDKLL
160 170 180 190 200
ADKIDEYTPD YIVLAKYMRV LNPQFVEKYP NRVINIHHSF LPAFIGAKPY
210 220 230 240 250
HQAYERGVKI IGATAHFINN ELDQGPIIMQ NVINVDHTYN AEAMMRAGRD
260 270
VEKTVLSRAL DLALHDRIFV YKNKTVVL
Length:278
Mass (Da):32,086
Last modified:June 1, 2001 - v1
Checksum:iF303E499DFFA0B70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK02957.1.
RefSeqiWP_005722683.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK02957; AAK02957; PM0873.
KEGGipmu:PM0873.
PATRICifig|272843.6.peg.884.

Similar proteinsi

Entry informationi

Entry nameiQ9CMF6_PASMU
AccessioniPrimary (citable) accession number: Q9CMF6
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 90 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported