Q9CMB1 (MSRB_PASMU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Ordered Locus Names:	PM0923

Organism

Pasteurella multocida (strain Pm70) [Complete proteome] [HAMAP]

Taxonomic identifier

272843 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Cofactor	Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein By similarity.
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Ligand	Metal-binding Zinc
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 130	130	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_0000140285
Sites
	Active site	111	1	Nucleophile By similarity
	Metal binding	39	1	Zinc By similarity
	Metal binding	42	1	Zinc By similarity
	Metal binding	88	1	Zinc By similarity
	Metal binding	91	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CMB1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: CC5975080A564A95	FASTA	130	14,675
	10 20 30 40 50 60 MKKREDMTEM QVHVCLNQGT EYPFTGKLLD QQKKGLYRCV VCHSPLFVSD TKFDAGCGWP 70 80 90 100 110 120 SFFQAISPEA IRYLDDYTLS RPRTEIRCGQ CDAHLGHVFE DGPPPTGLRY CVNSVSMAFE 130 DSETGELIEG

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004439 Genomic DNA. Translation: AAK03007.1.
RefSeq	NP_245860.1. NC_002663.1.
3D structure databases
ProteinModelPortal	Q9CMB1.
SMR	Q9CMB1. Positions 4-121.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1244270.
GenomeReviews	Gene locus PM0923 in contig AE004439_GR.
KEGG	pmu:PM0923.
NMPDR	fig|272843.1.peg.923.
PATRIC	22871063. VBIPasMul88067_0933.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG715255.
OMA	LFESATK.
ProtClustDB	PRK00222.
Enzyme and pathway databases
BioCyc	PMUL272843:PM0923-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_PASMU

Accession

Primary (citable) accession number: Q9CMB1

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program