Reviewed, UniProtKB/Swiss-Prot Q9CLY7 (MTLD_PASMU)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	PM1062

Organism

Pasteurella multocida [Complete proteome] [HAMAP]

Taxonomic identifier

747 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Pasteurella

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170715
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CLY7-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: ABEB7345ABB52DE2	FASTA	385	42,595
	10 20 30 40 50 60 MKALHFGAGN IGRGFIGKLL ADSGIQVIFA DVNDHVIEQL KTQRAYPVKI VGDRLNVIET 70 80 90 100 110 120 VSNVTGVNSK NEADIIACFT EVDLVTTAVG PNVLKIISST IAKGLSARFR AGNTRPLNII 130 140 150 160 170 180 ACENMVRGTS FLKDNVFSYL TPEEQQQAEA QIGFVDSAVD RIVPPVQFDP ANPLLVTVEE 190 200 210 220 230 240 FSEWIVDKTQ FKGTIPAITG MEQTDNLMAF VERKLFTLNT GHATTAYLGK LKGHQFVKDS 250 260 270 280 290 300 IDDPDIREAV KATMQESGAV LIKRYGFDPH AHAAYIEKIL KRFANPYLQD DVDRVGREPL 310 320 330 340 350 360 RKLSYNDRLI KPLRGTLEYG LPNQHLIQTI ASALAYRNES DPQAVELAQL LQQDTLESAV 370 380 KKITELTESN IVQQIVTAYN ALQKN

References

[1]	"Complete genomic sequence of Pasteurella multocida Pm70." May B.J., Zhang Q., Li L.L., Paustian M.L., Whittam T.S., Kapur V. Proc. Natl. Acad. Sci. U.S.A. 98:3460-3465(2001) [PubMed: 11248100] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Pm70.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE004439 Genomic DNA. Translation: AAK03146.1.
RefSeq	NP_245999.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1244409.
GenomeReviews	Gene locus PM1062 in contig AE004439_GR.
KEGG	pmu:PM1062.
NMPDR	fig|272843.1.peg.1062.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG568825.
OMA	VDRIVPN.
Enzyme and pathway databases
BRENDA	1.1.1.17. 258935.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_PASMU

Accession

Primary (citable) accession number: Q9CLY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	June 1, 2001
Last modified:	January 19, 2010
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)