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Q9CLU1

- PNP_PASMU

UniProt

Q9CLU1 - PNP_PASMU

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Protein
Polyribonucleotide nucleotidyltransferase
Gene
pnp, PM1114
Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi488 – 4881Magnesium By similarity
Metal bindingi494 – 4941Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. RNA binding Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. RNA processing Source: InterPro
  2. mRNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-1159-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:PM1114
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Polyribonucleotide nucleotidyltransferaseUniRule annotation
PRO_0000329750Add
BLAST

Proteomic databases

PRIDEiQ9CLU1.

Interactioni

Subunit structurei

Component of the RNA degradosome, which is a multiprotein complex involved in RNA processing and mRNA degradation By similarity.

Protein-protein interaction databases

STRINGi272843.PM1114.

Structurei

3D structure databases

ProteinModelPortaliQ9CLU1.
SMRiQ9CLU1. Positions 619-693.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 61460KH
Add
BLAST
Domaini624 – 69269S1 motif
Add
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view]
PIRSFiPIRSF005499. PNPase. 1 hit.
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CLU1-1 [UniParc]FASTAAdd to Basket

« Hide

MNPIVKQFKY GQHTVTLETG AIARQATAAV MASMDDTTVF VTVVAKKDVK    50
EGQDFFPLTV NYQERTYAAG RIPGGFFKRE GRPSEGETLI ARLIDRPIRP 100
LFPEGFYNEI QIVATVVSVN PQICPDLVAM IGASAALSLS GVPFNGPIGA 150
ARVGFIDDQF VLNPTMNEQK QSRLDLVVAG TDKAVLMVES EADVLTEEQM 200
LAAVVFGHQQ QQVVIDAIKE FTAEAGKPRW DWVAPEPNTA LIEKVKAIAE 250
ARLGEAYRIT EKQARYEQID AIKADVIAQI TAEVAEGEDI SEGKIVDIFT 300
ALESQIVRSR IIAGEPRIDG RTVDTVRALD ICTGVLPRTH GSAIFTRGET 350
QALAVATLGT ERDAQIIDEL TGERSDHFLF HYNFPPYSVG ETGMIGSPKR 400
REIGHGRLAK RGVAAVMPTL AEFPYVVRVV SEITESNGSS SMASVCGASL 450
ALMDAGVPIK AAVAGIAMGL VKEDEKFVVL SDILGDEDHL GDMDFKVAGT 500
RTGVTALQMD IKIEGITAEI MQIALNQAKS ARLHILGVME QAIPAPRADI 550
SDFAPRIYTM KIDPKKIKDV IGKGGATIRA LTEETGTSID IDDDGTVKIA 600
AVDGNSAKEV MARIEDITAE VEAGAVYKGK VTRLADFGAF VSIVGNKEGL 650
VHISQIAEER VEKVSDYLAV GQEVTVKVVE IDRQGRIRLT MKEVAPKQEH 700
VDSVVADVAA EENA 714
Length:714
Mass (Da):77,011
Last modified:June 1, 2001 - v1
Checksum:iDB4E3096C9BB1A65
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK03198.1.
AF237935 Genomic DNA. Translation: AAF68421.1.
RefSeqiNP_246051.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK03198; AAK03198; PM1114.
GeneIDi1244461.
KEGGipmu:PM1114.
PATRICi22871475. VBIPasMul88067_1127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK03198.1 .
AF237935 Genomic DNA. Translation: AAF68421.1 .
RefSeqi NP_246051.1. NC_002663.1.

3D structure databases

ProteinModelPortali Q9CLU1.
SMRi Q9CLU1. Positions 619-693.
ModBasei Search...

Protein-protein interaction databases

STRINGi 272843.PM1114.

Proteomic databases

PRIDEi Q9CLU1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK03198 ; AAK03198 ; PM1114 .
GeneIDi 1244461.
KEGGi pmu:PM1114.
PATRICi 22871475. VBIPasMul88067_1127.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci PMUL272843:GC8W-1159-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 2 hits.
PF00575. S1. 1 hit.
[Graphical view ]
PIRSFi PIRSF005499. PNPase. 1 hit.
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.
  2. "Identification of Pasteurella multocida virulence genes in a septicemic mouse model using signature-tagged mutagenesis."
    Fuller T.E., Kennedy M.J., Lowery D.E.
    Microb. Pathog. 29:25-38(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-714.

Entry informationi

Entry nameiPNP_PASMU
AccessioniPrimary (citable) accession number: Q9CLU1
Secondary accession number(s): Q9L6A4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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