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Protein

Magnesium transport protein CorA

Gene

corA

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Mediates influx of magnesium ions. Can also mediate cobalt and manganese uptake (By similarity). Alternates between open and closed states. Activated by low cytoplasmic Mg2+ levels. Inactive when cytoplasmic Mg2+ levels are high (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei253Essential for ion permeationBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Magnesium transport protein CorA
Gene namesi
Name:corA
Ordered Locus Names:PM1315
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002390991 – 316Magnesium transport protein CorAAdd BLAST316

Interactioni

Subunit structurei

Homopentamer. In the absence of Mg2+, interactions between subunits are weakened, and dimers, trimers and tetramers can be observed in vitro (By similarity).By similarity

Protein-protein interaction databases

STRINGi272843.PM1315.

Structurei

3D structure databases

ProteinModelPortaliQ9CLC4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi277 – 279Probable selectivity filterBy similarity3

Domaini

The central ion permeation pathway is formed by the first transmembrane domain from each of the five subunits. Mg2+ binding strengthens interactions between subunits and leads to the formation of a symmetrical homopentamer surrounding a closed ion permeation pathway. Co2+ binding also induces a conformation change. Low Mg2+ concentrations trigger both a conformation change within each subunit and a loosening of the interactions between subunits. This results in an open ion conduction pathway. In addition, this results in a less symmetrical shape of the whole complex.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107QUT. Bacteria.
COG0598. LUCA.
HOGENOMiHOG000276873.
KOiK03284.
OMAiRRAVSFM.

Family and domain databases

InterProiIPR004488. Mg/Co-transport_prot_CorA.
IPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
[Graphical view]
PfamiPF01544. CorA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00383. corA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CLC4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINAFALEDA RLVRIDENTN AELNSAIWLD LIEPSSEERE ILQEGLGQSL
60 70 80 90 100
ATFLELEDIE ASARFFEDED GLHLHSFFYC EDEEDYADLA SVAFTVRDGR
110 120 130 140 150
LFTLRDRELP AFRLYRMRSR SQRLIECNAY EVLLDLFETK IEQLADVIET
160 170 180 190 200
VYSDLEKLSR VILDGTQGEA FDQALSTLTE QEDTSSKVRL CLMDTQRALS
210 220 230 240 250
FLVRKTRLPA NQLEQAREIL RDIESLQPHN ESLFQRVNFL MQAAMGFISI
260 270 280 290 300
EQNRIIKIFS VVSVIFLPPT LVASNYGMNF DIMPELGFKF GYPMALGLMA
310
LAAFAPYWYF KRKGWL
Length:316
Mass (Da):36,423
Last modified:June 1, 2001 - v1
Checksum:iAD3EF4C4BC0ACC99
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK03399.1.
RefSeqiWP_005717802.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK03399; AAK03399; PM1315.
GeneIDi1244662.
KEGGipmu:PM1315.
PATRICi22871883. VBIPasMul88067_1326.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK03399.1.
RefSeqiWP_005717802.1. NC_002663.1.

3D structure databases

ProteinModelPortaliQ9CLC4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272843.PM1315.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK03399; AAK03399; PM1315.
GeneIDi1244662.
KEGGipmu:PM1315.
PATRICi22871883. VBIPasMul88067_1326.

Phylogenomic databases

eggNOGiENOG4107QUT. Bacteria.
COG0598. LUCA.
HOGENOMiHOG000276873.
KOiK03284.
OMAiRRAVSFM.

Family and domain databases

InterProiIPR004488. Mg/Co-transport_prot_CorA.
IPR002523. MgTranspt_CorA/ZnTranspt_ZntB.
[Graphical view]
PfamiPF01544. CorA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00383. corA. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCORA_PASMU
AccessioniPrimary (citable) accession number: Q9CLC4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.