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Q9CLC2

- TRMB_PASMU

UniProt

Q9CLC2 - TRMB_PASMU

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Protein
tRNA (guanine-N(7)-)-methyltransferase
Gene
trmB, PM1317
Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(46) in tRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(46) in tRNA.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861S-adenosyl-L-methionine By similarity
Binding sitei111 – 1111S-adenosyl-L-methionine By similarity
Binding sitei138 – 1381S-adenosyl-L-methionine By similarity
Active sitei161 – 1611 By similarity
Binding sitei161 – 1611S-adenosyl-L-methionine By similarity
Binding sitei165 – 1651Substrate By similarity
Binding sitei197 – 1971Substrate By similarity

GO - Molecular functioni

  1. tRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-1368-MONOMER.
UniPathwayiUPA00989.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.33)
Alternative name(s):
tRNA (guanine(46)-N(7))-methyltransferase
tRNA(m7G46)-methyltransferase
Gene namesi
Name:trmB
Ordered Locus Names:PM1317
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 255255tRNA (guanine-N(7)-)-methyltransferaseUniRule annotation
PRO_0000171368Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272843.PM1317.

Structurei

3D structure databases

ProteinModelPortaliQ9CLC2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni234 – 2374Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0220.
HOGENOMiHOG000073968.
KOiK03439.
OMAiHSTLEMA.
OrthoDBiEOG6K6VBC.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_01057. tRNA_methyltr_TrmB.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view]
PfamiPF02390. Methyltransf_4. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00091. TIGR00091. 1 hit.
PROSITEiPS51625. SAM_MT_TRMB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CLC2-1 [UniParc]FASTAAdd to Basket

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MSFNNQESEN LPTFADQKRK TVEVAEFTAE GRYKRKVRSF VLRTGRLSEF    50
QKNAMNQHWG FYGLEHQNQP FDFPAIYGNN NPVVLEIGFG MGHSLVDMAL 100
QNPERNYLGI EVHTPGVGAC IAYAVEKGVK NLRIICHDAT EILRDCIADH 150
SLGGLQLFFP DPWHKAKHHK RRIVQPQFVN TITQKLTTGG FIHMATDWEN 200
YAEHMLAVLQ QAEGLQNTSA THDYIPRPDF RPLTKFEQRG HRLGHGVWDL 250
YYIKK 255
Length:255
Mass (Da):29,319
Last modified:June 1, 2001 - v1
Checksum:iD3F07ADF145D2980
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK03401.1.
RefSeqiNP_246255.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK03401; AAK03401; PM1317.
GeneIDi1244664.
KEGGipmu:PM1317.
PATRICi22871887. VBIPasMul88067_1328.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK03401.1 .
RefSeqi NP_246255.1. NC_002663.1.

3D structure databases

ProteinModelPortali Q9CLC2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272843.PM1317.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK03401 ; AAK03401 ; PM1317 .
GeneIDi 1244664.
KEGGi pmu:PM1317.
PATRICi 22871887. VBIPasMul88067_1328.

Phylogenomic databases

eggNOGi COG0220.
HOGENOMi HOG000073968.
KOi K03439.
OMAi HSTLEMA.
OrthoDBi EOG6K6VBC.

Enzyme and pathway databases

UniPathwayi UPA00989 .
BioCyci PMUL272843:GC8W-1368-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_01057. tRNA_methyltr_TrmB.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR003358. tRNA_(Gua-N-7)_MeTrfase.
[Graphical view ]
Pfami PF02390. Methyltransf_4. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00091. TIGR00091. 1 hit.
PROSITEi PS51625. SAM_MT_TRMB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.

Entry informationi

Entry nameiTRMB_PASMU
AccessioniPrimary (citable) accession number: Q9CLC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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