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Q9CL60

- SPEA_PASMU

UniProt

Q9CL60 - SPEA_PASMU

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Protein

Biosynthetic arginine decarboxylase

Gene
speA, PM1382
Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-1435-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:PM1382
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 644644Biosynthetic arginine decarboxylaseUniRule annotationPRO_0000149966Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei113 – 1131N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi272843.PM1382.

Structurei

3D structure databases

ProteinModelPortaliQ9CL60.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni293 – 30311Substrate-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
HOGENOMiHOG000029191.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.
PROSITEiPS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CL60-1 [UniParc]FASTAAdd to Basket

« Hide

MEQVTLTSDG TSSVFAENTV REVCNINYWG MRYYNVDEKG DIFVCPDPDK    50
PQNRVSLAAL AEKVQREQGA HLPTLFCFPQ IIQHRLRSIN QAFKRAREDF 100
GYEGNYFLVY PIKVNQHRRI VESLISSGQP LGLEAGSKAE LMAVLAHAGI 150
TQTVIVCNGY KDREYVRFAL MGEKLGHKVY LVIEKLSEIQ LVLEEAAKLN 200
VKPRLGVRAR LASQGSGKWQ SSGGEKSKFG LSASQVLSLV QMLKEHECLD 250
CLQLLHFHLG SQLGNIRDVA TGVRESARFY VELHKLGVNI QCFDVGGGLG 300
VDYEGNRTQS DCSVNYGLNE YADTVVWGIG QACREHGLPH PTIITESGRG 350
VTAHHAVLVS NVIGVERYKF ETLAAPAKDA PSVLHSMWET WVDIQSSREK 400
RSLRSWIHES QFDLSDVHNQ YNVGLLNLEQ RAWAEQLYLN ICHEVGQLFN 450
EKHRSHRTII DELQERFADK LYVNFSLFQS LPDAWGIDQL FPVCPISNLN 500
QPVSRRAVLL DITCDSDGTI DHYIDGDGIT TTMPMPHYEE DNPPLLGFFM 550
VGAYQEILGN MHNLFGDTST VDVLVHEQDK AYIVDYDEGN TVADMLEYVY 600
LDPKKLLDRY REQIEHSNLP ASEAIQFLNE LEVGLNGYTY LEDE 644
Length:644
Mass (Da):72,707
Last modified:June 1, 2001 - v1
Checksum:iF6A7FEB0B8DE3D82
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK03466.1.
RefSeqiNP_246321.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK03466; AAK03466; PM1382.
GeneIDi1244729.
KEGGipmu:PM1382.
PATRICi22872023. VBIPasMul88067_1394.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK03466.1 .
RefSeqi NP_246321.1. NC_002663.1.

3D structure databases

ProteinModelPortali Q9CL60.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272843.PM1382.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK03466 ; AAK03466 ; PM1382 .
GeneIDi 1244729.
KEGGi pmu:PM1382.
PATRICi 22872023. VBIPasMul88067_1394.

Phylogenomic databases

eggNOGi COG1166.
HOGENOMi HOG000029191.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.

Enzyme and pathway databases

BioCyci PMUL272843:GC8W-1435-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022657. De-COase2_CS.
IPR022644. De-COase2_N.
IPR022653. De-COase2_pyr-phos_BS.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
PROSITEi PS00878. ODR_DC_2_1. 1 hit.
PS00879. ODR_DC_2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.

Entry informationi

Entry nameiSPEA_PASMU
AccessioniPrimary (citable) accession number: Q9CL60
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: June 1, 2001
Last modified: June 11, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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