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Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

Pathwayi: LPS lipid A biosynthesis

This protein is involved in the pathway LPS lipid A biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway LPS lipid A biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00973

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:lpxDUniRule annotation
Synonyms:firA
Ordered Locus Names:PM1994
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000596861 – 342UDP-3-O-acylglucosamine N-acyltransferaseAdd BLAST342

Proteomic databases

PRIDEiQ9CJL0

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi272843.PM1994

Structurei

3D structure databases

ProteinModelPortaliQ9CJL0
SMRiQ9CJL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105D7M Bacteria
COG1044 LUCA
HOGENOMiHOG000294339
KOiK02536
OMAiGFGYAHT

Family and domain databases

CDDicd03352 LbH_LpxD, 1 hit
HAMAPiMF_00523 LpxD, 1 hit
InterProiView protein in InterPro
IPR001451 Hexapep
IPR018357 Hexapep_transf_CS
IPR007691 LpxD
IPR011004 Trimer_LpxA-like_sf
IPR020573 UDP_GlcNAc_AcTrfase_non-rep
PANTHERiPTHR43378 PTHR43378, 1 hit
PfamiView protein in Pfam
PF00132 Hexapep, 3 hits
PF04613 LpxD, 1 hit
SUPFAMiSSF51161 SSF51161, 1 hit
TIGRFAMsiTIGR01853 lipid_A_lpxD, 1 hit
PROSITEiView protein in PROSITE
PS00101 HEXAPEP_TRANSFERASES, 3 hits

Sequencei

Sequence statusi: Complete.

Q9CJL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVYSLQELA QQIGATIRGN ADVVVESIAP LDKATEKQLT FISNPKFRSL
60 70 80 90 100
LAQSHAGILV VSEADVAFCA EQSNLLIVKD PYVAYAVLAQ YMDSTPKAAS
110 120 130 140 150
GIAASAVVSA SAVIGKNVSI GANAVIEDGV TLGDHVVIGA NCFVGKNSKI
160 170 180 190 200
GAYTQLWANV SVYHEVEIGQ HCLIQSGAVI GSDGFGYAND RGRWIKIPQV
210 220 230 240 250
GQVIIGNHVE IGACTCIDRG ALDPTVIEDN VIIDNLCQIA HNVHIGTGTA
260 270 280 290 300
VAGGVIMAGS LTVGRYCLIG GASVINGHME ICDKVTITGM GMVMRPITEP
310 320 330 340
GVYSSGIPLQ TNKEWRKTAA LTLGIDAMNK RLKALEKKFE KK
Length:342
Mass (Da):36,049
Last modified:June 1, 2001 - v1
Checksum:i117A01B0A04342D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA Translation: AAK04078.1
X74357 Genomic DNA Translation: CAA52401.1
PIRiS47342
RefSeqiWP_005725095.1, NC_002663.1

Genome annotation databases

EnsemblBacteriaiAAK04078; AAK04078; PM1994
GeneIDi29388993
KEGGipmu:PM1994

Similar proteinsi

Entry informationi

Entry nameiLPXD_PASMU
AccessioniPrimary (citable) accession number: Q9CJL0
Secondary accession number(s): Q51923
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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