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Protein

UDP-3-O-acylglucosamine N-acyltransferase

Gene

lpxD

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + UDP-3-O-acyl-alpha-D-glucosamine = UDP-2,3-diacyl-alpha-D-glucosamine + [acyl-carrier-protein].UniRule annotation

Pathwayi: LPS lipid A biosynthesis

This protein is involved in the pathway LPS lipid A biosynthesis, which is part of Bacterial outer membrane biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway LPS lipid A biosynthesis and in Bacterial outer membrane biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei241Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00973.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-3-O-acylglucosamine N-acyltransferaseUniRule annotation (EC:2.3.1.-UniRule annotation)
Gene namesi
Name:lpxDUniRule annotation
Synonyms:firA
Ordered Locus Names:PM1994
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
Proteomesi
  • UP000000809 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000596861 – 342UDP-3-O-acylglucosamine N-acyltransferaseAdd BLAST342

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi272843.PM1994.

Structurei

3D structure databases

ProteinModelPortaliQ9CJL0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family. LpxD subfamily.UniRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG4105D7M. Bacteria.
COG1044. LUCA.
HOGENOMiHOG000294339.
KOiK02536.
OMAiSYPAKIM.

Family and domain databases

CDDicd03352. LbH_LpxD. 1 hit.
HAMAPiMF_00523. LpxD. 1 hit.
InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR007691. LpxD.
IPR011004. Trimer_LpxA-like.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamiPF00132. Hexapep. 3 hits.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CJL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVYSLQELA QQIGATIRGN ADVVVESIAP LDKATEKQLT FISNPKFRSL
60 70 80 90 100
LAQSHAGILV VSEADVAFCA EQSNLLIVKD PYVAYAVLAQ YMDSTPKAAS
110 120 130 140 150
GIAASAVVSA SAVIGKNVSI GANAVIEDGV TLGDHVVIGA NCFVGKNSKI
160 170 180 190 200
GAYTQLWANV SVYHEVEIGQ HCLIQSGAVI GSDGFGYAND RGRWIKIPQV
210 220 230 240 250
GQVIIGNHVE IGACTCIDRG ALDPTVIEDN VIIDNLCQIA HNVHIGTGTA
260 270 280 290 300
VAGGVIMAGS LTVGRYCLIG GASVINGHME ICDKVTITGM GMVMRPITEP
310 320 330 340
GVYSSGIPLQ TNKEWRKTAA LTLGIDAMNK RLKALEKKFE KK
Length:342
Mass (Da):36,049
Last modified:June 1, 2001 - v1
Checksum:i117A01B0A04342D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK04078.1.
X74357 Genomic DNA. Translation: CAA52401.1.
PIRiS47342.
RefSeqiWP_005725095.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK04078; AAK04078; PM1994.
GeneIDi1245341.
KEGGipmu:PM1994.
PATRICi22873317. VBIPasMul88067_2017.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK04078.1.
X74357 Genomic DNA. Translation: CAA52401.1.
PIRiS47342.
RefSeqiWP_005725095.1. NC_002663.1.

3D structure databases

ProteinModelPortaliQ9CJL0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272843.PM1994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK04078; AAK04078; PM1994.
GeneIDi1245341.
KEGGipmu:PM1994.
PATRICi22873317. VBIPasMul88067_2017.

Phylogenomic databases

eggNOGiENOG4105D7M. Bacteria.
COG1044. LUCA.
HOGENOMiHOG000294339.
KOiK02536.
OMAiSYPAKIM.

Enzyme and pathway databases

UniPathwayiUPA00973.

Family and domain databases

CDDicd03352. LbH_LpxD. 1 hit.
HAMAPiMF_00523. LpxD. 1 hit.
InterProiIPR001451. Hexapep.
IPR018357. Hexapep_transf_CS.
IPR007691. LpxD.
IPR011004. Trimer_LpxA-like.
IPR020573. UDP_GlcNAc_AcTrfase_non-rep.
[Graphical view]
PfamiPF00132. Hexapep. 3 hits.
PF04613. LpxD. 1 hit.
[Graphical view]
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR01853. lipid_A_lpxD. 1 hit.
PROSITEiPS00101. HEXAPEP_TRANSFERASES. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLPXD_PASMU
AccessioniPrimary (citable) accession number: Q9CJL0
Secondary accession number(s): Q51923
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.