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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-2073-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:PM1997
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Lipid-A-disaccharide synthasePRO_0000190173Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272843.PM1997.

Structurei

3D structure databases

ProteinModelPortaliQ9CJK7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.Curated

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CJK7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKEIHKQPPT IAIVAGEVSG DILGAGLIRS LKVQYPHARF IGIAGPRMLA
60 70 80 90 100
EGAETLVDME ELSVMGLAEV VKHLPRLLKI RRQLIHTMLQ EKPDIFIGID
110 120 130 140 150
APDFNIDVEL KLKENGIKTI HYVSPSVWAW RQNRIHKIAK ATHLVLAFLP
160 170 180 190 200
FEKAFYDRFE VPCRFIGHTM ADAIALKPNR QEACEYLNLD ASQRYVAILV
210 220 230 240 250
GSRGSEVTFL AEPFLQAAKL LKQQYPDIQF LVPLINAKRR EQFEQIKAQV
260 270 280 290 300
APELELILLD GKARQAMIAA EATLLASGTA ALEAMLCKSP MVVGYRMKAT
310 320 330 340 350
TYFLAKRLVK TEYVSLPNLL ANEMLVPELI QEQCTAENLA EKLALYLSQE
360 370 380 390
ESALQQRHTL IQRFTDLHKL IQCDADKQAA QAVIALLEQE DK
Length:392
Mass (Da):44,054
Last modified:June 1, 2001 - v1
Checksum:i775F6357A648F910
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK04081.1.
RefSeqiNP_246936.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK04081; AAK04081; PM1997.
GeneIDi1245344.
KEGGipmu:PM1997.
PATRICi22873323. VBIPasMul88067_2020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE004439 Genomic DNA. Translation: AAK04081.1.
RefSeqiNP_246936.1. NC_002663.1.

3D structure databases

ProteinModelPortaliQ9CJK7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272843.PM1997.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK04081; AAK04081; PM1997.
GeneIDi1245344.
KEGGipmu:PM1997.
PATRICi22873323. VBIPasMul88067_2020.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiAPQEWAW.
OrthoDBiEOG6FBWZR.

Enzyme and pathway databases

UniPathwayiUPA00359; UER00481.
BioCyciPMUL272843:GC8W-2073-MONOMER.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.

Entry informationi

Entry nameiLPXB_PASMU
AccessioniPrimary (citable) accession number: Q9CJK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: February 4, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.