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Q9CJK7

- LPXB_PASMU

UniProt

Q9CJK7 - LPXB_PASMU

Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.By similarity

    Catalytic activityi

    UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. lipid A biosynthetic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciPMUL272843:GC8W-2073-MONOMER.
    UniPathwayiUPA00359; UER00481.

    Protein family/group databases

    CAZyiGT19. Glycosyltransferase Family 19.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lipid-A-disaccharide synthase (EC:2.4.1.182)
    Gene namesi
    Name:lpxB
    Ordered Locus Names:PM1997
    OrganismiPasteurella multocida (strain Pm70)
    Taxonomic identifieri272843 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
    ProteomesiUP000000809: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Lipid-A-disaccharide synthasePRO_0000190173Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272843.PM1997.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CJK7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LpxB family.Curated

    Phylogenomic databases

    eggNOGiCOG0763.
    HOGENOMiHOG000018003.
    KOiK00748.
    OMAiVSPITYR.
    OrthoDBiEOG6FBWZR.

    Family and domain databases

    HAMAPiMF_00392. LpxB.
    InterProiIPR003835. Glyco_trans_19.
    [Graphical view]
    PfamiPF02684. LpxB. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00215. lpxB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9CJK7-1 [UniParc]FASTAAdd to Basket

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    MKEIHKQPPT IAIVAGEVSG DILGAGLIRS LKVQYPHARF IGIAGPRMLA    50
    EGAETLVDME ELSVMGLAEV VKHLPRLLKI RRQLIHTMLQ EKPDIFIGID 100
    APDFNIDVEL KLKENGIKTI HYVSPSVWAW RQNRIHKIAK ATHLVLAFLP 150
    FEKAFYDRFE VPCRFIGHTM ADAIALKPNR QEACEYLNLD ASQRYVAILV 200
    GSRGSEVTFL AEPFLQAAKL LKQQYPDIQF LVPLINAKRR EQFEQIKAQV 250
    APELELILLD GKARQAMIAA EATLLASGTA ALEAMLCKSP MVVGYRMKAT 300
    TYFLAKRLVK TEYVSLPNLL ANEMLVPELI QEQCTAENLA EKLALYLSQE 350
    ESALQQRHTL IQRFTDLHKL IQCDADKQAA QAVIALLEQE DK 392
    Length:392
    Mass (Da):44,054
    Last modified:June 1, 2001 - v1
    Checksum:i775F6357A648F910
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004439 Genomic DNA. Translation: AAK04081.1.
    RefSeqiNP_246936.1. NC_002663.1.

    Genome annotation databases

    EnsemblBacteriaiAAK04081; AAK04081; PM1997.
    GeneIDi1245344.
    KEGGipmu:PM1997.
    PATRICi22873323. VBIPasMul88067_2020.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE004439 Genomic DNA. Translation: AAK04081.1 .
    RefSeqi NP_246936.1. NC_002663.1.

    3D structure databases

    ProteinModelPortali Q9CJK7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272843.PM1997.

    Protein family/group databases

    CAZyi GT19. Glycosyltransferase Family 19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK04081 ; AAK04081 ; PM1997 .
    GeneIDi 1245344.
    KEGGi pmu:PM1997.
    PATRICi 22873323. VBIPasMul88067_2020.

    Phylogenomic databases

    eggNOGi COG0763.
    HOGENOMi HOG000018003.
    KOi K00748.
    OMAi VSPITYR.
    OrthoDBi EOG6FBWZR.

    Enzyme and pathway databases

    UniPathwayi UPA00359 ; UER00481 .
    BioCyci PMUL272843:GC8W-2073-MONOMER.

    Family and domain databases

    HAMAPi MF_00392. LpxB.
    InterProi IPR003835. Glyco_trans_19.
    [Graphical view ]
    Pfami PF02684. LpxB. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00215. lpxB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Pm70.

    Entry informationi

    Entry nameiLPXB_PASMU
    AccessioniPrimary (citable) accession number: Q9CJK7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 1, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3