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Q9CJK7

- LPXB_PASMU

UniProt

Q9CJK7 - LPXB_PASMU

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Protein

Lipid-A-disaccharide synthase

Gene
lpxB, PM1997
Organism
Pasteurella multocida (strain Pm70)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPMUL272843:GC8W-2073-MONOMER.
UniPathwayiUPA00359; UER00481.

Protein family/group databases

CAZyiGT19. Glycosyltransferase Family 19.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthase (EC:2.4.1.182)
Gene namesi
Name:lpxB
Ordered Locus Names:PM1997
OrganismiPasteurella multocida (strain Pm70)
Taxonomic identifieri272843 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaePasteurella
ProteomesiUP000000809: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Lipid-A-disaccharide synthaseUniRule annotationPRO_0000190173Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272843.PM1997.

Structurei

3D structure databases

ProteinModelPortaliQ9CJK7.

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CJK7-1 [UniParc]FASTAAdd to Basket

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MKEIHKQPPT IAIVAGEVSG DILGAGLIRS LKVQYPHARF IGIAGPRMLA    50
EGAETLVDME ELSVMGLAEV VKHLPRLLKI RRQLIHTMLQ EKPDIFIGID 100
APDFNIDVEL KLKENGIKTI HYVSPSVWAW RQNRIHKIAK ATHLVLAFLP 150
FEKAFYDRFE VPCRFIGHTM ADAIALKPNR QEACEYLNLD ASQRYVAILV 200
GSRGSEVTFL AEPFLQAAKL LKQQYPDIQF LVPLINAKRR EQFEQIKAQV 250
APELELILLD GKARQAMIAA EATLLASGTA ALEAMLCKSP MVVGYRMKAT 300
TYFLAKRLVK TEYVSLPNLL ANEMLVPELI QEQCTAENLA EKLALYLSQE 350
ESALQQRHTL IQRFTDLHKL IQCDADKQAA QAVIALLEQE DK 392
Length:392
Mass (Da):44,054
Last modified:June 1, 2001 - v1
Checksum:i775F6357A648F910
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK04081.1.
RefSeqiNP_246936.1. NC_002663.1.

Genome annotation databases

EnsemblBacteriaiAAK04081; AAK04081; PM1997.
GeneIDi1245344.
KEGGipmu:PM1997.
PATRICi22873323. VBIPasMul88067_2020.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE004439 Genomic DNA. Translation: AAK04081.1 .
RefSeqi NP_246936.1. NC_002663.1.

3D structure databases

ProteinModelPortali Q9CJK7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272843.PM1997.

Protein family/group databases

CAZyi GT19. Glycosyltransferase Family 19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK04081 ; AAK04081 ; PM1997 .
GeneIDi 1245344.
KEGGi pmu:PM1997.
PATRICi 22873323. VBIPasMul88067_2020.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PMUL272843:GC8W-2073-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Pm70.

Entry informationi

Entry nameiLPXB_PASMU
AccessioniPrimary (citable) accession number: Q9CJK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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