Reviewed, UniProtKB/Swiss-Prot Q9CJH1 (MTLD_LACLA)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	LL0024
ORF Names:	L33416

Organism

Lactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP]

Taxonomic identifier

1360 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	385 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 385	385	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170708
Regions
	Nucleotide binding	4 – 15	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CJH1-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: C06C1B98324D6F67	FASTA	385	43,673
	10 20 30 40 50 60 MKKAVHFGAG NIGRGFIGEI LSKNGFDIHF VDTNKSIIAE LNNRHSYEIG IASSEHEKIS 70 80 90 100 110 120 VKAVSGINNS ENPEAVIEAI AKADILTTAI GPNVLPYIAE LIAKGLQKRK EEKVQSPLDI 130 140 150 160 170 180 IACENMIGGS EFLEEKVSDY LSESDKLYLS KFIGFPNAAV DRIVPAQKHK DVLYVEVEPF 190 200 210 220 230 240 SEWVIDASHL KNKEIKLEGV HYTTDLEPFI ERKLFSVNSG HAAVAYSSAY KGYKTILEGL 250 260 270 280 290 300 QDEEILNILK AVQKETRALL LAKWAQYFKQ DELIKYHELI ISRFSNPEII DEVSRVARTP 310 320 330 340 350 360 IRKLGYDERF IRPIRELNDR KLSYQNHLDI VGKIFAYHDE NDAQAIQLQE KLKITELPML 370 380 IEEVTGLSNQ KLILEIEKVI NHYKK

References

[1]

"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006242 Genomic DNA. Translation: AAK04122.1.
PIR	H86627.
RefSeq	NP_266180.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1113623.
GenomeReviews	Gene locus LL0024 in contig AE005176_GR.
KEGG	lla:L33416.
NMPDR	fig|272623.1.peg.25.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9CJH1.
OMA	Q9CJH1. VDRIVPN.
Enzyme and pathway databases
BioCyc	LLAC272623:L33416-MON.
BRENDA	1.1.1.17. 278870.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_LACLA

Accession

Primary (citable) accession number: Q9CJH1

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)