Q9CJD8 (Q9CJD8_LACLA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Dihydrolipoyl dehydrogenase RuleBase RU003692
EC=1.8.1.4 RuleBase RU003692

Gene names

Name:	pdhD EMBL AAK04157.1
Ordered Locus Names:	LL0059
ORF Names:	L0036 EMBL AAK04157.1

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	472 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Protein N(6)-(dihydrolipoyl)lysine + NAD+ = protein N(6)-(lipoyl)lysine + NADH. RuleBase RU003692
Cofactor	Binds 1 FAD per subunit By similarity. RuleBase RU003692
Miscellaneous	The active site is a redox-active disulfide bond By similarity. RuleBase RU003692
Sequence similarities	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. RuleBase RU003691

Ontologies

Keywords
Domain	Redox-active center RuleBase RU003691
Ligand	FAD RuleBase RU003691 Flavoprotein RuleBase RU003691 NAD RuleBase RU003692
Molecular function	Oxidoreductase RuleBase RU003691 EMBL AAK04157.1
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell redox homeostasis Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	dihydrolipoyl dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q9CJD8 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 3F7D7B3417B406DC	FASTA	472	49,867
	10 20 30 40 50 60 MVVGAQATEV DLVVIGSGPG GYVAAIRAAE LGKKVTIIEK DNVGGVCLNI GCIPSKALIN 70 80 90 100 110 120 IGHHYQESLE EEKGENPFGL SVGNVKLNWE SAQKWKQDKV VNQLTGGVKM LLKKHKVDVI 130 140 150 160 170 180 QGTAEFIDNN TINVEQEDGF QLLQFNDVII STGSRPIEIP SFPFGGRIID STGALSLPEV 190 200 210 220 230 240 PKHLIIVGGG VIGSELGGAY RMLGSKITIV EGLDHILNGF DKEMSDIIAN RVKSAGSEIF 250 260 270 280 290 300 TSAMAKSATQ TDKDVTLTFE VDGKEQTVTG DYLLVSVGRR PNTDLIGLNN TDVKLTDRGL 310 320 330 340 350 360 IEVDDSYATN VPHIYAIGDV VPGPMLAHKA SFQAKVAAAA IAGAEDDVDL HVALPAVAYT 370 380 390 400 410 420 TTELATVGET PESVKDRKDV KISKFPFAAN GRAISMNDTT GFLRLITETK EGALIGAQIV 430 440 450 460 470 GPGASDLISG LSLAIENGLT SKDISLTIQP HPTLGEAIMD TAELADGLPI HV

References

[1]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK04157.1.
PIR	C86632.
RefSeq	NP_266215.1. NC_002662.1.
3D structure databases
HSSP	HSSP built from PDB template 1EBD based on UniProtKB P11959.
ProteinModelPortal	Q9CJD8.
SMR	Q9CJD8. Positions 7-465.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1113662.
GenomeReviews	Gene locus LL0059 in contig AE005176_GR.
KEGG	lla:L0036.
NMPDR	fig|272623.1.peg.64.
PATRIC	22292252. VBILacLac136773_0064.
Phylogenomic databases
HOGENOM	HBG515043.
OMA	MDENSAQ.
ProtClustDB	PRK06416.
Family and domain databases
InterPro	IPR016156. FAD/NAD-linked_Rdtase_dimer. IPR013027. FAD_pyr_nucl-diS_OxRdtase. IPR006258. Lipoamide_DH. IPR004099. Pyr_nucl-diS_OxRdtase_dimer. IPR023753. Pyr_nucl-diS_OxRdtase_FAD/NAD. IPR012999. Pyr_OxRdtase_I_AS. IPR001327. Pyr_OxRdtase_NAD-bd_dom. [Graphical view]
Gene3D	G3DSA:3.30.390.30. Pyr_redox_dim. 1 hit.
KO	K00382.
PANTHER	PTHR22912:SF20. Lipoamide_DH. 1 hit.
Pfam	PF00070. Pyr_redox. 1 hit. PF07992. Pyr_redox_2. 1 hit. PF02852. Pyr_redox_dim. 1 hit. [Graphical view]
PRINTS	PR00368. FADPNR.
SUPFAM	SSF55424. FAD/NAD-linked_reductase_dimer. 1 hit.
TIGRFAMs	TIGR01350. Lipoamide_DH. 1 hit.
PROSITE	PS00076. PYRIDINE_REDOX_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9CJD8_LACLA

Accession

Primary (citable) accession number: Q9CJD8

Entry history

Integrated into UniProtKB/TrEMBL:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	December 14, 2011
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)