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Q9CJ76 (ARLY_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:LL0125
ORF Names:L0114
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length459 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006

Subcellular location

Cytoplasm By similarity HAMAP MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 459459Argininosuccinate lyase HAMAP MF_00006
PRO_0000137780

Sequences

Sequence LengthMass (Da)Tools
Q9CJ76 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: 85D14D00AE622426

FASTA45951,900
        10         20         30         40         50         60 
MVEKLWGGRF EASLDKQTEE FGASIKFEQR LAPFDLKGSL AHVKMLGETG IITTEESKKI 

        70         80         90        100        110        120 
AEGLKKVEEK LLNGQIEFKM ENEDIHMNME SYLHQEIGPL AGKLHTARSR NDQVVTDMHL 

       130        140        150        160        170        180 
YLKSILEAVL EALKVLRETI VKLAVNQIDT IMPGYTHLQH AQPISFGQHL MAYYQMLTRD 

       190        200        210        220        230        240 
FERFEFNVKH TDMNPLGAAA LAGTTFPIDR MLTTKLLGFE KAYDNSMDAV SDRDFILEFL 

       250        260        270        280        290        300 
SNASLLMMHL SRFCEELLLW SSHEFKFVSL SDTYSTGSSI MPQKKNPDMA ELIRGKTGRV 

       310        320        330        340        350        360 
YGNLTALLTV MKGLPLAYNK DFQEDKEGMF DSADTIITSL TVMNGMLSTL TVNRVNMEKS 

       370        380        390        400        410        420 
TEQDFSNATE LADYLATKGL PFRKAHELVG LLVLDCIKKG IYLQDVNLQD YQMLSPLINE 

       430        440        450 
DVYEVLKSRT AVSRRNSLGG TGFESVKKQI EEAKKELQI

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005176 Genomic DNA. Translation: AAK04223.1.
PIRE86640.
RefSeqNP_266281.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CJ76.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1113731.
GenomeReviewsGene locus LL0125 in contig AE005176_GR.
KEGGlla:L0114.
NMPDRfig|272623.1.peg.132.
PATRIC22292404. VBILacLac136773_0138.

Phylogenomic databases

HOGENOMHBG539632.
OMAEDIHTVI.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycLLAC272623:L0114-MONOMER.

Family and domain databases

HAMAPMF_00006. Arg_succ_lyase.
[Tree]
InterProIPR009049. Argininosuccinate_lyase.
IPR003031. D_crystallin.
IPR000362. Fumarate_lyase.
IPR020557. Fumarate_lyase_CS.
IPR008948. L-Aspartase-like.
IPR022761. Lyase1_N.
[Graphical view]
KOK01755.
PANTHERPTHR11444:SF3. argH. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00145. ARGSUCLYASE.
PR00149. FUMRATELYASE.
SUPFAMSSF48557. L-Aspartase-like. 1 hit.
TIGRFAMsTIGR00838. ArgH. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_LACLA
AccessionPrimary (citable) accession number: Q9CJ76
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: January 25, 2012
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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