Q9CJ17 (MSRB_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Peptide methionine sulfoxide reductase MsrB
EC=1.8.4.12

Alternative name(s):
Peptide-methionine (R)-S-oxide reductase

Gene names

Name:	msrB
Synonyms:	ybjA
Ordered Locus Names:	LL0189
ORF Names:	L192996

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	142 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (R)-S-oxide + thioredoxin. HAMAP MF_01400
Sequence similarities	Belongs to the MsrB Met sulfoxide reductase family.

Ontologies

Keywords
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	peptide-methionine (R)-S-oxide reductase activity Inferred from electronic annotation. Source: EC peptide-methionine-(S)-S-oxide reductase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 142	142	Peptide methionine sulfoxide reductase MsrB HAMAP MF_01400		PRO_0000140276
Sites
	Active site	115	1	Nucleophile By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CJ17 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: D93C104C1CBA7026	FASTA	142	16,144
	10 20 30 40 50 60 MEKEKLKKKL SLLAYRVTQE NGTEAPFANE FDDFFEQGLY VDVVSGEALF TSLDKYQSGC 70 80 90 100 110 120 GWPAFTQPID KGVVKEKRDK SLFMERTEVR SSNADSHLGH VFTDGPLDKG DLRYCINSAA 130 140 LRFVPFDQLE AEGYGEYVKY FS

References

[1]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK04287.1.
PIR	E86648.
RefSeq	NP_266345.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q9CJ17.
SMR	Q9CJ17. Positions 5-135.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1113798.
GenomeReviews	Gene locus LL0189 in contig AE005176_GR.
KEGG	lla:L192996.
NMPDR	fig|272623.1.peg.197.
PATRIC	22292550. VBILacLac136773_0210.
Phylogenomic databases
HOGENOM	HBG715255.
OMA	FTDGPVD.
ProtClustDB	PRK00222.
Enzyme and pathway databases
BioCyc	LLAC272623:L192996-MONOMER.
Family and domain databases
HAMAP	MF_01400. MsrB. [Tree]
InterPro	IPR002579. Methionine_sulphoxide_MsrB. IPR011057. Mss4-like. [Graphical view]
Gene3D	G3DSA:2.170.150.20. MsrB. 1 hit.
KO	K07305.
Pfam	PF01641. SelR. 1 hit. [Graphical view]
SUPFAM	SSF51316. Mss4_like. 1 hit.
TIGRFAMs	TIGR00357. TIGR00357. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MSRB_LACLA

Accession

Primary (citable) accession number: Q9CJ17

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program