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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei36 – 361SubstrateBy similarity
Binding sitei119 – 1191SubstrateBy similarity
Binding sitei157 – 1571SubstrateBy similarity
Binding sitei208 – 2081ATPBy similarity
Binding sitei296 – 2961ATP; via carbonyl oxygenBy similarity
Binding sitei327 – 3271ATPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi354 – 3574ATPBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-268-MONOMER.
UniPathwayiUPA00109; UER00185.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:pgk
Ordered Locus Names:LL0245
ORF Names:L0010
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 398398Phosphoglycerate kinasePRO_0000145955Add
BLAST

Proteomic databases

PRIDEiQ9CIW1.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi272623.L0010.

Structurei

3D structure databases

ProteinModelPortaliQ9CIW1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni21 – 233Substrate bindingBy similarity
Regioni59 – 624Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0126.
KOiK00927.
OMAiDAFGTCH.
OrthoDBiEOG64N9Z0.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CIW1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLTVKDVE LKGKKVLVRV DFNVPIKDGV ITNDNRITAA LPTIKYILEQ
60 70 80 90 100
GGRAVLFSHL GRVKEEADKA GKSLAPVAKA LSEKLGQDVV FPGTTRGAEL
110 120 130 140 150
EAAINELKDG EILLVENTRF EDIDGKKESK NDPELGKYWA SLGDGIFVND
160 170 180 190 200
AFGTAHRAHA SNVGISANVD KAVAGFLLEN EIAYIQEAVE APERPFVAIL
210 220 230 240 250
GGSKVSDKIG VIENLLSKAD KVIIGGGMAY TFLKAQGYEI GTSLVEDDKL
260 270 280 290 300
DLAKELLEKA AGKLILPLDH KVANAFAGYT EVKETADQNI PAGFMGLDVA
310 320 330 340 350
SKTIADYNTQ LEGAKTVVWN GPVGVFENTD FQAGTVGLME AIVKQPGVKS
360 370 380 390
IIGGGDSAAA AINLGYADKF SWISTGGGAS MELLEGKVLP GLAALTEK
Length:398
Mass (Da):42,070
Last modified:April 27, 2001 - v1
Checksum:i1AC9A433B05F2595
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK04343.1.
PIRiE86655.
RefSeqiNP_266401.1. NC_002662.1.
WP_010905233.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK04343; AAK04343; L0010.
GeneIDi1113855.
KEGGilla:L0010.
PATRICi22292670. VBILacLac136773_0270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK04343.1.
PIRiE86655.
RefSeqiNP_266401.1. NC_002662.1.
WP_010905233.1. NC_002662.1.

3D structure databases

ProteinModelPortaliQ9CIW1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L0010.

Proteomic databases

PRIDEiQ9CIW1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK04343; AAK04343; L0010.
GeneIDi1113855.
KEGGilla:L0010.
PATRICi22292670. VBILacLac136773_0270.

Phylogenomic databases

eggNOGiCOG0126.
KOiK00927.
OMAiDAFGTCH.
OrthoDBiEOG64N9Z0.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185.
BioCyciLLAC272623:GHSH-268-MONOMER.

Family and domain databases

Gene3Di3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPiMF_00145. Phosphoglyc_kinase.
InterProiIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERiPTHR11406. PTHR11406. 1 hit.
PfamiPF00162. PGK. 1 hit.
[Graphical view]
PIRSFiPIRSF000724. Pgk. 1 hit.
PRINTSiPR00477. PHGLYCKINASE.
SUPFAMiSSF53748. SSF53748. 1 hit.
PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiPGK_LACLA
AccessioniPrimary (citable) accession number: Q9CIW1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 27, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.