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Protein

HTH-type dhaKLM operon transcriptional activator DhaS

Gene

dhaS

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

In complex with DhaQ, upon activation by dihydroxyacetone, activates transcription of the dhaKLM operon. Binds the inverted repeat sequence 5'-GGACACATN6ATTTGTCC-3' located upstream of and partially overlapping with the -35 promoter sequence of the dhaKLM operon promoter.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi35 – 54H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type dhaKLM operon transcriptional activator DhaS
Gene namesi
Name:dhaS
Synonyms:dhaR
Ordered Locus Names:LL0247
ORF Names:L45062
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002705331 – 187HTH-type dhaKLM operon transcriptional activator DhaSAdd BLAST187

Proteomic databases

PaxDbiQ9CIV9.

Interactioni

Subunit structurei

Homodimer. Interacts with a homodimer of DhaQ.1 Publication

Protein-protein interaction databases

STRINGi272623.L45062.

Structurei

Secondary structure

1187
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi13 – 28Combined sources16
Helixi31 – 33Combined sources3
Helixi36 – 43Combined sources8
Helixi47 – 52Combined sources6
Helixi57 – 73Combined sources17
Helixi82 – 95Combined sources14
Helixi97 – 106Combined sources10
Helixi110 – 132Combined sources23
Helixi139 – 163Combined sources25
Helixi168 – 170Combined sources3
Helixi171 – 183Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IU5X-ray1.60A/B1-187[»]
ProteinModelPortaliQ9CIV9.
SMRiQ9CIV9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9CIV9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 72HTH tetR-typePROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000237283.
OMAiVCIENAS.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR012738. Tscrpt_reg_DhaS.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
TIGRFAMsiTIGR02366. DHAK_reg. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CIV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAFFLNMKK SIITQKIIAK AFKDLMQSNA YHQISVSDIM QTAKIRRQTF
60 70 80 90 100
YNYFQNQEEL LSWIFENDFA ELINDNSDYY GWQNELLLLL RYLDENQIFY
110 120 130 140 150
QKIFVIDKNF EHFFLIQWEN LLDKVIFDQE KKSDYHWSDL EKSFICRYNA
160 170 180
AAICAITRES IIRGNSLEKL YSQIVNLLLA QIKIFES
Length:187
Mass (Da):22,481
Last modified:June 1, 2001 - v1
Checksum:iFFECB2C823630D15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK04345.1.
PIRiG86655.

Genome annotation databases

EnsemblBacteriaiAAK04345; AAK04345; L45062.
PATRICi22292674. VBILacLac136773_0272.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK04345.1.
PIRiG86655.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IU5X-ray1.60A/B1-187[»]
ProteinModelPortaliQ9CIV9.
SMRiQ9CIV9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L45062.

Proteomic databases

PaxDbiQ9CIV9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK04345; AAK04345; L45062.
PATRICi22292674. VBILacLac136773_0272.

Phylogenomic databases

HOGENOMiHOG000237283.
OMAiVCIENAS.

Miscellaneous databases

EvolutionaryTraceiQ9CIV9.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
InterProiIPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR012738. Tscrpt_reg_DhaS.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
TIGRFAMsiTIGR02366. DHAK_reg. 1 hit.
PROSITEiPS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDHAS_LACLA
AccessioniPrimary (citable) accession number: Q9CIV9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: June 1, 2001
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.