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Q9CIT4

- ACMA_LACLA

UniProt

Q9CIT4 - ACMA_LACLA

Protein

Probable N-acetylmuramidase

Gene

acmA

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Required for cell separation during growth.By similarity

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    GO - Molecular functioni

    1. amidase activity Source: InterPro
    2. lysozyme activity Source: UniProtKB-EC

    GO - Biological processi

    1. barrier septum assembly Source: UniProtKB-KW
    2. cell wall macromolecule metabolic process Source: InterPro
    3. cytolysis Source: UniProtKB-KW
    4. defense response to bacterium Source: UniProtKB-KW
    5. peptidoglycan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Keywords - Biological processi

    Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation

    Enzyme and pathway databases

    BioCyciLLAC272623:GHSH-296-MONOMER.

    Protein family/group databases

    CAZyiCBM50. Carbohydrate-Binding Module Family 50.
    GH73. Glycoside Hydrolase Family 73.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable N-acetylmuramidase (EC:3.2.1.17)
    Alternative name(s):
    Autolysin
    Lysozyme
    Peptidoglycan hydrolase
    Gene namesi
    Name:acmA
    Ordered Locus Names:LL0272
    ORF Names:L68758
    OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    Taxonomic identifieri272623 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000002196: Chromosome

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 5757Sequence AnalysisAdd
    BLAST
    Chaini58 – 439382Probable N-acetylmuramidasePRO_0000012112Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi272623.L68758.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CIT4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati243 – 28543LysM 1Add
    BLAST
    Repeati323 – 36543LysM 2Add
    BLAST
    Repeati397 – 43943LysM 3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi287 – 2915Poly-Ser
    Compositional biasi370 – 3745Poly-Ser

    Domaini

    The LysM repeats are thought to be involved in peptidoglycan binding.

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 73 family.Curated
    Contains 3 LysM repeats.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    eggNOGiCOG1388.
    HOGENOMiHOG000033783.
    OMAiKAWRANA.
    OrthoDBiEOG6GTZPF.

    Family and domain databases

    Gene3Di3.10.350.10. 3 hits.
    InterProiIPR018392. LysM_dom.
    IPR013338. Lysozyme_subfam2_dom.
    IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
    [Graphical view]
    PfamiPF01832. Glucosaminidase. 1 hit.
    PF01476. LysM. 3 hits.
    [Graphical view]
    SMARTiSM00257. LysM. 3 hits.
    SM00047. LYZ2. 1 hit.
    [Graphical view]
    SUPFAMiSSF54106. SSF54106. 3 hits.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CIT4-1 [UniParc]FASTAAdd to Basket

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    MPVSRIKVKN RHLKKKAKKP LAFYKPATKF AGAVLIAGTL TTTHELLLQQ    50
    TSPMVQAATN STEAFIESIA ASAKPVADSN GLYPSVMIAQ AILESNWGSS 100
    QLSRAPYYNL FGIQGTYQGK SVVFKTQEYL NGKWVTKDMP FRVYPSFNQS 150
    FQDNAYVLKT TNFGNGPYYA KAWRANAATY QAATAALTGK YATDPNYGAS 200
    LNRIISQYNL TRFDGASSAG TSNSGGSTAT NTNNNSNTSS TTYTVKSGDT 250
    LWGISQKYGI SVAQIQSANN LKSTVIYIGQ KLVLTTSSSS SNTNSSTSSG 300
    NSAGTTTPTT SVTPAKPASQ TTIKVKSGDT LWGLSVKYKT TIAQLKSWNH 350
    LNSDTIFIGQ NLIVSQSAGS SSSSTGSSSA STSSTSNSSA ASNTSIHKVV 400
    KGDTLWGLSQ KSGSPIASIK AWNHLSSDTI LIGQYLRIK 439
    Length:439
    Mass (Da):46,592
    Last modified:June 1, 2001 - v1
    Checksum:iAE4551E4D04CB499
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK04370.1.
    PIRiH86658.
    RefSeqiNP_266428.1. NC_002662.1.

    Genome annotation databases

    EnsemblBacteriaiAAK04370; AAK04370; L68758.
    GeneIDi1113882.
    KEGGilla:L68758.
    PATRICi22292728. VBILacLac136773_0298.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK04370.1 .
    PIRi H86658.
    RefSeqi NP_266428.1. NC_002662.1.

    3D structure databases

    ProteinModelPortali Q9CIT4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272623.L68758.

    Protein family/group databases

    CAZyi CBM50. Carbohydrate-Binding Module Family 50.
    GH73. Glycoside Hydrolase Family 73.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK04370 ; AAK04370 ; L68758 .
    GeneIDi 1113882.
    KEGGi lla:L68758.
    PATRICi 22292728. VBILacLac136773_0298.

    Phylogenomic databases

    eggNOGi COG1388.
    HOGENOMi HOG000033783.
    OMAi KAWRANA.
    OrthoDBi EOG6GTZPF.

    Enzyme and pathway databases

    BioCyci LLAC272623:GHSH-296-MONOMER.

    Family and domain databases

    Gene3Di 3.10.350.10. 3 hits.
    InterProi IPR018392. LysM_dom.
    IPR013338. Lysozyme_subfam2_dom.
    IPR002901. MGlyc_endo_b_GlcNAc_like_dom.
    [Graphical view ]
    Pfami PF01832. Glucosaminidase. 1 hit.
    PF01476. LysM. 3 hits.
    [Graphical view ]
    SMARTi SM00257. LysM. 3 hits.
    SM00047. LYZ2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54106. SSF54106. 3 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
      Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
      Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IL1403.

    Entry informationi

    Entry nameiACMA_LACLA
    AccessioniPrimary (citable) accession number: Q9CIT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3