Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9CIT4 (ACMA_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable N-acetylmuramidase

EC=3.2.1.17
Alternative name(s):
Autolysin
Lysozyme
Peptidoglycan hydrolase
Gene names
Name:acmA
Ordered Locus Names:LL0272
ORF Names:L68758
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for cell separation during growth By similarity.

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subcellular location

Secreted By similarity.

Domain

The LysM repeats are thought to be involved in peptidoglycan binding.

Sequence similarities

Belongs to the glycosyl hydrolase 73 family.

Contains 3 LysM repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 5757 Potential
Chain58 – 439382Probable N-acetylmuramidase
PRO_0000012112

Regions

Repeat243 – 28543LysM 1
Repeat323 – 36543LysM 2
Repeat397 – 43943LysM 3
Compositional bias287 – 2915Poly-Ser
Compositional bias370 – 3745Poly-Ser

Sequences

Sequence LengthMass (Da)Tools
Q9CIT4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: AE4551E4D04CB499

FASTA43946,592
        10         20         30         40         50         60 
MPVSRIKVKN RHLKKKAKKP LAFYKPATKF AGAVLIAGTL TTTHELLLQQ TSPMVQAATN 

        70         80         90        100        110        120 
STEAFIESIA ASAKPVADSN GLYPSVMIAQ AILESNWGSS QLSRAPYYNL FGIQGTYQGK 

       130        140        150        160        170        180 
SVVFKTQEYL NGKWVTKDMP FRVYPSFNQS FQDNAYVLKT TNFGNGPYYA KAWRANAATY 

       190        200        210        220        230        240 
QAATAALTGK YATDPNYGAS LNRIISQYNL TRFDGASSAG TSNSGGSTAT NTNNNSNTSS 

       250        260        270        280        290        300 
TTYTVKSGDT LWGISQKYGI SVAQIQSANN LKSTVIYIGQ KLVLTTSSSS SNTNSSTSSG 

       310        320        330        340        350        360 
NSAGTTTPTT SVTPAKPASQ TTIKVKSGDT LWGLSVKYKT TIAQLKSWNH LNSDTIFIGQ 

       370        380        390        400        410        420 
NLIVSQSAGS SSSSTGSSSA STSSTSNSSA ASNTSIHKVV KGDTLWGLSQ KSGSPIASIK 

       430 
AWNHLSSDTI LIGQYLRIK 

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005176 Genomic DNA. Translation: AAK04370.1.
PIRH86658.
RefSeqNP_266428.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CIT4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L68758.

Protein family/group databases

CAZyCBM50. Carbohydrate-Binding Module Family 50.
GH73. Glycoside Hydrolase Family 73.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK04370; AAK04370; L68758.
GeneID1113882.
KEGGlla:L68758.
PATRIC22292728. VBILacLac136773_0298.

Phylogenomic databases

eggNOGCOG1388.
HOGENOMHOG000033783.
OMAKAWRANA.
OrthoDBEOG6GTZPF.
ProtClustDBCLSK2567551.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-296-MONOMER.

Family and domain databases

Gene3D3.10.350.10. 3 hits.
InterProIPR018392. LysM_dom.
IPR013338. Lysozyme_dom_subfam2.
IPR002901. Mano_Glyc_endo_b_GlcNAc.
[Graphical view]
PfamPF01832. Glucosaminidase. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTSM00257. LysM. 3 hits.
SM00047. LYZ2. 1 hit.
[Graphical view]
SUPFAMSSF54106. SSF54106. 3 hits.
ProtoNetSearch...

Entry information

Entry nameACMA_LACLA
AccessionPrimary (citable) accession number: Q9CIT4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries