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Protein

Probable N-acetylmuramidase

Gene

acmA

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Required for cell separation during growth.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Keywords - Biological processi

Cell cycle, Cell division, Cell wall biogenesis/degradation, Septation

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.
GH73. Glycoside Hydrolase Family 73.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable N-acetylmuramidase (EC:3.2.1.17)
Alternative name(s):
Autolysin
Lysozyme
Peptidoglycan hydrolase
Gene namesi
Name:acmA
Ordered Locus Names:LL0272
ORF Names:L68758
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 57Sequence analysisAdd BLAST57
ChainiPRO_000001211258 – 439Probable N-acetylmuramidaseAdd BLAST382

Proteomic databases

PaxDbiQ9CIT4.

Interactioni

Protein-protein interaction databases

STRINGi272623.L68758.

Structurei

3D structure databases

ProteinModelPortaliQ9CIT4.
SMRiQ9CIT4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini241 – 284LysM 1PROSITE-ProRule annotationAdd BLAST44
Domaini321 – 364LysM 2PROSITE-ProRule annotationAdd BLAST44
Domaini395 – 438LysM 3PROSITE-ProRule annotationAdd BLAST44

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi287 – 291Poly-Ser5
Compositional biasi370 – 374Poly-Ser5

Domaini

The LysM domains are thought to be involved in peptidoglycan binding.

Sequence similaritiesi

Belongs to the glycosyl hydrolase 73 family.Curated
Contains 3 LysM domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG4107X35. Bacteria.
COG1388. LUCA.
COG1705. LUCA.
HOGENOMiHOG000033783.
OMAiYKTTIAQ.

Family and domain databases

CDDicd00118. LysM. 3 hits.
Gene3Di3.10.350.10. 3 hits.
InterProiIPR018392. LysM_dom.
IPR002901. MGlyc_endo_b_GlcNAc-like_dom.
[Graphical view]
PfamiPF01832. Glucosaminidase. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
SM00047. LYZ2. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS51782. LYSM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CIT4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPVSRIKVKN RHLKKKAKKP LAFYKPATKF AGAVLIAGTL TTTHELLLQQ
60 70 80 90 100
TSPMVQAATN STEAFIESIA ASAKPVADSN GLYPSVMIAQ AILESNWGSS
110 120 130 140 150
QLSRAPYYNL FGIQGTYQGK SVVFKTQEYL NGKWVTKDMP FRVYPSFNQS
160 170 180 190 200
FQDNAYVLKT TNFGNGPYYA KAWRANAATY QAATAALTGK YATDPNYGAS
210 220 230 240 250
LNRIISQYNL TRFDGASSAG TSNSGGSTAT NTNNNSNTSS TTYTVKSGDT
260 270 280 290 300
LWGISQKYGI SVAQIQSANN LKSTVIYIGQ KLVLTTSSSS SNTNSSTSSG
310 320 330 340 350
NSAGTTTPTT SVTPAKPASQ TTIKVKSGDT LWGLSVKYKT TIAQLKSWNH
360 370 380 390 400
LNSDTIFIGQ NLIVSQSAGS SSSSTGSSSA STSSTSNSSA ASNTSIHKVV
410 420 430
KGDTLWGLSQ KSGSPIASIK AWNHLSSDTI LIGQYLRIK
Length:439
Mass (Da):46,592
Last modified:June 1, 2001 - v1
Checksum:iAE4551E4D04CB499
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK04370.1.
PIRiH86658.
RefSeqiNP_266428.1. NC_002662.1.
WP_010905256.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK04370; AAK04370; L68758.
GeneIDi1113882.
KEGGilla:L68758.
PATRICi22292728. VBILacLac136773_0298.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK04370.1.
PIRiH86658.
RefSeqiNP_266428.1. NC_002662.1.
WP_010905256.1. NC_002662.1.

3D structure databases

ProteinModelPortaliQ9CIT4.
SMRiQ9CIT4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272623.L68758.

Protein family/group databases

CAZyiCBM50. Carbohydrate-Binding Module Family 50.
GH73. Glycoside Hydrolase Family 73.

Proteomic databases

PaxDbiQ9CIT4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK04370; AAK04370; L68758.
GeneIDi1113882.
KEGGilla:L68758.
PATRICi22292728. VBILacLac136773_0298.

Phylogenomic databases

eggNOGiENOG4107X35. Bacteria.
COG1388. LUCA.
COG1705. LUCA.
HOGENOMiHOG000033783.
OMAiYKTTIAQ.

Family and domain databases

CDDicd00118. LysM. 3 hits.
Gene3Di3.10.350.10. 3 hits.
InterProiIPR018392. LysM_dom.
IPR002901. MGlyc_endo_b_GlcNAc-like_dom.
[Graphical view]
PfamiPF01832. Glucosaminidase. 1 hit.
PF01476. LysM. 3 hits.
[Graphical view]
SMARTiSM00257. LysM. 3 hits.
SM00047. LYZ2. 1 hit.
[Graphical view]
SUPFAMiSSF54106. SSF54106. 3 hits.
PROSITEiPS51782. LYSM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACMA_LACLA
AccessioniPrimary (citable) accession number: Q9CIT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: June 1, 2001
Last modified: November 30, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.