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Q9CIS4 (DAPEL_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyldiaminopimelate deacetylase
EC=3.5.1.47
Gene names
Name:yciA
Synonyms:dapL
Ordered Locus Names:LL0282
ORF Names:L80177
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Lactococcus ›

Protein attributes

Sequence length384 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate By similarity. HAMAP-Rule MF_01692

Catalytic activity

N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate. HAMAP-Rule MF_01692

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3. HAMAP-Rule MF_01692

Sequence similarities

Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 384384N-acetyldiaminopimelate deacetylase HAMAP-Rule MF_01692
PRO_0000376768

Sites

Active site691 By similarity
Active site1271Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CIS4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 1E3A34BF39BAFA8E

FASTA38443,100
        10         20         30         40         50         60 
MINLIEIRRQ LHQIPEIGLE EYETQKYLLA IIQELTQNKP FIQVRTWQTG ILVYLAGSQS 

        70         80         90        100        110        120 
QKTIGWRTDI DGLPIEELTD LPYASKNGRM HACGHDIHMT VALGLLEKMS ESQPRDNLLF 

       130        140        150        160        170        180 
LFQPAEENEA GGKLMYDARA FENWLPDEFY GLHVRPDLKV GDIATNQHTL FAGTCEVELS 

       190        200        210        220        230        240 
FIGTGGHAAF PHTANDALVA AAYFITQVQT IVSRNVDPLA SAVVTFGKME AGTTNNIIAE 

       250        260        270        280        290        300 
RAFLHGTIRS LTQEVNELTQ KRLRELANGI AQSFNMEIEL KLKQGGYLPV ENHPKLAKEL 

       310        320        330        340        350        360 
MEFFKKETKA NLIDIAPAMT GEDFGYLLSK IPGVMFWLGI DSDAPLHSQK MNPDEHVLNF 

       370        380 
SVDTISQFLQ FKVNRLSEGE KTIN

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005176 Genomic DNA. Translation: AAK04380.1.
PIRB86660.
RefSeqNP_266438.1. NC_002662.1.

3D structure databases

HSSPHSSP built from PDB template 1XMB based on UniProtKB P54970.
ProteinModelPortalQ9CIS4.
ModBaseSearch...

Protein-protein interaction databases

STRING272623.L80177.

Protein family/group databases

MEROPSM20.A27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK04380; AAK04380; L80177.
GeneID1113892.
KEGGlla:L80177.
PATRIC22292752. VBILacLac136773_0309.

Phylogenomic databases

eggNOGCOG1473.
HOGENOMHOG000241404.
KOK05823.
OMALANGIAQ.
ProtClustDBCLSK876719.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-373-MONOMER.
UniPathwayUPA00034; UER00024.

Family and domain databases

HAMAPMF_01692. DapEL.
InterProIPR023905. AcetylDAP_deacetylase.
IPR017439. Amidohydrolase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFPIRSF005962. Pept_M20D_amidohydro. 1 hit.
SUPFAMSSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMsTIGR01891. amidohydrolases. 1 hit.
PROSITEPS00758. ARGE_DAPE_CPG2_1. False negative.
PS00759. ARGE_DAPE_CPG2_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPEL_LACLA
AccessionPrimary (citable) accession number: Q9CIS4
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: June 1, 2001
Last modified: May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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