Reviewed, UniProtKB/Swiss-Prot Q9CIR9 (ADD_LACLA)

Names and origin

Protein names

Recommended name:
    Adenosine deaminase
    EC=3.5.4.4
Alternative name(s):
    Adenosine aminohydrolase

Gene names

Name:	add
Ordered Locus Names:	LL0287
ORF Names:	L87453

Organism

Lactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP]

Taxonomic identifier

1360 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenosine + H2O = inosine + NH3. HAMAP MF_00540
Sequence similarities	Belongs to the adenosine and AMP deaminases family.
Caution	Could lack activity as the potential active site Cys residue in position 257 is replaced by an Ala.

Ontologies

Keywords
Biological process	Nucleotide metabolism
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Adenosine deaminase HAMAP MF_00540		PRO_0000194372
Sites
	Active site	208	1	Potential
	Active site	290	1	Potential
	Active site	291	1	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CIR9-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: DCA9E8663D5EBA15	FASTA	352	40,067
	10 20 30 40 50 60 MKKKREKLVL KSEIIAQMPK VELHCHLDGS LSLSVIKELA KNAGIHMTMS DEEILEKAQA 70 80 90 100 110 120 PENTKNLLEY LQRFDFVLPL LQTYKNLELA AYDVVRQAAN DNIKYIEIRF APSQHLLENL 130 140 150 160 170 180 TLEEAVEAVI AGLSRAENDF DIRANALVCG LKQEPIQKLQ KLLPLFDKIP DEHLVGFDMA 190 200 210 220 230 240 GDELNYPQEK FVDLIHDIKI KGVNVTLHAG ECPACEKNIL DSIAMGASRI GHGIMTKNLS 250 260 270 280 290 300 EAEQKMMIEK QIVLEMAPTS NFQTKAVTEL AQYPFKELYD KGIHVTLNTD NRMVSATNLS 310 320 330 340 350 KEYEKISAWY PDFSLSDFEK INHYAIDGAF IGQEEKEELH QRFTKEYKKI SE

References

[1]

"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK04385.1.
PIR	G86660.
RefSeq	NP_266443.1.
3D structure databases
SMR	Q9CIR9. Positions 13-343.
ModBase	Search...
Genome annotation databases
GeneID	1113897.
GenomeReviews	Gene locus LL0287 in contig AE005176_GR.
KEGG	lla:L87453.
NMPDR	fig|272623.1.peg.295.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG630382.
OMA	KPGYAEL.
Enzyme and pathway databases
BioCyc	LLAC272623:L87453-MONOMER.
BRENDA	3.5.4.4. 278870.
Family and domain databases
HAMAP	MF_00540. A_deaminase. [Tree]
InterPro	IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view]
PANTHER	PTHR11409. A/AMP_deaminase. 1 hit.
Pfam	PF00962. A_deaminase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01430. aden_deam. 1 hit.
PROSITE	PS00485. A_DEAMINASE. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ADD_LACLA

Accession

Primary (citable) accession number: Q9CIR9

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	June 1, 2001
Last modified:	February 9, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)