Reviewed,
UniProtKB/Swiss-Prot Q9CIR9 (ADD_LACLA)
Last modified
February 9, 2010.
Version 45.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Adenosine deaminase EC=3.5.4.4 Alternative name(s): Adenosine aminohydrolase | ||||||
| Gene names |
| ||||||
| Organism | Lactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1360 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus |
Protein attributes
| Sequence length | 352 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | Adenosine + H2O = inosine + NH3. HAMAP MF_00540 |
| Sequence similarities | Belongs to the adenosine and AMP deaminases family. |
| Caution | Could lack activity as the potential active site Cys residue in position 257 is replaced by an Ala. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Nucleotide metabolism |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | purine ribonucleoside monophosphate biosynthetic process Inferred from electronic annotation. Source: HAMAP |
| Molecular function | adenosine deaminase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 352 | 352 | Adenosine deaminase HAMAP MF_00540 | PRO_0000194372 | |||||
Sites | |||||||||
| Active site | 208 | 1 | Potential | ||||||
| Active site | 290 | 1 | Potential | ||||||
| Active site | 291 | 1 | Potential | ||||||
Sequences
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References
| [1] | "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE005176 Genomic DNA. Translation: AAK04385.1. |
| PIR | G86660. |
| RefSeq | NP_266443.1. |
3D structure databases | |
| SMR | Q9CIR9. Positions 13-343. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1113897. |
| GenomeReviews | Gene locus LL0287 in contig AE005176_GR. |
| KEGG | lla:L87453. |
| NMPDR | fig|272623.1.peg.295. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG630382. |
| OMA | KPGYAEL. |
Enzyme and pathway databases | |
| BioCyc | LLAC272623:L87453-MONOMER. |
| BRENDA | 3.5.4.4. 278870. |
Family and domain databases | |
| HAMAP | MF_00540. A_deaminase. [Tree] |
| InterPro | IPR001365. A/AMP_deaminase. IPR006330. A_deaminase. [Graphical view] |
| PANTHER | PTHR11409. A/AMP_deaminase. 1 hit. |
| Pfam | PF00962. A_deaminase. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01430. aden_deam. 1 hit. |
| PROSITE | PS00485. A_DEAMINASE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | ADD_LACLA | ||||||||
| Accession | Primary (citable) accession number: Q9CIR9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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