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Q9CIR9 (ADD_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenosine deaminase
EC=3.5.4.4
Alternative name(s):
Adenosine aminohydrolase
Gene names
Name:add
Ordered Locus Names:LL0287
ORF Names:L87453
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length352 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenosine + H2O = inosine + NH3. HAMAP MF_00540

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00540

Sequence similarities

Belongs to the adenosine and AMP deaminases family. Adenosine deaminase subfamily.

Ontologies

Keywords
   Biological processNucleotide metabolism
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processpurine ribonucleoside monophosphate biosynthetic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenosine deaminase activity

Inferred from electronic annotation. Source: EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 352352Adenosine deaminase HAMAP MF_00540
PRO_0000194372

Sites

Active site2111Proton donor By similarity
Metal binding241Zinc; catalytic By similarity
Metal binding261Zinc; catalytic By similarity
Metal binding2081Zinc; catalytic By similarity
Metal binding2901Zinc; catalytic By similarity
Binding site261Substrate By similarity
Binding site281Substrate By similarity
Binding site1811Substrate; via amide nitrogen and carbonyl oxygen By similarity
Site2321Important for catalytic activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CIR9 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: DCA9E8663D5EBA15

FASTA35240,067
        10         20         30         40         50         60 
MKKKREKLVL KSEIIAQMPK VELHCHLDGS LSLSVIKELA KNAGIHMTMS DEEILEKAQA 

        70         80         90        100        110        120 
PENTKNLLEY LQRFDFVLPL LQTYKNLELA AYDVVRQAAN DNIKYIEIRF APSQHLLENL 

       130        140        150        160        170        180 
TLEEAVEAVI AGLSRAENDF DIRANALVCG LKQEPIQKLQ KLLPLFDKIP DEHLVGFDMA 

       190        200        210        220        230        240 
GDELNYPQEK FVDLIHDIKI KGVNVTLHAG ECPACEKNIL DSIAMGASRI GHGIMTKNLS 

       250        260        270        280        290        300 
EAEQKMMIEK QIVLEMAPTS NFQTKAVTEL AQYPFKELYD KGIHVTLNTD NRMVSATNLS 

       310        320        330        340        350 
KEYEKISAWY PDFSLSDFEK INHYAIDGAF IGQEEKEELH QRFTKEYKKI SE

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005176 Genomic DNA. Translation: AAK04385.1.
PIRG86660.
RefSeqNP_266443.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CIR9.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1113897.
GenomeReviewsGene locus LL0287 in contig AE005176_GR.
KEGGlla:L87453.
NMPDRfig|272623.1.peg.295.
PATRIC22292770. VBILacLac136773_0316.

Phylogenomic databases

HOGENOMHBG630382.
OMAITLECCA.
ProtClustDBPRK09358.

Enzyme and pathway databases

BioCycLLAC272623:L87453-MONOMER.

Family and domain databases

HAMAPMF_00540. A_deaminase.
[Tree]
InterProIPR001365. A/AMP_deaminase_dom.
IPR006330. A_deaminase.
[Graphical view]
KOK01488.
PANTHERPTHR11409:SF21. PTHR11409:SF21. 1 hit.
PfamPF00962. A_deaminase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01430. Aden_deam. 1 hit.
PROSITEPS00485. A_DEAMINASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADD_LACLA
AccessionPrimary (citable) accession number: Q9CIR9
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: June 1, 2001
Last modified: January 25, 2012
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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