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Q9CIQ1

- AMPN_LACLA

UniProt

Q9CIQ1 - AMPN_LACLA

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Protein

Aminopeptidase N

Gene

pepN

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Aminopeptidase with broad substrate specificity to several peptides. It has more affinity for oligopeptides than for dipeptides. It plays an essential role in the metabolism, it may be involved in nitrogen supply or protein turnover (By similarity).By similarity

Catalytic activityi

Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201SubstrateBy similarity
Metal bindingi288 – 2881Zinc; catalyticPROSITE-ProRule annotation
Active sitei289 – 2891Proton acceptorPROSITE-ProRule annotation
Metal bindingi292 – 2921Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi311 – 3111Zinc; catalyticPROSITE-ProRule annotation
Sitei375 – 3751Transition state stabilizerBy similarity

GO - Molecular functioni

  1. aminopeptidase activity Source: UniProtKB-KW
  2. metallopeptidase activity Source: UniProtKB-KW
  3. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-332-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Aminopeptidase N (EC:3.4.11.2)
Alternative name(s):
Alanine aminopeptidase
Lysyl aminopeptidase
Short name:
Lys-AP
Gene namesi
Name:pepN
Ordered Locus Names:LL0305
ORF Names:L102360
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

Subcellular locationi

Cytoplasm By similarity
Note: It may be secreted through an unknown mechanism.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 846846Aminopeptidase NPRO_0000095073Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi272623.L102360.

Structurei

3D structure databases

ProteinModelPortaliQ9CIQ1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni252 – 2565Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the peptidase M1 family.Curated

Phylogenomic databases

eggNOGiCOG0308.
HOGENOMiHOG000235375.
KOiK01256.
OMAiYLDINRE.
OrthoDBiEOG693GJ0.

Family and domain databases

InterProiIPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view]
PANTHERiPTHR11533. PTHR11533. 1 hit.
PfamiPF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view]
PRINTSiPR00756. ALADIPTASE.
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CIQ1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAVKRLIETF VPENYKIFLD IDRKTKKIKG QVAITGEAKD SVIAFHAKGL
60 70 80 90 100
HFSKVRAFSV DTNFIENEED EEIVVKIGET GRVTVSFEYE AELTDNMMGI
110 120 130 140 150
YPSYYEVNGE KKMLIGTQFE SHFARQAFPS IDEPEAKATF DLSVKFDEEE
160 170 180 190 200
GDIIVSNMPE LLNINGIHVF ERTVKMSSYL LAFVFGELQF KKGKTKSGVE
210 220 230 240 250
VGAFATKDHS EAALDFPLDI AIRSIEFYED YYKTPYPLPH SWHIALPDFS
260 270 280 290 300
AGAMENWGCI TYREVCMLVD PENATIQSKQ YVATVIAHEL AHQWFGDLVT
310 320 330 340 350
MQWWDDLWLN ESFANNMEYV CMDALEPSWN VWESFSISEA NMALNRDATD
360 370 380 390 400
GVQSVHVEVT HPDEIGTLFD PAIVYAKGSR LMVMLRKWLG DEDFAAGLAL
410 420 430 440 450
YFKRHQYGNT VGDNLWDALA EVSGKDVAAF MHSWVNQPGY PVVTAEVIDD
460 470 480 490 500
TLVLSQKQFF VGEGADKGRL WNVPLNTNWS GLPDLLSSEK VEIPGFAALK
510 520 530 540 550
AKNDGKALFL NDANMAHYII DYKGQLLTDL LSEVETLENV TKFQILQDRK
560 570 580 590 600
LLAKAGVISY ADVVNILPAF TNEESYLVNT GLSQLISELE LFVDEDSETE
610 620 630 640 650
KAFQSLVGKL FAKNYARLGW DKVAGESAGD ESLRGIVLSK TLYAENADAK
660 670 680 690 700
AKASQIFAAH KENLAGIPAD IRPIVLNNEI KTTNSAELVK TYRETYVKTS
710 720 730 740 750
LQEFKRELEG AVALIKDEKV IAELLESFKN ADIVKPQDIA FSWFYLLRND
760 770 780 790 800
FSQDAAWAWE KANWAFLEEK LGGDMSYDKF VIYPGNTFKT ADKLAEYKAF
810 820 830 840
FEPKLENQGL KRSIEMAIKQ ITARVALIDS QKADVDKSIK EISEKL
Length:846
Mass (Da):95,336
Last modified:June 1, 2001 - v1
Checksum:i25AB6453A6A2681D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK04403.1.
PIRiA86663.
RefSeqiNP_266461.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK04403; AAK04403; L102360.
GeneIDi1113915.
KEGGilla:L102360.
PATRICi22292808. VBILacLac136773_0335.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK04403.1 .
PIRi A86663.
RefSeqi NP_266461.1. NC_002662.1.

3D structure databases

ProteinModelPortali Q9CIQ1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L102360.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK04403 ; AAK04403 ; L102360 .
GeneIDi 1113915.
KEGGi lla:L102360.
PATRICi 22292808. VBILacLac136773_0335.

Phylogenomic databases

eggNOGi COG0308.
HOGENOMi HOG000235375.
KOi K01256.
OMAi YLDINRE.
OrthoDBi EOG693GJ0.

Enzyme and pathway databases

BioCyci LLAC272623:GHSH-332-MONOMER.

Family and domain databases

InterProi IPR024571. ERAP1-like_C_dom.
IPR001930. Peptidase_M1.
IPR014782. Peptidase_M1_N.
[Graphical view ]
PANTHERi PTHR11533. PTHR11533. 1 hit.
Pfami PF11838. ERAP1_C. 1 hit.
PF01433. Peptidase_M1. 1 hit.
[Graphical view ]
PRINTSi PR00756. ALADIPTASE.
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiAMPN_LACLA
AccessioniPrimary (citable) accession number: Q9CIQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: June 1, 2001
Last modified: November 26, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3