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Q9CIQ1

- AMPN_LACLA

UniProt

Q9CIQ1 - AMPN_LACLA

Protein

Aminopeptidase N

Gene

pepN

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Jun 2001)
      Previous versions | rss
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    Functioni

    Aminopeptidase with broad substrate specificity to several peptides. It has more affinity for oligopeptides than for dipeptides. It plays an essential role in the metabolism, it may be involved in nitrogen supply or protein turnover By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.

    Cofactori

    Binds 1 zinc ion per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201SubstrateBy similarity
    Metal bindingi288 – 2881Zinc; catalyticPROSITE-ProRule annotation
    Active sitei289 – 2891Proton acceptorPROSITE-ProRule annotation
    Metal bindingi292 – 2921Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi311 – 3111Zinc; catalyticPROSITE-ProRule annotation
    Sitei375 – 3751Transition state stabilizerBy similarity

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-KW
    2. metallopeptidase activity Source: UniProtKB-KW
    3. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Aminopeptidase, Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciLLAC272623:GHSH-332-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aminopeptidase N (EC:3.4.11.2)
    Alternative name(s):
    Alanine aminopeptidase
    Lysyl aminopeptidase
    Short name:
    Lys-AP
    Gene namesi
    Name:pepN
    Ordered Locus Names:LL0305
    ORF Names:L102360
    OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    Taxonomic identifieri272623 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000002196: Chromosome

    Subcellular locationi

    Cytoplasm By similarity
    Note: It may be secreted through an unknown mechanism.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 846846Aminopeptidase NPRO_0000095073Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRINGi272623.L102360.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CIQ1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni252 – 2565Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the peptidase M1 family.Curated

    Phylogenomic databases

    eggNOGiCOG0308.
    HOGENOMiHOG000235375.
    KOiK01256.
    OMAiYLDINRE.
    OrthoDBiEOG693GJ0.

    Family and domain databases

    InterProiIPR024571. ERAP1-like_C_dom.
    IPR001930. Peptidase_M1.
    IPR014782. Peptidase_M1_N.
    [Graphical view]
    PANTHERiPTHR11533. PTHR11533. 1 hit.
    PfamiPF11838. ERAP1_C. 1 hit.
    PF01433. Peptidase_M1. 1 hit.
    [Graphical view]
    PRINTSiPR00756. ALADIPTASE.
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9CIQ1-1 [UniParc]FASTAAdd to Basket

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    MAVKRLIETF VPENYKIFLD IDRKTKKIKG QVAITGEAKD SVIAFHAKGL    50
    HFSKVRAFSV DTNFIENEED EEIVVKIGET GRVTVSFEYE AELTDNMMGI 100
    YPSYYEVNGE KKMLIGTQFE SHFARQAFPS IDEPEAKATF DLSVKFDEEE 150
    GDIIVSNMPE LLNINGIHVF ERTVKMSSYL LAFVFGELQF KKGKTKSGVE 200
    VGAFATKDHS EAALDFPLDI AIRSIEFYED YYKTPYPLPH SWHIALPDFS 250
    AGAMENWGCI TYREVCMLVD PENATIQSKQ YVATVIAHEL AHQWFGDLVT 300
    MQWWDDLWLN ESFANNMEYV CMDALEPSWN VWESFSISEA NMALNRDATD 350
    GVQSVHVEVT HPDEIGTLFD PAIVYAKGSR LMVMLRKWLG DEDFAAGLAL 400
    YFKRHQYGNT VGDNLWDALA EVSGKDVAAF MHSWVNQPGY PVVTAEVIDD 450
    TLVLSQKQFF VGEGADKGRL WNVPLNTNWS GLPDLLSSEK VEIPGFAALK 500
    AKNDGKALFL NDANMAHYII DYKGQLLTDL LSEVETLENV TKFQILQDRK 550
    LLAKAGVISY ADVVNILPAF TNEESYLVNT GLSQLISELE LFVDEDSETE 600
    KAFQSLVGKL FAKNYARLGW DKVAGESAGD ESLRGIVLSK TLYAENADAK 650
    AKASQIFAAH KENLAGIPAD IRPIVLNNEI KTTNSAELVK TYRETYVKTS 700
    LQEFKRELEG AVALIKDEKV IAELLESFKN ADIVKPQDIA FSWFYLLRND 750
    FSQDAAWAWE KANWAFLEEK LGGDMSYDKF VIYPGNTFKT ADKLAEYKAF 800
    FEPKLENQGL KRSIEMAIKQ ITARVALIDS QKADVDKSIK EISEKL 846
    Length:846
    Mass (Da):95,336
    Last modified:June 1, 2001 - v1
    Checksum:i25AB6453A6A2681D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK04403.1.
    PIRiA86663.
    RefSeqiNP_266461.1. NC_002662.1.

    Genome annotation databases

    EnsemblBacteriaiAAK04403; AAK04403; L102360.
    GeneIDi1113915.
    KEGGilla:L102360.
    PATRICi22292808. VBILacLac136773_0335.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK04403.1 .
    PIRi A86663.
    RefSeqi NP_266461.1. NC_002662.1.

    3D structure databases

    ProteinModelPortali Q9CIQ1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272623.L102360.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK04403 ; AAK04403 ; L102360 .
    GeneIDi 1113915.
    KEGGi lla:L102360.
    PATRICi 22292808. VBILacLac136773_0335.

    Phylogenomic databases

    eggNOGi COG0308.
    HOGENOMi HOG000235375.
    KOi K01256.
    OMAi YLDINRE.
    OrthoDBi EOG693GJ0.

    Enzyme and pathway databases

    BioCyci LLAC272623:GHSH-332-MONOMER.

    Family and domain databases

    InterProi IPR024571. ERAP1-like_C_dom.
    IPR001930. Peptidase_M1.
    IPR014782. Peptidase_M1_N.
    [Graphical view ]
    PANTHERi PTHR11533. PTHR11533. 1 hit.
    Pfami PF11838. ERAP1_C. 1 hit.
    PF01433. Peptidase_M1. 1 hit.
    [Graphical view ]
    PRINTSi PR00756. ALADIPTASE.
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
      Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
      Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IL1403.

    Entry informationi

    Entry nameiAMPN_LACLA
    AccessioniPrimary (citable) accession number: Q9CIQ1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 7, 2004
    Last sequence update: June 1, 2001
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3