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Q9CIL4 (Q9CIL4_LACLA) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase RuleBase RU004136
EC=6.3.2.10 RuleBase RU004136
Gene names
Name:murF EMBL AAK04440.1
Ordered Locus Names:LL0342
ORF Names:L141766 EMBL AAK04440.1
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length440 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein By similarity. RuleBase RU004136

Catalytic activity

ATP + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine. RuleBase RU004136

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. RuleBase RU004136

Subcellular location

Cytoplasm By similarity RuleBase RU004136.

Sequence similarities

Belongs to the MurCDEF family. RuleBase RU003630

Sequences

Sequence LengthMass (Da)Tools
Q9CIL4 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 98CCF80B1535BA73

FASTA44048,823
        10         20         30         40         50         60 
MKLTIHEIAQ VVGAKNDWSQ LADLSVNKIE FDSRLIEKGD IFLPLKGARD GHDFIEIAFD 

        70         80         90        100        110        120 
NGAIISFSEK EVEQAHLLVD DNLLAFQKLA KYYLEKTKVP VIAVTGSNGK TTTKDMIAAV 

       130        140        150        160        170        180 
LSKKFKTYKT QGNHNNEIGL PYTILHMPDD TEKLVLEMGM DHPGDIDFLS ELAKPELAVI 

       190        200        210        220        230        240 
TLIGEAHLEH MGSRENIAKG KMGITAGLHG ELIAPADPII NAFIPDNQKI IRFGLPGEDL 

       250        260        270        280        290        300 
FITKLVEHKE KLTFETNFLD ESITIPVPGK YNATNAMLAA FVGLHYGLSE AEIKKALKEV 

       310        320        330        340        350        360 
ELTRNRTEWK KAKNGADLLS DVYNANPTAM RLILETFQAI PKNENGRKIA VLADMLELGP 

       370        380        390        400        410        420 
SAAQLHKDIL KSIDFNKIDK VYLYGEMMKN LAEISTDKAV SYFTDLDLLT ESLSADLKPT 

       430        440 
DQVLFKGSNS MKLSEVVEKL

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005176 Genomic DNA. Translation: AAK04440.1.
PIRF86667.
RefSeqNP_266498.1. NC_002662.1.

3D structure databases

HSSPHSSP built from PDB template 1GG4 based on UniProtKB P11880.
ProteinModelPortalQ9CIL4.
SMRQ9CIL4. Positions 1-440.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1113953.
GenomeReviewsGene locus LL0342 in contig AE005176_GR.
KEGGlla:L141766.
NMPDRfig|272623.1.peg.350.
PATRIC22292888. VBILacLac136773_0375.

Phylogenomic databases

HOGENOMHBG617121.
OMAYAVIEMG.
ProtClustDBCLSK876736.

Family and domain databases

InterProIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR000713. Mur_ligase_N.
IPR005863. UDP-N-AcMur-pentapeptide_synth.
[Graphical view]
Gene3DG3DSA:3.90.190.20. Mur_ligase_C. 1 hit.
G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit.
KOK01929.
PANTHERPTHR23135:SF3. MurF. 1 hit.
PfamPF01225. Mur_ligase. 1 hit.
PF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMSSF53244. Mur_ligase_C. 1 hit.
SSF53623. Mur_ligase_cen. 1 hit.
TIGRFAMsTIGR01143. MurF. 1 hit.
ProtoNetSearch...

Entry information

Entry nameQ9CIL4_LACLA
AccessionPrimary (citable) accession number: Q9CIL4
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: December 14, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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