Q9CIG4 (KTHY_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	LL0398
ORF Names:	L3846

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	211 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW thymidylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 211	211	Thymidylate kinase HAMAP MF_00165		PRO_0000155288
Regions
	Nucleotide binding	10 – 17	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CIG4 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 1CC1F2C5ED9B2A55	FASTA	211	23,999
	10 20 30 40 50 60 MNGILISLEG PDGAGKTTVL KEILPEIQKM KREIVPTREP GGVRVAEEIR QIILDPKNTD 70 80 90 100 110 120 IDSKTELMLF AAARRLHMQE KMLPALQAGK VVIVDRFIDS SVAYQGYGRD LGVEVVDWLN 130 140 150 160 170 180 YFATDGLKPD LTLYFDVDTD VALERIMKNR ADEVNRLDLE RAEMHRKVRE GYLEIVVKEP 190 200 210 ERFVKIDASQ PLEKVVADTL SVLKKRFVSE F

References

[1]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK04496.1.
PIR	F86674.
RefSeq	NP_266554.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q9CIG4.
SMR	Q9CIG4. Positions 4-207.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1114009.
GenomeReviews	Gene locus LL0398 in contig AE005176_GR.
KEGG	lla:L3846.
NMPDR	fig|272623.1.peg.406.
PATRIC	22293002. VBILacLac136773_0432.
Phylogenomic databases
HOGENOM	HBG626009.
OMA	SENTFPD.
ProtClustDB	PRK00698.
Enzyme and pathway databases
BioCyc	LLAC272623:L3846-MONOMER.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase. [Tree]
InterPro	IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
KO	K00943.
PANTHER	PTHR10344. Thymidylate_kin. 1 hit.
Pfam	PF02223. Thymidylate_kin. 1 hit. [Graphical view]
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_LACLA

Accession

Primary (citable) accession number: Q9CIG4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program