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Q9CID5

- TREPP_LACLA

UniProt

Q9CID5 - TREPP_LACLA

Protein

Trehalose 6-phosphate phosphorylase

Gene

trePP

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of trehalose 6-phosphate into glucose 1-phosphate and glucose 6-phosphate.

    Catalytic activityi

    Alpha,alpha-trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate.

    pH dependencei

    Optimum pH is 6.3.

    Temperature dependencei

    Optimum temperature is 35 degrees Celsius.

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. trehalose 6-phosphate phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BioCyciLLAC272623:GHSH-458-MONOMER.
    MetaCyc:MONOMER-5861.
    SABIO-RKQ9CID5.

    Protein family/group databases

    CAZyiGH65. Glycoside Hydrolase Family 65.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Trehalose 6-phosphate phosphorylase (EC:2.4.1.216)
    Short name:
    TrePP
    Gene namesi
    Name:trePP
    Ordered Locus Names:LL0428
    ORF Names:L39593
    OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    Taxonomic identifieri272623 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000002196: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 769768Trehalose 6-phosphate phosphorylasePRO_0000108014Add
    BLAST

    Proteomic databases

    PRIDEiQ9CID5.

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    STRINGi272623.L39593.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CID5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 65 family.Curated

    Phylogenomic databases

    eggNOGiCOG1554.
    HOGENOMiHOG000237472.
    KOiK03731.
    OMAiRTVDYYL.
    OrthoDBiEOG62C99Q.

    Family and domain databases

    Gene3Di1.50.10.10. 1 hit.
    2.70.98.40. 1 hit.
    InterProiIPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR005194. Glyco_hydro_65_C.
    IPR005195. Glyco_hydro_65_M.
    IPR005196. Glyco_hydro_65_N.
    IPR017045. Malt_Pase/Glycosyl_Hdrlase.
    [Graphical view]
    PfamiPF03633. Glyco_hydro_65C. 1 hit.
    PF03632. Glyco_hydro_65m. 1 hit.
    PF03636. Glyco_hydro_65N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF036289. Glycosyl_hydrolase_malt_phosph. 1 hit.
    SUPFAMiSSF48208. SSF48208. 1 hit.
    SSF74650. SSF74650. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CID5-1 [UniParc]FASTAAdd to Basket

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    MTEKDWIIQY DKKEVGKRSY GQESLMSLGN GYLGLRGAPL WSTCSDNHYP    50
    GLYVAGVFNR TSTEVAGHDV INEDMVNWPN PQLIKVYIDG ELVDFEASVE 100
    KQATIDFKNA LQIERYQVKL AKGNLTLVTT KFVDPINFHD FGFVGEIIAD 150
    FSCKLRIETF TDGSVLNQNV ERYRAFDSKE FEVTKISKGL LVAKTRTSEI 200
    ELAIASKSFL NGLAFPKIDS ENDEILAEAI EIDLQKNQEV QFDKTIVIAS 250
    SYESKNPVEF VLTELSATSV SKIQENNTNY WEKVWSDADI VIESDHEDLQ 300
    RMVRMNIFHI RQAAQHGANQ FLDASVGSRG LTGEGYRGHI FWDEIFVLPY 350
    YAANEPETAR DLLLYRINRL TAAQENAKVD GEKGAMFPWQ SGLIGDEQSQ 400
    FVHLNTVNNE WEPDNSRRQR HVSLAIVYNL WIYSQLTEDE SILTDGGLDL 450
    IIETTKFWLN KAELGDDGRY HIDGVMGPDE YHEAYPGQEG GICDNAYTNL 500
    MLTWQLNWLT ELSEKGFEIP KELLEKAQKV RKKLYLDIDE NGVIAQYAKY 550
    FELKEVDFAA YEAKYGDIHR IDRLMKAEGI SPDEYQVAKQ ADTLMLIYNL 600
    GQEHVTKLVK QLAYELPENW LKVNRDYYLA RTVHGSTTSR PVFAGIDVKL 650
    GDFDEALDFL ITAIGSDYYD IQGGTTAEGV HIGVMGETLE VIQNEFAGLS 700
    LREGQFAIAP YLPKSWTKLK FNQIFRGTKV EILIENGQLL LTASADLLTK 750
    VYDDEVQLKA GVQTKFDLK 769
    Length:769
    Mass (Da):87,267
    Last modified:January 23, 2007 - v3
    Checksum:i562D096E3A6CBB72
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti703 – 7031E → D in strain: ATCC 19435.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18267 Genomic DNA. Translation: CAA77100.1.
    AE005176 Genomic DNA. Translation: AAK04526.1.
    PIRiD86678.
    RefSeqiNP_266584.1. NC_002662.1.

    Genome annotation databases

    EnsemblBacteriaiAAK04526; AAK04526; L39593.
    GeneIDi1114040.
    KEGGilla:L39593.
    PATRICi22293072. VBILacLac136773_0466.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y18267 Genomic DNA. Translation: CAA77100.1 .
    AE005176 Genomic DNA. Translation: AAK04526.1 .
    PIRi D86678.
    RefSeqi NP_266584.1. NC_002662.1.

    3D structure databases

    ProteinModelPortali Q9CID5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272623.L39593.

    Protein family/group databases

    CAZyi GH65. Glycoside Hydrolase Family 65.

    Proteomic databases

    PRIDEi Q9CID5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK04526 ; AAK04526 ; L39593 .
    GeneIDi 1114040.
    KEGGi lla:L39593.
    PATRICi 22293072. VBILacLac136773_0466.

    Phylogenomic databases

    eggNOGi COG1554.
    HOGENOMi HOG000237472.
    KOi K03731.
    OMAi RTVDYYL.
    OrthoDBi EOG62C99Q.

    Enzyme and pathway databases

    BioCyci LLAC272623:GHSH-458-MONOMER.
    MetaCyc:MONOMER-5861.
    SABIO-RK Q9CID5.

    Family and domain databases

    Gene3Di 1.50.10.10. 1 hit.
    2.70.98.40. 1 hit.
    InterProi IPR008928. 6-hairpin_glycosidase-like.
    IPR012341. 6hp_glycosidase.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR005194. Glyco_hydro_65_C.
    IPR005195. Glyco_hydro_65_M.
    IPR005196. Glyco_hydro_65_N.
    IPR017045. Malt_Pase/Glycosyl_Hdrlase.
    [Graphical view ]
    Pfami PF03633. Glyco_hydro_65C. 1 hit.
    PF03632. Glyco_hydro_65m. 1 hit.
    PF03636. Glyco_hydro_65N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF036289. Glycosyl_hydrolase_malt_phosph. 1 hit.
    SUPFAMi SSF48208. SSF48208. 1 hit.
    SSF74650. SSF74650. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Trehalose-6-phosphate phosphorylase is part of a novel metabolic pathway for trehalose utilization in Lactococcus lactis."
      Andersson U., Levander F., Raedstroem P.
      J. Biol. Chem. 276:42707-42713(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 2-9, CHARACTERIZATION.
      Strain: ATCC 19435 / DSM 20481 / NCDO 604 / NCIB 6681 / NCTC 6681.
    2. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
      Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
      Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IL1403.

    Entry informationi

    Entry nameiTREPP_LACLA
    AccessioniPrimary (citable) accession number: Q9CID5
    Secondary accession number(s): Q9ZAG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 77 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3