Reviewed,
UniProtKB/Swiss-Prot Q9CI20 (SPX1_LACLA)
Last modified
June 16, 2009.
Version 42.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Regulatory protein spx 1 | ||||||
| Gene names |
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| Organism | Lactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 1360 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus |
Protein attributes
| Sequence length | 128 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress By similarity. |
| Subcellular location | Cytoplasm Probable. |
| Sequence similarities | Belongs to the arsC family. Spx subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Cytoplasm |
| Domain | Redox-active center |
| PTM | Disulfide bond |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcriptionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | transcription regulator activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 128 | 128 | Regulatory protein spx 1 HAMAP MF_01132 | PRO_0000162553 | |||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 10 ↔ 13 | Redox-active Potential | |||||||||
Sequences
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References
| [1] | "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403. |
Cross-references
Sequence databases | |
|---|---|
| AE006288 Genomic DNA. Translation: AAK04644.1. | |
| PIR | B86693. |
| RefSeq | NP_266702.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1114165. |
| GenomeReviews | Gene locus LL0546 in contig AE005176_GR. |
| KEGG | lla:L132585. |
| NMPDR | fig|272623.1.peg.561. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q9CI20. |
| OMA | Q9CI20. FTERNIF. |
Enzyme and pathway databases | |
| BioCyc | LLAC272623:L132585-MON. |
Family and domain databases | |
| HAMAP | MF_01132. [Tree] |
| InterPro | IPR006660. Arsenate_reductase-like. IPR006504. CHP1617_ArsC_rel. IPR012335. Thioredoxin_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| Pfam | PF03960. ArsC. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01617. arsC_related. 1 hit. |
| PROSITE | PS51353. ARSC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SPX1_LACLA | ||||||||
| Accession | Primary (citable) accession number: Q9CI20 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||

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