Q9CI20 (SPX1_LACLA) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 64.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Regulatory protein spx 1 | ||||||
| Gene names |
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| Organism | Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) | ||||||
| Taxonomic identifier | 272623 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus |
Protein attributes
| Sequence length | 128 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress By similarity. HAMAP MF_01132 |
| Subcellular location | Cytoplasm Probable HAMAP MF_01132. |
| Sequence similarities | Belongs to the ArsC family. Spx subfamily. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Transcription Transcription regulation |
| Cellular component | Cytoplasm |
| Domain | Redox-active center |
| PTM | Disulfide bond |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro transcription, DNA-dependentInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 128 | 128 | Regulatory protein spx 1 HAMAP MF_01132 | PRO_0000162553 | |||||||
Amino acid modifications | |||||||||||
| Disulfide bond | 10 ↔ 13 | Redox-active Potential | |||||||||
Sequences
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References
| [1] | "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE005176 Genomic DNA. Translation: AAK04644.1. |
| PIR | B86693. |
| RefSeq | NP_266702.1. NC_002662.1. |
3D structure databases | |
| ProteinModelPortal | Q9CI20. |
| SMR | Q9CI20. Positions 1-117. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1114165. |
| GenomeReviews | Gene locus LL0546 in contig AE005176_GR. |
| KEGG | lla:L132585. |
| NMPDR | fig|272623.1.peg.561. |
| PATRIC | 22293314. VBILacLac136773_0584. |
Phylogenomic databases | |
| HOGENOM | HBG734370. |
| OMA | FTERNIF. |
| ProtClustDB | CLSK697282. |
Enzyme and pathway databases | |
| BioCyc | LLAC272623:L132585-MONOMER. |
Family and domain databases | |
| HAMAP | MF_01132. SpxA. [Tree] |
| InterPro | IPR006660. Arsenate_reductase-like. IPR012336. Thioredoxin-like_fold. IPR023731. Tscrpt_reg_Spx. IPR006504. Tscrpt_reg_Spx/MgsR. [Graphical view] |
| Gene3D | G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit. |
| KO | K00537. |
| Pfam | PF03960. ArsC. 1 hit. [Graphical view] |
| SUPFAM | SSF52833. Thiordxn-like_fd. 1 hit. |
| TIGRFAMs | TIGR01617. ArsC_related. 1 hit. |
| PROSITE | PS51353. ARSC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SPX1_LACLA | ||||||||
| Accession | Primary (citable) accession number: Q9CI20 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| SIMILARITY comments Index of protein domains and families |

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