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Q9CI17 (MURA1_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1

EC=2.5.1.7
Alternative name(s):
Enoylpyruvate transferase 1
UDP-N-acetylglucosamine enolpyruvyl transferase 1
Short name=EPT 1
Gene names
Name:murA1
Synonyms:murA
Ordered Locus Names:LL0549
ORF Names:L134243
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP MF_00111

Catalytic activity

Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111

Subcellular location

Cytoplasm Probable HAMAP MF_00111.

Sequence similarities

Belongs to the EPSP synthase family. MurA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 427427UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP MF_00111
PRO_0000178879

Sites

Active site1211Proton donor By similarity

Amino acid modifications

Modified residue12112-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CI17 [UniParc].

Last modified April 27, 2001. Version 1.
Checksum: 79EA8B2F476F422E

FASTA42745,772
        10         20         30         40         50         60 
MMDKIIVKGG QTKLQGEVEI EGAKNAVLPL LAATLLASEG EVVLTNVPIL SDVFMMNNLV 

        70         80         90        100        110        120 
NHLGTAISFD QEAKKIIAKS NSEIKTTAPY EYVSKMRASI VVMGPILARN GQARVSMPGG 

       130        140        150        160        170        180 
CSIGSRPIDL HLRGFEQMGA TITQNAGYIE AKADKLKGAH IYLDFPSVGA TQNLILAATL 

       190        200        210        220        230        240 
ADGTTTLENA AREPEIVDLA NLLNKMGANV KGAGTDTIII KGVEKMHGAN HSVVQDRIEA 

       250        260        270        280        290        300 
GTFMVAAAMT QGDVLIKDAI AEHNRPLISK LSEMGVNFIQ EESGLRVVGP EKLKATSVKT 

       310        320        330        340        350        360 
LPHPGFPTDM QSQMTAAQAV AVGESVMVET VFENRFQHLK EMRRIGLEVD ITRNTALIQG 

       370        380        390        400        410        420 
NSNLQGAAVK STDLRASAAL ILLGLVAKGQ TTVRRLSHLD RGYYKFHEKL KALGADIIRV 


EDEDGEG 

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005176 Genomic DNA. Translation: AAK04647.1.
PIRE86693.
RefSeqNP_266705.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CI17.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1114168.
GenomeReviewsGene locus LL0549 in contig AE005176_GR.
KEGGlla:L134243.
NMPDRfig|272623.1.peg.564.
PATRIC22293320. VBILacLac136773_0587.

Phylogenomic databases

HOGENOMHBG482701.
OMAETEILNA.
ProtClustDBPRK09369.

Enzyme and pathway databases

BioCycLLAC272623:L134243-MONOMER.

Family and domain databases

HAMAPMF_00111. MurA.
[Tree]
InterProIPR001986. Enolpyruvate_Tfrase_dom.
IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b.
IPR005750. UDP_GlcNAc_COvinyl_MurA.
[Graphical view]
Gene3DG3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KOK00790.
PANTHERPTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
PfamPF00275. EPSP_synthase. 1 hit.
[Graphical view]
SUPFAMSSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMsTIGR01072. MurA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMURA1_LACLA
AccessionPrimary (citable) accession number: Q9CI17
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families