Q9CI17 (MURA1_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
EC=2.5.1.7

Alternative name(s):
Enoylpyruvate transferase 1
UDP-N-acetylglucosamine enolpyruvyl transferase 1
Short name=EPT 1

Gene names

Name:	murA1
Synonyms:	murA
Ordered Locus Names:	LL0549
ORF Names:	L134243

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity. HAMAP MF_00111
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111
Subcellular location	Cytoplasm Probable HAMAP MF_00111.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP MF_00111		PRO_0000178879
Sites
	Active site	121	1	Proton donor By similarity
Amino acid modifications
	Modified residue	121	1	2-(S-cysteinyl)pyruvic acid O-phosphothioketal By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CI17 [UniParc]. Last modified April 27, 2001. Version 1. Checksum: 79EA8B2F476F422E	FASTA	427	45,772
	10 20 30 40 50 60 MMDKIIVKGG QTKLQGEVEI EGAKNAVLPL LAATLLASEG EVVLTNVPIL SDVFMMNNLV 70 80 90 100 110 120 NHLGTAISFD QEAKKIIAKS NSEIKTTAPY EYVSKMRASI VVMGPILARN GQARVSMPGG 130 140 150 160 170 180 CSIGSRPIDL HLRGFEQMGA TITQNAGYIE AKADKLKGAH IYLDFPSVGA TQNLILAATL 190 200 210 220 230 240 ADGTTTLENA AREPEIVDLA NLLNKMGANV KGAGTDTIII KGVEKMHGAN HSVVQDRIEA 250 260 270 280 290 300 GTFMVAAAMT QGDVLIKDAI AEHNRPLISK LSEMGVNFIQ EESGLRVVGP EKLKATSVKT 310 320 330 340 350 360 LPHPGFPTDM QSQMTAAQAV AVGESVMVET VFENRFQHLK EMRRIGLEVD ITRNTALIQG 370 380 390 400 410 420 NSNLQGAAVK STDLRASAAL ILLGLVAKGQ TTVRRLSHLD RGYYKFHEKL KALGADIIRV EDEDGEG

References

[1]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK04647.1.
PIR	E86693.
RefSeq	NP_266705.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q9CI17.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1114168.
GenomeReviews	Gene locus LL0549 in contig AE005176_GR.
KEGG	lla:L134243.
NMPDR	fig|272623.1.peg.564.
PATRIC	22293320. VBILacLac136773_0587.
Phylogenomic databases
HOGENOM	HBG482701.
OMA	ETEILNA.
ProtClustDB	PRK09369.
Enzyme and pathway databases
BioCyc	LLAC272623:L134243-MONOMER.
Family and domain databases
HAMAP	MF_00111. MurA. [Tree]
InterPro	IPR001986. Enolpyruvate_Tfrase_dom. IPR013792. RNA3'P_cycl/enolpyr_Trfase_a/b. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
KO	K00790.
PANTHER	PTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
SUPFAM	SSF55205. RNA3'_cycl/enolpyr_transf_A/B. 1 hit.
TIGRFAMs	TIGR01072. MurA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA1_LACLA

Accession

Primary (citable) accession number: Q9CI17

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	January 25, 2012
This is version 83 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program