Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9CHU6

- 6PGD_LACLA

UniProt

Q9CHU6 - 6PGD_LACLA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

6-phosphogluconate dehydrogenase, decarboxylating

Gene

gnd

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO2, with concomitant reduction of NADP to NADPH.By similarity

Catalytic activityi

6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei102 – 1021NADPBy similarity
Binding sitei102 – 1021SubstrateBy similarity
Active sitei184 – 1841Proton acceptorBy similarity
Active sitei191 – 1911Proton donorBy similarity
Binding sitei192 – 1921SubstrateBy similarity
Binding sitei262 – 2621Substrate; via amide nitrogenBy similarity
Binding sitei289 – 2891SubstrateBy similarity
Binding sitei447 – 4471Substrate; shared with dimeric partnerBy similarity
Binding sitei453 – 4531Substrate; shared with dimeric partnerBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NADPBy similarity
Nucleotide bindingi33 – 353NADPBy similarity
Nucleotide bindingi74 – 763NADPBy similarity

GO - Molecular functioni

  1. NADP binding Source: InterPro
  2. phosphogluconate dehydrogenase (decarboxylating) activity Source: UniProtKB-EC

GO - Biological processi

  1. D-gluconate metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Gluconate utilization, Pentose shunt

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-680-MONOMER.
UniPathwayiUPA00115; UER00410.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconate dehydrogenase, decarboxylating (EC:1.1.1.44)
Gene namesi
Name:gnd
Ordered Locus Names:LL0622
ORF Names:L0046
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4724726-phosphogluconate dehydrogenase, decarboxylatingPRO_0000090045Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi272623.L0046.

Structurei

3D structure databases

ProteinModelPortaliQ9CHU6.
SMRiQ9CHU6. Positions 1-470.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni128 – 1303Substrate bindingBy similarity
Regioni187 – 1882Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0362.
HOGENOMiHOG000255147.
KOiK00033.
OMAiRVASENY.
OrthoDBiEOG6MSS4W.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view]
PIRSFiPIRSF000109. 6PGD. 1 hit.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00873. gnd. 1 hit.
PROSITEiPS00461. 6PGD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CHU6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQANFGVVG MAVMGKNLAL NVESRGYTVA IYNRTTSKTE EVYKEHQDKN
60 70 80 90 100
LVLTKTLEEF VGSLEKPRRI MLMVQAGAAT DATIKSLLPL LDKGDILIDG
110 120 130 140 150
GNTHFPDTMR RNAELADSGI NFIGTGVSGG EKGALLGPSM MPGGQKEAYD
160 170 180 190 200
LVAPIFEQIA AKAPQDGKPC VAYMGANGAG HYVKMVHNGI EYGDMQLIAE
210 220 230 240 250
SYDLLKRVLG LSNAEIQAIF EEWNEGELDS YLIEITKEVL KRKDDEGEGY
260 270 280 290 300
IVDKILDKAG NKGTGKWTSE SALDLGVPLP LITESVFARY ISTYKDERVK
310 320 330 340 350
ASKVLSGPAV NFSGDKKEVI EKIRKALYFS KIMSYAQGFA QLRKASEEFD
360 370 380 390 400
WDLPYGTIAQ IWRAGCIIRA EFLQNITDAF DKDSELENLL LDDYFVDITK
410 420 430 440 450
RYQEAVRDVV SLAVQAGIPI PTFTSAISYY DSYRSENLPA NLIQAQRDYF
460 470
GAHTYERTDK AGIFHYDWYT ED
Length:472
Mass (Da):52,424
Last modified:June 1, 2001 - v1
Checksum:i6EF4F504F217E55F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK04720.1.
PIRiF86702.
RefSeqiNP_266778.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK04720; AAK04720; L0046.
GeneIDi1114242.
KEGGilla:L0046.
PATRICi22293510. VBILacLac136773_0664.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK04720.1 .
PIRi F86702.
RefSeqi NP_266778.1. NC_002662.1.

3D structure databases

ProteinModelPortali Q9CHU6.
SMRi Q9CHU6. Positions 1-470.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L0046.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK04720 ; AAK04720 ; L0046 .
GeneIDi 1114242.
KEGGi lla:L0046.
PATRICi 22293510. VBILacLac136773_0664.

Phylogenomic databases

eggNOGi COG0362.
HOGENOMi HOG000255147.
KOi K00033.
OMAi RVASENY.
OrthoDBi EOG6MSS4W.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00410 .
BioCyci LLAC272623:GHSH-680-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
1.20.5.320. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR006114. 6PGDH_C.
IPR006113. 6PGDH_decarbox.
IPR006115. 6PGDH_NADP-bd.
IPR006184. 6PGdom_BS.
IPR013328. DH_multihelical.
IPR012284. Fibritin/6PGD_C-extension.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00393. 6PGD. 1 hit.
PF03446. NAD_binding_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF000109. 6PGD. 1 hit.
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00873. gnd. 1 hit.
PROSITEi PS00461. 6PGD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry namei6PGD_LACLA
AccessioniPrimary (citable) accession number: Q9CHU6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3