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Reviewed, UniProtKB/Swiss-Prot Q9CHL8 (LMRA_LACLA)

Last modified January 19, 2010. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Multidrug resistance ABC transporter ATP-binding and permease protein
    EC=3.6.3.44
Gene names
Name: lmrA
Ordered Locus Names: LL0711
ORF Names: L116532
OrganismLactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP]
Taxonomic identifier1360 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

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Protein attributes

Sequence length590 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Efflux transporter for a variety of amphiphilic cationic compounds, including antibiotics By similarity.

Catalytic activity

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subunit structure

Homodimer Potential.

Subcellular location

Cell membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the ABC transporter superfamily. Multidrug exporter lmrA (TC 3.A.1.117.1) family. [View classification]

Contains 1 ABC transmembrane type-1 domain.

Contains 1 ABC transporter domain.

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Ontologies

Keywords
   Biological processAntibiotic resistance
Transport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical term3D-structure
Complete proteome
Gene Ontology (GO)
   Biological processresponse to antibiotic

Inferred from electronic annotation. Source: UniProtKB-KW

transmembrane transport

Inferred from electronic annotation. Source: InterPro

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xenobiotic-transporting ATPase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 590590Multidrug resistance ABC transporter ATP-binding and permease protein
PRO_0000092413

Regions

Transmembrane35 – 5521 Potential
Transmembrane79 – 9921 Potential
Transmembrane150 – 17021 Potential
Transmembrane176 – 19621 Potential
Transmembrane261 – 28121 Potential
Transmembrane292 – 31221 Potential
Domain38 – 317280ABC transmembrane type-1
Domain349 – 584236ABC transporter
Nucleotide binding382 – 3898ATP Potential

Secondary structure

1 ................................................. 590
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
Q9CHL8-1 [UniParc].

Last modified July 25, 2003. Version 2.
Checksum: 8DF41419A01388CA

FASTA59064,698
        10         20         30         40         50         60 
MERGPQMANR IEGKAVDKTS IKHFIKLIRA AKPRYLFFII GILAGIVGTL IQLQVPKMVQ 

        70         80         90        100        110        120 
PLVNSFGHGV NGGKVALVIA LYIGSAAVSA IAAIVLGIFG ESVVKNLRTR VWDKMIHLPV 

       130        140        150        160        170        180 
KYFDEVKTGE MSSRLANDTT QVKNLIANSI PQAFTSILLL VGSIVFMLQM QWRLTLAMII 

       190        200        210        220        230        240 
AVPVVMLIMF PIMTFGQKIG RTRQDSLANF QGIASESLSE IRLVKSSNAE KQASKKAEND 

       250        260        270        280        290        300 
VNALYKIGVK EAIFDGLMSP VMMLSMMLMI FGLLAYGIYL ISTGVMSLGT LLGMMMYLMN 

       310        320        330        340        350        360 
LIGAVPTVAT FFTELAKASG STGRLTELLD EEQEVLHQGE SLDLEGKTLS ARHVDFAYDD 

       370        380        390        400        410        420 
SEQILRDISF EAQPNSIIAF AGPSGGGKST IFSLLERFYQ PTAGEITIDG QPIDNISLEN 

       430        440        450        460        470        480 
WRSQIGFVSQ DSAIMAGTIR ENLTYGLEGD YTDEDLWQVL DLAFARSFVE NMPDQLNTEV 

       490        500        510        520        530        540 
GERGVKISGG QRQRLAIARA FLRNPKILML DEATASLDSE SESMVQKALD SLMKGRTTLV 

       550        560        570        580        590 
IAHRLSTIVD ADKIYFIEKG QITGSGKHNE LVATHPLYAK YVSEQLTVGQ

« Hide

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References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005176 Genomic DNA. Translation: AAK04809.1. Different initiation.
PIRG86713.
RefSeqNP_266867.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1MV5X-ray3.10A/B/C/D349-584[»]
SMRQ9CHL8. Positions 21-585.
ModBaseSearch...

Genome annotation databases

GeneID1114336.
GenomeReviewsGene locus LL0711 in contig AE005176_GR.
KEGGlla:L116532.
NMPDRfig|272623.1.peg.729.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG758042.
OMANELVATH.

Enzyme and pathway databases

BioCycLLAC272623:L116532-MONOMER.
BRENDA3.6.3.44. 278870.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
[Graphical view]
PROSITEPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameLMRA_LACLA
AccessionPrimary (citable) accession number: Q9CHL8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: July 25, 2003
Last modified: January 19, 2010
This is version 75 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents