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Q9CHK3 (MENE_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
2-succinylbenzoate--CoA ligase
EC=6.2.1.26
Alternative name(s):
OSB-CoA synthetase
o-succinylbenzoyl-CoA synthetase
Gene names
Name:menE
Ordered Locus Names:LL0728
ORF Names:L0172
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length451 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). HAMAP MF_00731

Catalytic activity

ATP + 2-succinylbenzoate + CoA = AMP + diphosphate + 2-succinylbenzoyl-CoA. HAMAP MF_00731

Pathway

Cofactor biosynthesis; menaquinone biosynthesis; menaquinone-2 from chorismate: step 5/8. HAMAP MF_00731

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.

Sequence caution

The sequence AAK04826.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processMenaquinone biosynthesis
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processmenaquinone biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

o-succinylbenzoate-CoA ligase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 4514512-succinylbenzoate--CoA ligase HAMAP MF_00731
PRO_0000193161

Sequences

Sequence LengthMass (Da)Tools
Q9CHK3 [UniParc].

Last modified November 21, 2003. Version 2.
Checksum: D0F4EE4619182346

FASTA45150,578
        10         20         30         40         50         60 
MKWLKKQAEL YPQKQFLNDS TFAQINQEVN KMAEHLAPLI DNQSRVALLS ENSVEMAVVL 

        70         80         90        100        110        120 
FALLGLSKEV LLLNRHLTEY ELADQIKELK IDKVFTSDLL TEKVTDSISF SEIWTSNPCP 

       130        140        150        160        170        180 
VSLSADFPDE KIAVIMNTSA TTGKFKSVPI TWGMISNHVK ASKETLGAYD NDNWLVILPM 

       190        200        210        220        230        240 
FHVSGLSIIM RTLYNATSAT VVDKFDENQL LEMINSGKIN MVSLVPTLLT RIADKLHSNN 

       250        260        270        280        290        300 
LRLILLGGEF IPQPLIKKCQ ELGLPIYKTY GMTESFSQSV TFNILDFPDK TSSVGRPLPG 

       310        320        330        340        350        360 
VEIEIRQADL AGVGEIWLKS PMLMKAYLGQ KPYGTAFETG DIGYLDTDGF LYLLNRRKDI 

       370        380        390        400        410        420 
IISGGENIYP KEIEDLVYSL PEIKECALVA KPDAKWGQVP ILFVSGNISQ EKLENFLTEK 

       430        440        450 
LAKYKRPQSI TFMDELPKNA SGKILRKELK G

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005176 Genomic DNA. Translation: AAK04826.1. Different initiation.
PIRH86715.
RefSeqNP_266884.2. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CHK3.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1114354.
GenomeReviewsGene locus LL0728 in contig AE005176_GR.
KEGGlla:L0172.
NMPDRfig|272623.1.peg.747.
PATRIC22293748. VBILacLac136773_0781.

Phylogenomic databases

HOGENOMHBG547964.
OMAHIRESEF.
ProtClustDBCLSK643928.

Enzyme and pathway databases

BioCycLLAC272623:L0172-MONOMER.

Family and domain databases

HAMAPMF_00731. MenE.
[Tree]
InterProIPR000873. AMP-dep_Synth/Lig.
IPR010192. MenE.
IPR023015. SB_CoA_ligase_firmicutes.
[Graphical view]
KOK01911.
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
TIGRFAMsTIGR01923. MenE. 1 hit.
PROSITEPS00455. AMP_BINDING. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMENE_LACLA
AccessionPrimary (citable) accession number: Q9CHK3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 21, 2003
Last sequence update: November 21, 2003
Last modified: January 25, 2012
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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