Q9CHD5 (ARGC_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-acetyl-gamma-glutamyl-phosphate reductase
Short name=AGPR
EC=1.2.1.38

Alternative name(s):
N-acetyl-glutamate semialdehyde dehydrogenase
Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	LL0797
ORF Names:	L0104

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	340 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm Probable HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 340	340	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_0000112411
Sites
	Active site	147	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CHD5 [UniParc]. Last modified April 27, 2001. Version 1. Checksum: F0F001135CCC269C	FASTA	340	37,898
	10 20 30 40 50 60 MKKVAIVGIR GYSGLELFRI FYYHPEVEVT KIYATSHYGE KLSEHFPQLE GLTDLTISEF 70 80 90 100 110 120 NEEEIMAECD AVFFATSAGV SQKLALTFID NNFPVIDLSG DFRLADLEIY NKWYKNTNLK 130 140 150 160 170 180 NEYLLSGQYN LADIGQAKAN YIANPGCYAT ATLLALYPLV KNKMIDLDSI IVDAKSGLSG 190 200 210 220 230 240 AGKGLSDASH FVNVVDNMSM YKINSHQHIP EIAQQLKIWN SNFQALQFST SLIPVSRGIF 250 260 270 280 290 300 VSSYAKVAAD FDFETIKNAY EQVYATKNFV RIRRQMPHLS DVIGTNFCDI GLAYNPVTNV 310 320 330 340 LSVVSVIDNL MKGAAGQAVQ NFNQLFGYDE SLGLKFMPSL

References

[1]

"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK04895.1.
PIR	E86724.
RefSeq	NP_266953.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q9CHD5.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1114424.
GenomeReviews	Gene locus LL0797 in contig AE005176_GR.
KEGG	lla:L0104.
NMPDR	fig|272623.1.peg.817.
PATRIC	22293892. VBILacLac136773_0853.
Phylogenomic databases
HOGENOM	HBG294213.
OMA	VCRIAVH.
ProtClustDB	PRK00436.
Enzyme and pathway databases
BioCyc	LLAC272623:L0104-MONOMER.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR023013. AGPR_AS. IPR000706. AGPR_type-1. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
KO	K00145.
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. ArgC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_LACLA

Accession

Primary (citable) accession number: Q9CHD5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	January 25, 2012
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program