Q9CHD3 (ARGD_LACLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylornithine aminotransferase
Short name=ACOAT
EC=2.6.1.11

Gene names

Name:	argD
Ordered Locus Names:	LL0799
ORF Names:	L0106

Organism

Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)

Taxonomic identifier

272623 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	377 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate. HAMAP MF_01107
Cofactor	Binds 1 pyridoxal phosphate per subunit By similarity. HAMAP MF_01107
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4. HAMAP MF_01107
Subunit structure	Homodimer By similarity. HAMAP MF_01107
Subcellular location	Cytoplasm Probable HAMAP MF_01107.
Miscellaneous	May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. HAMAP MF_01107
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 377	377	Acetylornithine aminotransferase HAMAP MF_01107		PRO_0000112748
Regions
	Region	94 – 95	2	Pyridoxal phosphate binding By similarity
	Region	206 – 209	4	Pyridoxal phosphate binding By similarity
Sites
	Binding site	121	1	Pyridoxal phosphate; via carbonyl oxygen By similarity
	Binding site	124	1	N2-acetyl-L-ornithine By similarity
	Binding site	263	1	N2-acetyl-L-ornithine By similarity
	Binding site	264	1	Pyridoxal phosphate By similarity
Amino acid modifications
	Modified residue	235	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CHD3 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 1A139AF7A23ACC81	FASTA	377	41,328
	10 20 30 40 50 60 MTNLFENYGR LPFSLIKGED QYLFDDRGNK YLDFTSGIGV MNLGYSFEKG KVAVKAQLDS 70 80 90 100 110 120 LSHLSNLYQN PLQEDVAEKL SQNHSYKAFF CNSGTEANEA ALKLTHLIKK DQKILAFTDG 130 140 150 160 170 180 FHGRTFGAMS ATMQEKIQAG FSPLLPNFVA SPFNDVVALE QILEKEKIGA IIFEIIQGEG 190 200 210 220 230 240 GVLPISPDFV EALKSCQQKG ILLIIDEIQT GIGRTGKLFA FEHFDFEPDI FTLAKALANG 250 260 270 280 290 300 IPTGAMLAKN KYASYFSAGK HGSTFGGNPL AMASANEVLK EIDSDFLEKV TDKGIFFLKL 310 320 330 340 350 360 LTEKLSVKAT VKSIRGLGLM IGIQLTDEKK VPEVLALLRE NGLLALSAGH DVIRLLPPLV 370 MTKVELQKGA ELLEKIL

References

[1]	"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE005176 Genomic DNA. Translation: AAK04897.1.
PIR	G86724.
RefSeq	NP_266955.1. NC_002662.1.
3D structure databases
ProteinModelPortal	Q9CHD3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1114426.
GenomeReviews	Gene locus LL0799 in contig AE005176_GR.
KEGG	lla:L0106.
NMPDR	fig|272623.1.peg.819.
PATRIC	22293896. VBILacLac136773_0855.
Phylogenomic databases
HOGENOM	HBG725944.
OMA	GAMIGKA.
ProtClustDB	PRK02936.
Enzyme and pathway databases
BioCyc	LLAC272623:L0106-MONOMER.
Family and domain databases
HAMAP	MF_01107. ArgD_aminotrans_3. [Tree]
InterPro	IPR004636. AcOrn/SuccinylOrn_aminoTrfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 2 hits.
KO	K00818.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF19. ArgD_aminotrans. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00707. ArgD. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGD_LACLA

Accession

Primary (citable) accession number: Q9CHD3

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	June 1, 2001
Last modified:	January 25, 2012
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program