Reviewed, UniProtKB/Swiss-Prot Q9CHD1 (OTC_LACLA)

Names and origin

Protein names

Recommended name:
    Ornithine carbamoyltransferase
      Short name=OTCase
    EC=2.1.3.3

Gene names

Name:	argF
Ordered Locus Names:	LL0801
ORF Names:	L0108

Organism

Lactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP]

Taxonomic identifier

1360 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	333 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Carbamoyl phosphate + L-ornithine = phosphate + L-citrulline. HAMAP MF_01109
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 1/3. HAMAP MF_01109
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the ATCase/OTCase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	ornithine carbamoyltransferase complex Inferred from electronic annotation. Source: InterPro
Molecular function	amino acid binding Inferred from electronic annotation. Source: InterPro ornithine carbamoyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 333	333	Ornithine carbamoyltransferase HAMAP MF_01109		PRO_0000112933
Regions
	Region	54 – 58	5	Carbamoyl phosphate binding By similarity
	Region	267 – 270	4	Ornithine binding By similarity
Sites
	Binding site	105	1	Carbamoyl phosphate By similarity
	Binding site	132	1	Carbamoyl phosphate By similarity
	Site	29	1	Important for structural integrity By similarity
	Site	145	1	Important for structural integrity By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CHD1-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: B6CA3D7549C8B829	FASTA	333	37,822
	10 20 30 40 50 60 MFQGRSFLKE IDFSKDELLY LIDFAIHLKK LKKEHIQHKY LLDKNIALIF EKTSTRTRAA 70 80 90 100 110 120 FTTAAVDLGA HPEFLGPNDI QLGKKESISD TAKVLGSMFD GIEFRGFKQS DVEILAKDSG 130 140 150 160 170 180 RPVWNGLTDV WHPTQMLADF MTIKEHFGHL QDLTLAYVGD GRNNVANSLL VTGAILGVNI 190 200 210 220 230 240 TIISPESLQP ALEIQKLARK YAMKSRSKIS IRTDLNGLEN ADIVYTDVWV SMGEEAQTAK 250 260 270 280 290 300 RIKLLKSYQI NQKVVEKIIN KNFIFMHCLP SFHDLNTEVM KEIKENYNLN ELEVTDEVFN 310 320 330 SKNSVVFEQA ENRMHTIKEV MAATLGDLFI PKI

References

[1]

"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE005176 Genomic DNA. Translation: AAK04899.1.
PIR	A86725.
RefSeq	NP_266957.1.
3D structure databases
HSSP	HSSP built from PDB template 1AKM based on UniProtKB P04391.
ModBase	Search...
Genome annotation databases
GeneID	1114428.
GenomeReviews	Gene locus LL0801 in contig AE005176_GR.
KEGG	lla:L0108.
NMPDR	fig|272623.1.peg.821.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9CHD1.
OMA	FMTIKEH.
Enzyme and pathway databases
BioCyc	LLAC272623:L0108-MON.
BRENDA	2.1.3.3. 278870.
Family and domain databases
HAMAP	MF_01109. [Tree]
InterPro	IPR006132. Asp/Orn_carbamoyltranf_P_bd. IPR006130. Asp/Orn_carbamoylTrfase. IPR006131. Asp_carbamoyltransf_Asp/Orn_bd. IPR002292. Orn_carbamltrans. [Graphical view]
Pfam	PF00185. OTCace. 1 hit. PF02729. OTCace_N. 1 hit. [Graphical view]
PRINTS	PR00100. AOTCASE. PR00102. OTCASE.
TIGRFAMs	TIGR00658. orni_carb_tr. 1 hit.
PROSITE	PS00097. CARBAMOYLTRANSFERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

OTC_LACLA

Accession

Primary (citable) accession number: Q9CHD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
Last sequence update:	June 1, 2001
Last modified:	November 3, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)