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Q9CH07

- FTHS_LACLA

UniProt

Q9CH07 - FTHS_LACLA

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Protein
Formate--tetrahydrofolate ligase
Gene
fhs, LL0935, L159505
Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1005-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:LL0935
ORF Names:L159505
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 555555Formate--tetrahydrofolate ligaseUniRule annotation
PRO_0000199355Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272623.L159505.

Structurei

3D structure databases

ProteinModelPortaliQ9CH07.
SMRiQ9CH07. Positions 4-553.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CH07-1 [UniParc]FASTAAdd to Basket

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MKTDIEIAQA ADIQPITKIA EKIGLSFDDI ELYGKYKAKI PLEVLDKFDQ    50
QSEGKLVLVT SINPTPAGEG KSTVTVGLAD AFARQGKNVM VALREPSLGP 100
VMGIKGGAAG GGFAQVLPME DINLHFTGDI HAITTANNAI SAFLDNSLHQ 150
GNPLNIDPRR IIWKRVVDLN DRALRHVTVG LGGPLNGVPR EDGFDITVVS 200
EIMAVLCLAT SISDLKERLG KIVLAQSYDR KPVTLGDLGV QGAIAMLLKD 250
ALKPNLVQTI EGTPALIHGG PFANIAHGCN SVLATKTALK LSDIVITEAG 300
FGADLGGEKF LDIKTRQLGK QPDAVVIVAT LRALKMHGGL DKKELTKENV 350
EAVKKGFANL ERHIKNMQSY GLPVIVAINE FASDTKSEIS ALKDLTEALG 400
VPVSLTQVFA KGGEGGLDLA EKLSGMLQEK SDFSYLYDLK EPLSAKIDKV 450
VTEIYGGSKV NYSPKAKRQM REIEENGWND LPVCMAKTQY SFSDQPNLLA 500
APEGFEVTVR ELLPKIGAGF IVALLGDVMT MPGLPKNPAS LKMDVTDDGK 550
ISGLF 555
Length:555
Mass (Da):59,443
Last modified:June 1, 2001 - v1
Checksum:iBEF24F56C1B259A1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05033.1.
PIRiG86741.
RefSeqiNP_267091.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05033; AAK05033; L159505.
GeneIDi1114565.
KEGGilla:L159505.
PATRICi22294186. VBILacLac136773_1000.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05033.1 .
PIRi G86741.
RefSeqi NP_267091.1. NC_002662.1.

3D structure databases

ProteinModelPortali Q9CH07.
SMRi Q9CH07. Positions 4-553.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L159505.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK05033 ; AAK05033 ; L159505 .
GeneIDi 1114565.
KEGGi lla:L159505.
PATRICi 22294186. VBILacLac136773_1000.

Phylogenomic databases

eggNOGi COG2759.
HOGENOMi HOG000040280.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .
BioCyci LLAC272623:GHSH-1005-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiFTHS_LACLA
AccessioniPrimary (citable) accession number: Q9CH07
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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