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Q9CH07 (FTHS_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:LL0935
ORF Names:L159505
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199355

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CH07 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: BEF24F56C1B259A1

FASTA55559,443
        10         20         30         40         50         60 
MKTDIEIAQA ADIQPITKIA EKIGLSFDDI ELYGKYKAKI PLEVLDKFDQ QSEGKLVLVT 

        70         80         90        100        110        120 
SINPTPAGEG KSTVTVGLAD AFARQGKNVM VALREPSLGP VMGIKGGAAG GGFAQVLPME 

       130        140        150        160        170        180 
DINLHFTGDI HAITTANNAI SAFLDNSLHQ GNPLNIDPRR IIWKRVVDLN DRALRHVTVG 

       190        200        210        220        230        240 
LGGPLNGVPR EDGFDITVVS EIMAVLCLAT SISDLKERLG KIVLAQSYDR KPVTLGDLGV 

       250        260        270        280        290        300 
QGAIAMLLKD ALKPNLVQTI EGTPALIHGG PFANIAHGCN SVLATKTALK LSDIVITEAG 

       310        320        330        340        350        360 
FGADLGGEKF LDIKTRQLGK QPDAVVIVAT LRALKMHGGL DKKELTKENV EAVKKGFANL 

       370        380        390        400        410        420 
ERHIKNMQSY GLPVIVAINE FASDTKSEIS ALKDLTEALG VPVSLTQVFA KGGEGGLDLA 

       430        440        450        460        470        480 
EKLSGMLQEK SDFSYLYDLK EPLSAKIDKV VTEIYGGSKV NYSPKAKRQM REIEENGWND 

       490        500        510        520        530        540 
LPVCMAKTQY SFSDQPNLLA APEGFEVTVR ELLPKIGAGF IVALLGDVMT MPGLPKNPAS 

       550 
LKMDVTDDGK ISGLF 

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005176 Genomic DNA. Translation: AAK05033.1.
PIRG86741.
RefSeqNP_267091.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CH07.
SMRQ9CH07. Positions 4-553.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L159505.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK05033; AAK05033; L159505.
GeneID1114565.
KEGGlla:L159505.
PATRIC22294186. VBILacLac136773_1000.

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-1005-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_LACLA
AccessionPrimary (citable) accession number: Q9CH07
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways