Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei600For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciLLAC272623:G1FZA-1069-MONOMER

Protein family/group databases

MEROPSiC44.A08

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:LL1006
ORF Names:L33556
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001353432 – 605Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST604

Proteomic databases

PaxDbiQ9CGT6
PRIDEiQ9CGT6

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi272623.L33556

Structurei

3D structure databases

ProteinModelPortaliQ9CGT6
SMRiQ9CGT6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 219Glutamine amidotransferase type-2UniRule annotationAdd BLAST218
Domaini285 – 424SIS 1UniRule annotationAdd BLAST140
Domaini457 – 595SIS 2UniRule annotationAdd BLAST139

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46 Bacteria
COG0449 LUCA
HOGENOMiHOG000258896
KOiK00820
OMAiASEYRYA

Family and domain databases

CDDicd05008 SIS_GlmS_GlmD_1, 1 hit
cd05009 SIS_GlmS_GlmD_2, 1 hit
Gene3Di3.60.20.10, 1 hit
HAMAPiMF_00164 GlmS, 1 hit
InterProiView protein in InterPro
IPR017932 GATase_2_dom
IPR035466 GlmS/AgaS_SIS
IPR035490 GlmS/FrlB_SIS
IPR005855 GlmS_trans
IPR029055 Ntn_hydrolases_N
IPR001347 SIS
PANTHERiPTHR10937:SF0 PTHR10937:SF0, 1 hit
PfamiView protein in Pfam
PF01380 SIS, 2 hits
SUPFAMiSSF56235 SSF56235, 1 hit
TIGRFAMsiTIGR01135 glmS, 1 hit
PROSITEiView protein in PROSITE
PS51278 GATASE_TYPE_2, 1 hit
PS51464 SIS, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9CGT6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGVVGS KNATDILMQG LEKLEYRGYD SAGIFVNGQE TAAKLVKSVG
60 70 80 90 100
RIADLRGKLG IDVSGTAGIG HTRWATHGKP TEDNAHPHTS TSGRFILVHN
110 120 130 140 150
GVIENFVELK NEFLMNDTFK GQTDTEIAVH LIAKFAEEEG LSTLEAFKKA
160 170 180 190 200
LSLIQGSYAF ALMDSEDAEV IYVAKNKSPL LIGLGEGYNM VCSDAMAMIR
210 220 230 240 250
ETSEFMEIHD KELVVLTKDN VTVMDYEGNV LSRESYTAEL DLSDIGKGTY
260 270 280 290 300
PFYMLKEIDE QPAVMRKLIA TYANEDGTMK VDQDIIKGIQ EADRIYIIAA
310 320 330 340 350
GTSYHAGFGA KMMLESLTNT PVELGLASEW GYDMPLLSQK PFFIFLSQSG
360 370 380 390 400
ETADSRQVLV KVNELGLPSL TVTNVPGSTL SREATYTMLI GAGPEIAVAS
410 420 430 440 450
TKAYTGQIAT LAFLAKAVGE AEGEVKAKEF DLVKELSLVA QSIEATLSEK
460 470 480 490 500
DEIAAIVADL LPTTRNAFYI GRKQDYYVAM EASLKLKEIS YIQCEGFAAG
510 520 530 540 550
ELKHGTISLI EKGTPVLALI SNNEEVAAHT RGNVMETVAR GASAITIVEE
560 570 580 590 600
GVAREDDTIV VNQVHPYLSA ISMVIPTQLI AYYASMQRGL DVDKPRNLAK

AVTVE
Length:605
Mass (Da):65,612
Last modified:January 23, 2007 - v2
Checksum:iEAD4AA18C96E1785
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK05104.1
PIRiF86750
RefSeqiNP_267162.1, NC_002662.1
WP_010905678.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK05104; AAK05104; L33556
GeneIDi1114637
KEGGilla:L33556
PATRICifig|272623.7.peg.1076

Similar proteinsi

Entry informationi

Entry nameiGLMS_LACLA
AccessioniPrimary (citable) accession number: Q9CGT6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health