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Q9CGT6

- GLMS_LACLA

UniProt

Q9CGT6 - GLMS_LACLA

Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21Nucleophile; for GATase activityUniRule annotation
    Active sitei600 – 6001For Fru-6P isomerization activityUniRule annotation

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    BioCyciLLAC272623:GHSH-1077-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
    Alternative name(s):
    D-fructose-6-phosphate amidotransferaseUniRule annotation
    GFATUniRule annotation
    Glucosamine-6-phosphate synthaseUniRule annotation
    Hexosephosphate aminotransferaseUniRule annotation
    L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
    Gene namesi
    Name:glmSUniRule annotation
    Ordered Locus Names:LL1006
    ORF Names:L33556
    OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
    Taxonomic identifieri272623 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
    ProteomesiUP000002196: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedUniRule annotation
    Chaini2 – 605604Glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135343Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi272623.L33556.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9CGT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 219218Glutamine amidotransferase type-2UniRule annotationAdd
    BLAST
    Domaini285 – 424140SIS 1UniRule annotationAdd
    BLAST
    Domaini457 – 595139SIS 2UniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.UniRule annotation
    Contains 2 SIS domains.UniRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Phylogenomic databases

    eggNOGiCOG0449.
    HOGENOMiHOG000258896.
    KOiK00820.
    OMAiRIIICAC.
    OrthoDBiEOG6KT2Q1.

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    HAMAPiMF_00164. GlmS.
    InterProiIPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9CGT6-1 [UniParc]FASTAAdd to Basket

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    MCGIVGVVGS KNATDILMQG LEKLEYRGYD SAGIFVNGQE TAAKLVKSVG    50
    RIADLRGKLG IDVSGTAGIG HTRWATHGKP TEDNAHPHTS TSGRFILVHN 100
    GVIENFVELK NEFLMNDTFK GQTDTEIAVH LIAKFAEEEG LSTLEAFKKA 150
    LSLIQGSYAF ALMDSEDAEV IYVAKNKSPL LIGLGEGYNM VCSDAMAMIR 200
    ETSEFMEIHD KELVVLTKDN VTVMDYEGNV LSRESYTAEL DLSDIGKGTY 250
    PFYMLKEIDE QPAVMRKLIA TYANEDGTMK VDQDIIKGIQ EADRIYIIAA 300
    GTSYHAGFGA KMMLESLTNT PVELGLASEW GYDMPLLSQK PFFIFLSQSG 350
    ETADSRQVLV KVNELGLPSL TVTNVPGSTL SREATYTMLI GAGPEIAVAS 400
    TKAYTGQIAT LAFLAKAVGE AEGEVKAKEF DLVKELSLVA QSIEATLSEK 450
    DEIAAIVADL LPTTRNAFYI GRKQDYYVAM EASLKLKEIS YIQCEGFAAG 500
    ELKHGTISLI EKGTPVLALI SNNEEVAAHT RGNVMETVAR GASAITIVEE 550
    GVAREDDTIV VNQVHPYLSA ISMVIPTQLI AYYASMQRGL DVDKPRNLAK 600
    AVTVE 605
    Length:605
    Mass (Da):65,612
    Last modified:January 23, 2007 - v2
    Checksum:iEAD4AA18C96E1785
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK05104.1.
    PIRiF86750.
    RefSeqiNP_267162.1. NC_002662.1.

    Genome annotation databases

    EnsemblBacteriaiAAK05104; AAK05104; L33556.
    GeneIDi1114637.
    KEGGilla:L33556.
    PATRICi22294338. VBILacLac136773_1076.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE005176 Genomic DNA. Translation: AAK05104.1 .
    PIRi F86750.
    RefSeqi NP_267162.1. NC_002662.1.

    3D structure databases

    ProteinModelPortali Q9CGT6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 272623.L33556.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAK05104 ; AAK05104 ; L33556 .
    GeneIDi 1114637.
    KEGGi lla:L33556.
    PATRICi 22294338. VBILacLac136773_1076.

    Phylogenomic databases

    eggNOGi COG0449.
    HOGENOMi HOG000258896.
    KOi K00820.
    OMAi RIIICAC.
    OrthoDBi EOG6KT2Q1.

    Enzyme and pathway databases

    BioCyci LLAC272623:GHSH-1077-MONOMER.

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    HAMAPi MF_00164. GlmS.
    InterProi IPR017932. GATase_2_dom.
    IPR000583. GATase_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF00310. GATase_2. 1 hit.
    PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
      Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
      Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IL1403.

    Entry informationi

    Entry nameiGLMS_LACLA
    AccessioniPrimary (citable) accession number: Q9CGT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3