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Reviewed, UniProtKB/Swiss-Prot Q9CGM7 (PYRC_LACLA)

Last modified June 16, 2009. Version 48. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Dihydroorotase
      Short name=DHOase
    EC=3.5.2.3
Gene names
Name: pyrC
Ordered Locus Names: LL1069
ORF Names: L81189
OrganismLactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP]
Taxonomic identifier1360 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

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Protein attributes

Sequence length423 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

(S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate. HAMAP MF_00220

Cofactor

Binds 2 zinc ions per subunit By similarity.

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from HCO(3)(-): step 3/6. HAMAP MF_00220

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the DHOase family. Type 2 subfamily.

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Ontologies

Keywords
   Biological processPyrimidine biosynthesis
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processpyrimidine nucleotide biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Molecular functiondihydroorotase activity

Inferred from electronic annotation. Source: HAMAP

zinc ion binding

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 423423Dihydroorotase HAMAP MF_00220
PRO_0000147235

Sites

Metal binding601Zinc 1 By similarity
Metal binding621Zinc 1 By similarity
Metal binding1781Zinc 2 By similarity
Metal binding2311Zinc 2 By similarity
Metal binding3041Zinc 1 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9CGM7-1 [UniParc].

Last modified February 1, 2003. Version 2.
Checksum: 0A0A9CB6749E9B83

FASTA42345,676
        10         20         30         40         50         60 
MTLLIKNGRL VDPKSNRDEV LDILIENDKI VKIGLNLSVE NAEIVDARGL VVAPGLIDVH 

        70         80         90        100        110        120 
VHFREPGQTH KETIHSGAKS AAAGGFTRVV MMANTKPILS TPKVLTETLE IADKEDIKID 

       130        140        150        160        170        180 
AVGSITQDFD GEHLTDFDEL IKAGAIGFSD DGIPLTDAGV LRKALQKAKL TDSLISIHEE 

       190        200        210        220        230        240 
DPNLIGTLGV NDGEVAHKCG FTGAPTVSEY SMMARDSMIA YETGARLHIQ HLSAGESVEV 

       250        260        270        280        290        300 
VRFAKNLGAK ITAEVTPQHF SITEQMIFEQ GTNAKLNPPL RSTTDIGKII EGLKDGTIDV 

       310        320        330        340        350        360 
IATDHAPHTR EEKNVSLDKA PSGMIGLETS LQLGLTNLVA KGHLTLSELL TKMTVNPAKL 

       370        380        390        400        410        420 
YNFDAGYLAE NGPADLVIFD AENDYQVGET FDSKATNSPF IKQKVQGQVK YTICDGKIVY 


QAK

« Hide

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References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

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Cross-references

Sequence databases

AE006339 Genomic DNA. Translation: AAK05167.1. Different initiation.
PIRE86758.
RefSeqNP_267225.1.

3D structure databases

HSSPHSSP built from PDB template 1GKR based on UniProtKB P81006.
ModBaseSearch...

Genome annotation databases

GeneID1114709.
GenomeReviewsGene locus LL1069 in contig AE005176_GR.
KEGGlla:L81189.
NMPDRfig|272623.1.peg.1101.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ9CGM7.
OMAQ9CGM7. CDVHPVG.

Enzyme and pathway databases

BioCycLLAC272623:L81189-MON.
BRENDA3.5.2.3. 278870.

Family and domain databases

HAMAPMF_00220.
[Tree]
InterProIPR006680. Amidohydro_1.
IPR004722. DHOmult.
IPR002195. Dihydroorotase_CS.
[Graphical view]
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00857. pyrC_multi. 1 hit.
PROSITEPS00482. DIHYDROOROTASE_1. 1 hit.
PS00483. DIHYDROOROTASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry namePYRC_LACLA
AccessionPrimary (citable) accession number: Q9CGM7
Entry history
Integrated into UniProtKB/Swiss-Prot: February 1, 2003
Last sequence update: February 1, 2003
Last modified: June 16, 2009
This is version 48 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents