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Protein

L-lactate dehydrogenase 3

Gene

ldhX

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase 2 (ldhB), L-lactate dehydrogenase 3 (ldhX), L-lactate dehydrogenase 1 (ldhA)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95SubstrateUniRule annotation1
Binding sitei127NAD or substrateUniRule annotation1
Binding sitei158SubstrateUniRule annotation1
Active sitei182Proton acceptorUniRule annotation1
Binding sitei236SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi14 – 42NADUniRule annotationAdd BLAST29

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

SABIO-RKiQ9CGG8.
UniPathwayiUPA00554; UER00611.

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenase 3UniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDH 3UniRule annotation
Gene namesi
Name:ldhXUniRule annotation
Ordered Locus Names:LL1128
ORF Names:L142159
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001683531 – 323L-lactate dehydrogenase 3Add BLAST323

Proteomic databases

PaxDbiQ9CGG8.

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272623.L142159.

Structurei

3D structure databases

ProteinModelPortaliQ9CGG8.
SMRiQ9CGG8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C80. Bacteria.
COG0039. LUCA.
HOGENOMiHOG000213793.
KOiK00016.
OMAiSESCHGW.

Family and domain databases

Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00488. Lactate_dehydrog. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR011304. L-lactate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01771. L-LDH-NAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CGG8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKINNKKVVI VGAGAVGSTY AHNLVVDDLA DEIAIINTNK SKASANSLDL
60 70 80 90 100
LHALPYLNAA PKNIYAADYS DVSDADIVVL SANAPSATFG KNPDRLQLLE
110 120 130 140 150
NKVEMIRDIT RKTMDAGFDG IFLVASNPVD VLAQVVAEVS GLPKHRVIGT
160 170 180 190 200
GTLLETSRMR QIVAEKLQIN PKSIHGYVLA EHGKSSFAAW SNVTVGAIPL
210 220 230 240 250
TTWLKKYPNP EFPTFDEIDQ EIREVGLDIF MQKGNTSYGI AASLARLTRA
260 270 280 290 300
IFRNESVILP VSAYLTGEYG QFDLYTGSPA IIDRTGVRAV LELELTQEEQ
310 320
EKFKASTVLL KENFDSIKEK CTL
Length:323
Mass (Da):35,271
Last modified:June 1, 2001 - v1
Checksum:i87CCB4EA290A15DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK05226.1.
PIRiH86765.
RefSeqiNP_267284.1. NC_002662.1.
WP_010905773.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05226; AAK05226; L142159.
GeneIDi1114768.
KEGGilla:L142159.
PATRICifig|272623.7.peg.1206.

Similar proteinsi

Entry informationi

Entry nameiLDH3_LACLA
AccessioniPrimary (citable) accession number: Q9CGG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: June 1, 2001
Last modified: October 25, 2017
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families