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Q9CGE3 (FOLKE_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Bifunctional protein FolKE

Including the following 2 domains:

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
    EC=2.7.6.3
    Alternative name(s):
    6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
    Short name=PPPK
    7,8 dihydro-6-hydroxymethylpterin-pyrophosphokinase
    Short name=HPPK
  2. GTP cyclohydrolase 1
    EC=3.5.4.16
    Alternative name(s):
    GTP cyclohydrolase I
    Short name=GTP-CH-I
Gene names
Name:folKE
Ordered Locus Names:LL1154
ORF Names:L0175
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Lactococcus ›

Protein attributes

Sequence length349 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate. HAMAP-Rule MF_00223

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223

Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate: step 4/4. HAMAP-Rule MF_00223

Subunit structure

Homopolymer By similarity.

Sequence similarities

In the N-terminal section; belongs to the HPPK family.

In the C-terminal section; belongs to the GTP cyclohydrolase I family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 349349Bifunctional protein FolKE HAMAP-Rule MF_00223
PRO_0000119471

Regions

Region1 – 2262262-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HAMAP-Rule MF_00223
Region226 – 349124GTP cyclohydrolase 1 HAMAP-Rule MF_00223

Sequences

Sequence LengthMass (Da)Tools
Q9CGE3 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 143C36D2E84E2A88

FASTA34940,268
        10         20         30         40         50         60 
MQTTYLSMGS NIGDRQYYLH EAIRLLGKHP KIMIEKVSNF YESTPVGGVK QDDFTNLALK 

        70         80         90        100        110        120 
VATLLEPLEL LSFIHEVELS LNRERKIHWG PRTIDIDIIF YDDLEMQVEN LVIPHKEAFN 

       130        140        150        160        170        180 
RLFVLKPIFE LIDKDFKYYA SIEKAIAELS VSEQELHVIK EEKTPRNRIE DAVKEILFAV 

       190        200        210        220        230        240 
GENPNREGLL ETPARVAKMY EEILSSQRLS KFNEYKLFEI DSSKTDSIVL IKDIPFYSMC 

       250        260        270        280        290        300 
EHHMLPFFGK AHVAYIPADG KIIGLSKIPR LVDYVSRKLS VQENITHDIG DILTDILNPK 

       310        320        330        340 
GVAVLVEGRH MCVEMRGVKK VNSITKTSYF LGEFKENNEK RMEFLESLL

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005176 Genomic DNA. Translation: AAK05252.1.
PIRB86769.
RefSeqNP_267310.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CGE3.
ModBaseSearch...

Protein-protein interaction databases

STRING272623.L0175.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK05252; AAK05252; L0175.
GeneID1114796.
KEGGlla:L0175.
PATRIC22294652. VBILacLac136773_1234.

Phylogenomic databases

eggNOGCOG0801.
HOGENOMHOG000022731.
KOK00950.
K01495.
OMAFIHEVEL.
ProtClustDBCLSK876844.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-1277-MONOMER.
UniPathwayUPA00077; UER00155.
UPA00848; UER00151.

Family and domain databases

Gene3D3.30.70.560. 1 hit.
HAMAPMF_00223. FolE. Fused.
InterProIPR001474. GTP_CycHdrlase_I.
IPR020602. GTP_CycHdrlase_I/CN_OxRdtase.
IPR018234. GTP_CycHdrlase_I_CS.
IPR000550. Hppk.
[Graphical view]
PANTHERPTHR11109. PTHR11109. 1 hit.
PfamPF01227. GTP_cyclohydroI. 1 hit.
PF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMSSF55083. Hppk. 1 hit.
TIGRFAMsTIGR00063. folE. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. False negative.
PS00794. HPPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFOLKE_LACLA
AccessionPrimary (citable) accession number: Q9CGE3
Entry history
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: May 1, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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