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Q9CGE3

- FOLKE_LACLA

UniProt

Q9CGE3 - FOLKE_LACLA

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Protein

Bifunctional protein FolKE

Gene

folKE

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi

GO - Molecular functioni

  1. 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity Source: UniProtKB-EC
  2. ATP binding Source: UniProtKB-KW
  3. GTP binding Source: UniProtKB-KW
  4. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP
  5. kinase activity Source: UniProtKB-KW
  6. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. folic acid biosynthetic process Source: UniProtKB-KW
  3. one-carbon metabolic process Source: UniProtKB-HAMAP
  4. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Kinase, Transferase

Keywords - Biological processi

Folate biosynthesis, One-carbon metabolism

Keywords - Ligandi

ATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1236-MONOMER.
UniPathwayiUPA00077; UER00155.
UPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein FolKE
Including the following 2 domains:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8 dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folKE
Ordered Locus Names:LL1154
ORF Names:L0175
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 349349Bifunctional protein FolKEPRO_0000119471Add
BLAST

Interactioni

Subunit structurei

Homopolymer.By similarity

Protein-protein interaction databases

STRINGi272623.L0175.

Structurei

3D structure databases

ProteinModelPortaliQ9CGE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2262262-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseAdd
BLAST
Regioni226 – 349124GTP cyclohydrolase 1Add
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the HPPK family.Curated
In the C-terminal section; belongs to the GTP cyclohydrolase I family.Curated

Phylogenomic databases

eggNOGiCOG0801.
HOGENOMiHOG000022731.
KOiK00950.
K01495.
OMAiFIHEVEL.
OrthoDBiEOG6XHC8G.

Family and domain databases

Gene3Di3.30.70.560. 1 hit.
HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
IPR000550. Hppk.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
PF01288. HPPK. 1 hit.
[Graphical view]
SUPFAMiSSF55083. SSF55083. 1 hit.
TIGRFAMsiTIGR00063. folE. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00794. HPPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9CGE3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQTTYLSMGS NIGDRQYYLH EAIRLLGKHP KIMIEKVSNF YESTPVGGVK
60 70 80 90 100
QDDFTNLALK VATLLEPLEL LSFIHEVELS LNRERKIHWG PRTIDIDIIF
110 120 130 140 150
YDDLEMQVEN LVIPHKEAFN RLFVLKPIFE LIDKDFKYYA SIEKAIAELS
160 170 180 190 200
VSEQELHVIK EEKTPRNRIE DAVKEILFAV GENPNREGLL ETPARVAKMY
210 220 230 240 250
EEILSSQRLS KFNEYKLFEI DSSKTDSIVL IKDIPFYSMC EHHMLPFFGK
260 270 280 290 300
AHVAYIPADG KIIGLSKIPR LVDYVSRKLS VQENITHDIG DILTDILNPK
310 320 330 340
GVAVLVEGRH MCVEMRGVKK VNSITKTSYF LGEFKENNEK RMEFLESLL
Length:349
Mass (Da):40,268
Last modified:June 1, 2001 - v1
Checksum:i143C36D2E84E2A88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK05252.1.
PIRiB86769.
RefSeqiNP_267310.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05252; AAK05252; L0175.
GeneIDi1114796.
KEGGilla:L0175.
PATRICi22294652. VBILacLac136773_1234.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA. Translation: AAK05252.1 .
PIRi B86769.
RefSeqi NP_267310.1. NC_002662.1.

3D structure databases

ProteinModelPortali Q9CGE3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L0175.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK05252 ; AAK05252 ; L0175 .
GeneIDi 1114796.
KEGGi lla:L0175.
PATRICi 22294652. VBILacLac136773_1234.

Phylogenomic databases

eggNOGi COG0801.
HOGENOMi HOG000022731.
KOi K00950.
K01495.
OMAi FIHEVEL.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00077 ; UER00155 .
UPA00848 ; UER00151 .
BioCyci LLAC272623:GHSH-1236-MONOMER.

Family and domain databases

Gene3Di 3.30.70.560. 1 hit.
HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
IPR000550. Hppk.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
PF01288. HPPK. 1 hit.
[Graphical view ]
SUPFAMi SSF55083. SSF55083. 1 hit.
TIGRFAMsi TIGR00063. folE. 1 hit.
TIGR01498. folK. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00794. HPPK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiFOLKE_LACLA
AccessioniPrimary (citable) accession number: Q9CGE3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: October 1, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3