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Protein

Bifunctional protein FolKE

Gene

folKE

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 6-hydroxymethyl-7,8-dihydropterin = AMP + 6-hydroxymethyl-7,8-dihydropterin diphosphate.
GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.
Proteins known to be involved in this subpathway in this organism are:
  1. Bifunctional protein FolKE (folKE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Pathwayi: tetrahydrofolate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Probable DHNTP pyrophosphohydrolase (folQ)
  2. no protein annotated in this organism
  3. 7,8-dihydroneopterin aldolase (folB)
  4. Bifunctional protein FolKE (folKE)
This subpathway is part of the pathway tetrahydrofolate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8-dihydroneopterin triphosphate, the pathway tetrahydrofolate biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Kinase, Multifunctional enzyme, Transferase
Biological processFolate biosynthesis, One-carbon metabolism
LigandATP-binding, GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLLAC272623:G1FZA-1225-MONOMER
UniPathwayiUPA00077; UER00155
UPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein FolKE
Including the following 2 domains:
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase (EC:2.7.6.3)
Alternative name(s):
6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Short name:
PPPK
7,8 dihydro-6-hydroxymethylpterin-pyrophosphokinase
Short name:
HPPK
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folKE
Ordered Locus Names:LL1154
ORF Names:L0175
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
Proteomesi
  • UP000002196 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001194711 – 349Bifunctional protein FolKEAdd BLAST349

Proteomic databases

PaxDbiQ9CGE3

Interactioni

Subunit structurei

Homopolymer.By similarity

Protein-protein interaction databases

STRINGi272623.L0175

Structurei

3D structure databases

ProteinModelPortaliQ9CGE3
SMRiQ9CGE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 2262-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinaseAdd BLAST226
Regioni226 – 349GTP cyclohydrolase 1Add BLAST124

Sequence similaritiesi

In the N-terminal section; belongs to the HPPK family.Curated
In the C-terminal section; belongs to the GTP cyclohydrolase I family.Curated

Phylogenomic databases

eggNOGiENOG4105EUJ Bacteria
COG0302 LUCA
COG0801 LUCA
HOGENOMiHOG000022731
KOiK00950
K01495
OMAiHPEAFNR

Family and domain databases

CDDicd00483 HPPK, 1 hit
Gene3Di3.30.70.5601 hit
HAMAPiMF_00223 FolE, 1 hit
InterProiView protein in InterPro
IPR001474 GTP_CycHdrlase_I
IPR018234 GTP_CycHdrlase_I_CS
IPR020602 GTP_CycHdrlase_I_dom
IPR000550 Hppk
IPR035907 Hppk_sf
PANTHERiPTHR11109 PTHR11109, 1 hit
PfamiView protein in Pfam
PF01227 GTP_cyclohydroI, 1 hit
PF01288 HPPK, 1 hit
SUPFAMiSSF55083 SSF55083, 1 hit
TIGRFAMsiTIGR00063 folE, 1 hit
TIGR01498 folK, 1 hit
PROSITEiView protein in PROSITE
PS00859 GTP_CYCLOHYDROL_1_1, 1 hit
PS00794 HPPK, 1 hit

Sequencei

Sequence statusi: Complete.

Q9CGE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTTYLSMGS NIGDRQYYLH EAIRLLGKHP KIMIEKVSNF YESTPVGGVK
60 70 80 90 100
QDDFTNLALK VATLLEPLEL LSFIHEVELS LNRERKIHWG PRTIDIDIIF
110 120 130 140 150
YDDLEMQVEN LVIPHKEAFN RLFVLKPIFE LIDKDFKYYA SIEKAIAELS
160 170 180 190 200
VSEQELHVIK EEKTPRNRIE DAVKEILFAV GENPNREGLL ETPARVAKMY
210 220 230 240 250
EEILSSQRLS KFNEYKLFEI DSSKTDSIVL IKDIPFYSMC EHHMLPFFGK
260 270 280 290 300
AHVAYIPADG KIIGLSKIPR LVDYVSRKLS VQENITHDIG DILTDILNPK
310 320 330 340
GVAVLVEGRH MCVEMRGVKK VNSITKTSYF LGEFKENNEK RMEFLESLL
Length:349
Mass (Da):40,268
Last modified:June 1, 2001 - v1
Checksum:i143C36D2E84E2A88
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE005176 Genomic DNA Translation: AAK05252.1
PIRiB86769
RefSeqiNP_267310.1, NC_002662.1
WP_010905789.1, NC_002662.1

Genome annotation databases

EnsemblBacteriaiAAK05252; AAK05252; L0175
GeneIDi1114796
KEGGilla:L0175
PATRICifig|272623.7.peg.1234

Similar proteinsi

Entry informationi

Entry nameiFOLKE_LACLA
AccessioniPrimary (citable) accession number: Q9CGE3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 1, 2001
Last modified: February 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome