Reviewed, UniProtKB/Swiss-Prot Q9CGD8 (DHOM_LACLA)

Names and origin

Protein names

Recommended name:
    Homoserine dehydrogenase
      Short name=HDH
    EC=1.1.1.3

Gene names

Name:	hom
Ordered Locus Names:	LL1159
ORF Names:	L0090

Organism

Lactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP]

Taxonomic identifier

1360 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	428 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	L-homoserine + NAD(P)+ = L-aspartate 4-semialdehyde + NAD(P)H.
Pathway	Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-homoserine from L-aspartate: step 3/3. Amino-acid biosynthesis; L-threonine biosynthesis; L-threonine from L-aspartate: step 3/5.
Sequence similarities	Belongs to the homoserine dehydrogenase family. Contains 1 ACT domain.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Branched-chain amino acid biosynthesis Isoleucine biosynthesis Methionine biosynthesis Threonine biosynthesis
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	isoleucine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW methionine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW threonine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	NADP or NADPH binding Inferred from electronic annotation. Source: InterPro amino acid binding Inferred from electronic annotation. Source: InterPro homoserine dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 428	428	Homoserine dehydrogenase		PRO_0000066696
Regions
	Domain	350 – 423	74	ACT
	Nucleotide binding	8 – 15	8	NADP By similarity
Sites
	Active site	206	1	Proton donor Potential
	Binding site	106	1	NADP By similarity
	Binding site	191	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9CGD8-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: B99C159FB1BEF21C	FASTA	428	46,921
	10 20 30 40 50 60 MTVNIAILGF GTVGTGLPTL ISENKEKLSK ILDEEIVISK VLMRDEKAIE KARAQGYQYD 70 80 90 100 110 120 FVLTLEEILA DSEISIVVEL MGRIEPAKTY ITKVIKAGKN VVTANKDLLA VHGTELRALA 130 140 150 160 170 180 EKHHVALYYE AAVAGGIPIL RTLANSFSSD KITHLLGILN GTSNFMMTKM SEEAWTYDQS 190 200 210 220 230 240 LAKAQELGYA ESDPTNDVDG IDASYKLAIL SEFAFGMTLS PDQISKSGLR TIQKTDVEIA 250 260 270 280 290 300 QQFGYVLKLT GEINEVESGI FAEVSPTFLP KSHPLASVNG VMNAVFIESD GIGDSMFYGA 310 320 330 340 350 360 GAGQKPTATS VLADIVRIVK REKDGTIGKS FNEYARPTSL ANPHDIVNKY YFSVETPDST 370 380 390 400 410 420 GQLLRLVELF TSEDVSFEQV LQQKGDGHRA VVVIISHQIN RVQLLAIQDK LKEEVDFKLL NYFKVLGD

References

[1]

"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006348 Genomic DNA. Translation: AAK05257.1.
PIR	G86769.
RefSeq	NP_267315.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1114801.
GenomeReviews	Gene locus LL1159 in contig AE005176_GR.
KEGG	lla:L0090.
NMPDR	fig|272623.1.peg.1193.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9CGD8.
OMA	Q9CGD8. NVEGIDN.
Enzyme and pathway databases
BioCyc	LLAC272623:L0090-MON.
BRENDA	1.1.1.3. 278870.
Family and domain databases
InterPro	IPR002912. ACT_bd. IPR005106. Asp/hSer_DH_NAD-bd. IPR016204. Homoserine_dehydrogenase. IPR001342. Homoserine_dehydrogenase_cat. IPR019811. Homoserine_dehydrogenase_CS. [Graphical view]
Pfam	PF01842. ACT. 1 hit. PF00742. Homoserine_dh. 1 hit. PF03447. NAD_binding_3. 1 hit. [Graphical view]
PIRSF	PIRSF000098. Homoser_dehydrog. 1 hit.
PROSITE	PS01042. HOMOSER_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DHOM_LACLA

Accession

Primary (citable) accession number: Q9CGD8

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)