ID   CEO1_LACLA              Reviewed;         309 AA.
AC   Q9CG73;
DT   27-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   16-JUN-2009, entry version 46.
DE   RecName: Full=N(5)-(carboxyethyl)ornithine synthase;
DE            EC=1.5.1.24;
DE   AltName: Full=N(5)-(L-1-carboxyethyl)-L-ornithine:NADP(+) oxidoreductase;
DE            Short=CEOS;
GN   Name=ceo; OrderedLocusNames=LL1237; ORFNames=L64332;
OS   Lactococcus lactis subsp. lactis (Streptococcus lactis).
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae; Lactococcus.
OX   NCBI_TaxID=1360;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IL1403;
RX   MEDLINE=21235186; PubMed=11337471; DOI=10.1101/gr.GR-1697R;
RA   Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K.,
RA   Weissenbach J., Ehrlich S.D., Sorokin A.;
RT   "The complete genome sequence of the lactic acid bacterium Lactococcus
RT   lactis ssp. lactis IL1403.";
RL   Genome Res. 11:731-753(2001).
CC   -!- CATALYTIC ACTIVITY: N(5)-(L-1-carboxyethyl)-L-ornithine + NADP(+)
CC       + H(2)O = L-ornithine + pyruvate + NADPH.
CC   -!- SUBUNIT: Homotetramer (By similarity).
CC   -!- MISCELLANEOUS: In the reverse direction L-lysine can act instead
CC       of L-ornithine, more slowly, yielding N(6)-(L-1-carboxyethyl)-L-
CC       lysine (By similarity).
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AE006356; AAK05335.1; -; Genomic_DNA.
DR   PIR; E86779; E86779.
DR   RefSeq; NP_267393.1; -.
DR   GeneID; 1114886; -.
DR   GenomeReviews; AE005176_GR; LL1237.
DR   KEGG; lla:L64332; -.
DR   NMPDR; fig|272623.1.peg.1272; -.
DR   HOGENOM; Q9CG73; -.
DR   OMA; Q9CG73; NTIEGTH.
DR   BioCyc; LLAC272623:L64332-MON; -.
DR   BRENDA; 1.5.1.24; 278870.
DR   GO; GO:0005488; F:binding; IEA:InterPro.
DR   GO; GO:0009055; F:electron carrier activity; IEA:InterPro.
DR   GO; GO:0047126; F:N5-(carboxyethyl)ornithine synthase activity; IEA:EC.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   InterPro; IPR007698; Ala_DH/PNT_C.
DR   InterPro; IPR007886; Ala_DH/PNT_N.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   Pfam; PF05222; AlaDh_PNT_N; 1.
PE   3: Inferred from homology;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    309       N(5)-(carboxyethyl)ornithine synthase.
FT                                /FTId=PRO_0000089482.
FT   NP_BIND     171    176       NADP (Potential).
SQ   SEQUENCE   309 AA;  35008 MW;  51C5E5ED8DE508FA CRC64;
     MKIGLVKTNF PGERRVPLLP KDIKDFKNEI LVEEGFGKFL DIDDQEYIDK GCHILSRAEV
     FSESEAIFSL KLIQPTDYPY LREGQMIIGW THPFGSGRLF MKEQALPKKL IVVDLDSNSP
     CIYYENEIFE SGIPKGLLYK NSFYAGYAGV LDALLQYGFI PTEETKIAIL GSGNVAQGAF
     SSISKYSSNI RMYYRKTMSI FKENYTKYDI IINGIEIGKE DDPILSFSEQ KSLKKGTFII
     DVAADAGNTI EGTHFTSMDD PIYENDGKYY YVVPNTPSLI YRNVSQDLSK ILSENIFSED
     CSRFLSIKS
//