Reviewed, UniProtKB/Swiss-Prot Q9CG73 (CEO1_LACLA)

Names and origin

Protein names

Recommended name:
    N(5)-(carboxyethyl)ornithine synthase
    EC=1.5.1.24
Alternative name(s):
    N(5)-(L-1-carboxyethyl)-L-ornithine:NADP(+) oxidoreductase
      Short name=CEOS

Gene names

Name:	ceo
Ordered Locus Names:	LL1237
ORF Names:	L64332

Organism

Lactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP]

Taxonomic identifier

1360 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

Protein attributes

Sequence length	309 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N(5)-(L-1-carboxyethyl)-L-ornithine + NADP+ + H2O = L-ornithine + pyruvate + NADPH.
Subunit structure	Homotetramer By similarity.
Miscellaneous	In the reverse direction L-lysine can act instead of L-ornithine, more slowly, yielding N(6)-(L-1-carboxyethyl)-L-lysine By similarity.

Ontologies

Keywords
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	N5-(carboxyethyl)ornithine synthase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro electron carrier activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 309	309	N(5)-(carboxyethyl)ornithine synthase		PRO_0000089482
Regions
	Nucleotide binding	171 – 176	6	NADP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9CG73-1 [UniParc]. Last modified June 1, 2001. Version 1. Checksum: 51C5E5ED8DE508FA	FASTA	309	35,008
	10 20 30 40 50 60 MKIGLVKTNF PGERRVPLLP KDIKDFKNEI LVEEGFGKFL DIDDQEYIDK GCHILSRAEV 70 80 90 100 110 120 FSESEAIFSL KLIQPTDYPY LREGQMIIGW THPFGSGRLF MKEQALPKKL IVVDLDSNSP 130 140 150 160 170 180 CIYYENEIFE SGIPKGLLYK NSFYAGYAGV LDALLQYGFI PTEETKIAIL GSGNVAQGAF 190 200 210 220 230 240 SSISKYSSNI RMYYRKTMSI FKENYTKYDI IINGIEIGKE DDPILSFSEQ KSLKKGTFII 250 260 270 280 290 300 DVAADAGNTI EGTHFTSMDD PIYENDGKYY YVVPNTPSLI YRNVSQDLSK ILSENIFSED CSRFLSIKS

References

[1]

"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403." Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A. Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: IL1403.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE006356 Genomic DNA. Translation: AAK05335.1.
PIR	E86779.
RefSeq	NP_267393.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1114886.
GenomeReviews	Gene locus LL1237 in contig AE005176_GR.
KEGG	lla:L64332.
NMPDR	fig|272623.1.peg.1272.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q9CG73.
OMA	Q9CG73. NTIEGTH.
Enzyme and pathway databases
BioCyc	LLAC272623:L64332-MON.
BRENDA	1.5.1.24. 278870.
Family and domain databases
InterPro	IPR007698. Ala_DH/PNT_C. IPR007886. Ala_DH/PNT_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01262. AlaDh_PNT_C. 1 hit. PF05222. AlaDh_PNT_N. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CEO1_LACLA

Accession

Primary (citable) accession number: Q9CG73

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	June 1, 2001
Last modified:	June 16, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)