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Q9CG20

- DCE_LACLA

UniProt

Q9CG20 - DCE_LACLA

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Protein

Glutamate decarboxylase

Gene
gadB, LL1290, L123581
Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Converts internalized glutamate to GABA and increases the internal pH. Involved in glutamate-dependent acid resistance By similarity.

Catalytic activityi

L-glutamate = 4-aminobutanoate + CO2.

Cofactori

Pyridoxal phosphate By similarity.

pH dependencei

Optimum pH is 4.7. Active at acidic pHs but inactive in the neutral pH range.

Temperature dependencei

Active up to 70 degrees Celsius at pH 4.1.

GO - Molecular functioni

  1. glutamate decarboxylase activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glutamate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1378-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate decarboxylase (EC:4.1.1.15)
Short name:
GAD
Gene namesi
Name:gadB
Ordered Locus Names:LL1290
ORF Names:L123581
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 466466Glutamate decarboxylasePRO_0000146986Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei277 – 2771N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi272623.L123581.

Structurei

3D structure databases

ProteinModelPortaliQ9CG20.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0076.
HOGENOMiHOG000070228.
KOiK01580.
OMAiPTFQINF.
OrthoDBiEOG6TFCPW.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
InterProiIPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11999:SF1. PTHR11999:SF1. 1 hit.
PfamiPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01788. Glu-decarb-GAD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CG20-1 [UniParc]FASTAAdd to Basket

« Hide

MLYGKENRDE AEFLEPIFGS ESEQVDLPKY KLAQQSIEPR VAYQLVQDEM    50
LDEGNARLNL ATFCQTYMEP EAVKLMSQTL EKNAIDKSEY PRTTEIENRC 100
VNMIADLWNA SEKEKFMGTS TIGSSEACML GGMAMKFSWR KRAEKLGLDI 150
NAKKPNLVIS SGYQVCWEKF CIYWDIEMRE VPMDKEHMSI NLDKVMDYVD 200
EYTIGVVGIM GITYTGRYDD IKALDNLIEE YNKQTDYKVY IHVDAASGGL 250
YAPFVEPELE WDFRLKNVIS INTSGHKYGL VYPGVGWVLW RDKKYLPEEL 300
IFKVSYLGGE LPTMAINFSH SASQLIGQYY NFVRYGFDGY KAIHERTHKV 350
AMFLAKEIEK TGMFEIMNDG SQLPIVCYKL KEDSNRGWNL YDLADRLLMK 400
GWQVPAYPLP KNLENEIIQR LVIRADFGMN MAFNYVQDMQ EAIEALNKAH 450
ILYHEEPENK TYGFTH 466
Length:466
Mass (Da):53,927
Last modified:June 1, 2001 - v1
Checksum:iBCDC732253E473C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010789 Genomic DNA. Translation: BAA24585.1.
AE005176 Genomic DNA. Translation: AAK05388.1.
PIRiB86786.
RefSeqiNP_267446.1. NC_002662.1.
WP_010905870.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05388; AAK05388; L123581.
GeneIDi1114939.
KEGGilla:L123581.
PATRICi22294970. VBILacLac136773_1393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB010789 Genomic DNA. Translation: BAA24585.1 .
AE005176 Genomic DNA. Translation: AAK05388.1 .
PIRi B86786.
RefSeqi NP_267446.1. NC_002662.1.
WP_010905870.1. NC_002662.1.

3D structure databases

ProteinModelPortali Q9CG20.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L123581.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK05388 ; AAK05388 ; L123581 .
GeneIDi 1114939.
KEGGi lla:L123581.
PATRICi 22294970. VBILacLac136773_1393.

Phylogenomic databases

eggNOGi COG0076.
HOGENOMi HOG000070228.
KOi K01580.
OMAi PTFQINF.
OrthoDBi EOG6TFCPW.

Enzyme and pathway databases

BioCyci LLAC272623:GHSH-1378-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
InterProi IPR010107. Glutamate_decarboxylase.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11999:SF1. PTHR11999:SF1. 1 hit.
Pfami PF00282. Pyridoxal_deC. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01788. Glu-decarb-GAD. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Lactococcus lactis contains only one glutamate decarboxylase gene."
    Nomura M., Nakajima I., Fujita Y., Kobayashi M., Kimoto H., Suzuki I., Aso H.
    Microbiology 145:1375-1380(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-15, CHARACTERIZATION.
    Strain: 01-7.
  2. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiDCE_LACLA
AccessioniPrimary (citable) accession number: Q9CG20
Secondary accession number(s): O50645
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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