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Q9CFY8

- PANE_LACLA

UniProt

Q9CFY8 - PANE_LACLA

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Protein

Putative 2-dehydropantoate 2-reductase

Gene

LL1323

Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.By similarity

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051NADP; via amide nitrogenBy similarity
Binding sitei105 – 1051SubstrateBy similarity
Active sitei187 – 1871Proton donorBy similarity
Binding sitei191 – 1911SubstrateBy similarity
Binding sitei195 – 1951SubstrateBy similarity
Binding sitei260 – 2601SubstrateBy similarity
Binding sitei273 – 2731NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADPBy similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1411-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:LL1323
ORF Names:L157055
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Putative 2-dehydropantoate 2-reductasePRO_0000157313Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272623.L157055.

Structurei

3D structure databases

ProteinModelPortaliQ9CFY8.
SMRiQ9CFY8. Positions 1-312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiMGLEPML.
OrthoDBiEOG6P5ZHG.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CFY8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRITIAGAGA MGSRFGLMLH KGGNEVTLID GWPEHVKAIK EHGLRANYNG
60 70 80 90 100
EELTAHLSVE LQSEISSKEK TDLIILFTKA MQLDKMLQDI KPLIDEHTKV
110 120 130 140 150
LCLLNGIGHE DTIEKYVSKN NIFIGNTMWT AGLEGPGKAK LFGDGSVELQ
160 170 180 190 200
NLISGEEETA KKLAEILSES GLNAKYSNNI HYSIYRKACV NGTMNGLCTI
210 220 230 240 250
LDTNMAGLGE TKPAHDMVVT IVNEFAAVAK FENVNLDIAE VVQHVETCFD
260 270 280 290 300
PSTIGLHYPS MYQDLIKNNR LTEIDYINGA VSRKGKKYNV ATPYCDFLTQ
310
LVHSKEELLK AK
Length:312
Mass (Da):34,444
Last modified:June 1, 2001 - v1
Checksum:i1C7FC4547F081BAD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05421.1.
PIRiC86790.
RefSeqiNP_267479.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05421; AAK05421; L157055.
GeneIDi1114972.
KEGGilla:L157055.
PATRICi22295038. VBILacLac136773_1427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05421.1 .
PIRi C86790.
RefSeqi NP_267479.1. NC_002662.1.

3D structure databases

ProteinModelPortali Q9CFY8.
SMRi Q9CFY8. Positions 1-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L157055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK05421 ; AAK05421 ; L157055 .
GeneIDi 1114972.
KEGGi lla:L157055.
PATRICi 22295038. VBILacLac136773_1427.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050222.
KOi K00077.
OMAi MGLEPML.
OrthoDBi EOG6P5ZHG.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .
BioCyci LLAC272623:GHSH-1411-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiPANE_LACLA
AccessioniPrimary (citable) accession number: Q9CFY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: June 1, 2001
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3