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Reviewed, UniProtKB/Swiss-Prot Q9CFY8 (PANE_LACLA)

Last modified February 9, 2010. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Putative 2-dehydropantoate 2-reductase
    EC=1.1.1.169
Alternative name(s):
    Ketopantoate reductase
      Short name=KPA reductase
      Short name=KPR
Gene names
Ordered Locus Names: LL1323
ORF Names: L157055
OrganismLactococcus lactis subsp. lactis (Streptococcus lactis) [Complete proteome] [HAMAP]
Taxonomic identifier1360 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Streptococcaceae › Lactococcus

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Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activity

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the ketopantoate reductase family.

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Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

pantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function2-dehydropantoate 2-reductase activity

Inferred from electronic annotation. Source: EC

NADP or NADPH binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Putative 2-dehydropantoate 2-reductase
PRO_0000157313

Regions

Nucleotide binding7 – 126NADP By similarity

Sites

Active site1871Proton donor By similarity
Binding site1051NADP; via amide nitrogen By similarity
Binding site1051Substrate By similarity
Binding site1911Substrate By similarity
Binding site1951Substrate By similarity
Binding site2601Substrate By similarity
Binding site2731NADP By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9CFY8-1 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 1C7FC4547F081BAD

FASTA31234,444
        10         20         30         40         50         60 
MRITIAGAGA MGSRFGLMLH KGGNEVTLID GWPEHVKAIK EHGLRANYNG EELTAHLSVE 

        70         80         90        100        110        120 
LQSEISSKEK TDLIILFTKA MQLDKMLQDI KPLIDEHTKV LCLLNGIGHE DTIEKYVSKN 

       130        140        150        160        170        180 
NIFIGNTMWT AGLEGPGKAK LFGDGSVELQ NLISGEEETA KKLAEILSES GLNAKYSNNI 

       190        200        210        220        230        240 
HYSIYRKACV NGTMNGLCTI LDTNMAGLGE TKPAHDMVVT IVNEFAAVAK FENVNLDIAE 

       250        260        270        280        290        300 
VVQHVETCFD PSTIGLHYPS MYQDLIKNNR LTEIDYINGA VSRKGKKYNV ATPYCDFLTQ 

       310 
LVHSKEELLK AK

« Hide

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References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed: 11337471] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005176 Genomic DNA. Translation: AAK05421.1.
PIRC86790.
RefSeqNP_267479.1.

3D structure databases

SMRQ9CFY8. Positions 1-312.
ModBaseSearch...

Genome annotation databases

GeneID1114972.
GenomeReviewsGene locus LL1323 in contig AE005176_GR.
KEGGlla:L157055.
NMPDRfig|272623.1.peg.1358.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG668370.
OMAIDSWQEH.

Enzyme and pathway databases

BioCycLLAC272623:L157055-MONOMER.
BRENDA1.1.1.169. 278870.

Family and domain databases

InterProIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013752. ApbA_C.
IPR013332. ApbA_N.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
PANTHERPTHR21708:SF21. ApbA. 1 hit.
PfamPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
TIGRFAMsTIGR00745. apbA_panE. 1 hit.
ProtoNetSearch...

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Entry information

Entry namePANE_LACLA
AccessionPrimary (citable) accession number: Q9CFY8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: June 1, 2001
Last modified: February 9, 2010
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents