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Q9CFY8

- PANE_LACLA

UniProt

Q9CFY8 - PANE_LACLA

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Protein
Putative 2-dehydropantoate 2-reductase
Gene
LL1323, L157055
Organism
Lactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei105 – 1051NADP; via amide nitrogen By similarity
Binding sitei105 – 1051Substrate By similarity
Active sitei187 – 1871Proton donor By similarity
Binding sitei191 – 1911Substrate By similarity
Binding sitei195 – 1951Substrate By similarity
Binding sitei260 – 2601Substrate By similarity
Binding sitei273 – 2731NADP By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADP By similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciLLAC272623:GHSH-1411-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Ordered Locus Names:LL1323
ORF Names:L157055
OrganismiLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis)
Taxonomic identifieri272623 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus
ProteomesiUP000002196: Chromosome

Subcellular locationi

Cytoplasm Reviewed prediction

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 312312Putative 2-dehydropantoate 2-reductase
PRO_0000157313Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi272623.L157055.

Structurei

3D structure databases

ProteinModelPortaliQ9CFY8.
SMRiQ9CFY8. Positions 1-312.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1893.
HOGENOMiHOG000050222.
KOiK00077.
OMAiMGLEPML.
OrthoDBiEOG6P5ZHG.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9CFY8-1 [UniParc]FASTAAdd to Basket

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MRITIAGAGA MGSRFGLMLH KGGNEVTLID GWPEHVKAIK EHGLRANYNG    50
EELTAHLSVE LQSEISSKEK TDLIILFTKA MQLDKMLQDI KPLIDEHTKV 100
LCLLNGIGHE DTIEKYVSKN NIFIGNTMWT AGLEGPGKAK LFGDGSVELQ 150
NLISGEEETA KKLAEILSES GLNAKYSNNI HYSIYRKACV NGTMNGLCTI 200
LDTNMAGLGE TKPAHDMVVT IVNEFAAVAK FENVNLDIAE VVQHVETCFD 250
PSTIGLHYPS MYQDLIKNNR LTEIDYINGA VSRKGKKYNV ATPYCDFLTQ 300
LVHSKEELLK AK 312
Length:312
Mass (Da):34,444
Last modified:June 1, 2001 - v1
Checksum:i1C7FC4547F081BAD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05421.1.
PIRiC86790.
RefSeqiNP_267479.1. NC_002662.1.

Genome annotation databases

EnsemblBacteriaiAAK05421; AAK05421; L157055.
GeneIDi1114972.
KEGGilla:L157055.
PATRICi22295038. VBILacLac136773_1427.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE005176 Genomic DNA. Translation: AAK05421.1 .
PIRi C86790.
RefSeqi NP_267479.1. NC_002662.1.

3D structure databases

ProteinModelPortali Q9CFY8.
SMRi Q9CFY8. Positions 1-312.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 272623.L157055.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAK05421 ; AAK05421 ; L157055 .
GeneIDi 1114972.
KEGGi lla:L157055.
PATRICi 22295038. VBILacLac136773_1427.

Phylogenomic databases

eggNOGi COG1893.
HOGENOMi HOG000050222.
KOi K00077.
OMAi MGLEPML.
OrthoDBi EOG6P5ZHG.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00004 .
BioCyci LLAC272623:GHSH-1411-MONOMER.

Family and domain databases

Gene3Di 1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProi IPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view ]
SUPFAMi SSF48179. SSF48179. 1 hit.
TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
    Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
    Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IL1403.

Entry informationi

Entry nameiPANE_LACLA
AccessioniPrimary (citable) accession number: Q9CFY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: June 1, 2001
Last modified: September 3, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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