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Q9CFY8 (PANE_LACLA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative 2-dehydropantoate 2-reductase

EC=1.1.1.169
Alternative name(s):
Ketopantoate reductase
Short name=KPA reductase
Short name=KPR
Gene names
Ordered Locus Names:LL1323
ORF Names:L157055
OrganismLactococcus lactis subsp. lactis (strain IL1403) (Streptococcus lactis) [Reference proteome] [HAMAP]
Taxonomic identifier272623 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeLactococcus

Protein attributes

Sequence length312 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid By similarity.

Catalytic activity

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the ketopantoate reductase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2-dehydropantoate 2-reductase activity

Inferred from electronic annotation. Source: UniProtKB-EC

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 312312Putative 2-dehydropantoate 2-reductase
PRO_0000157313

Regions

Nucleotide binding7 – 126NADP By similarity

Sites

Active site1871Proton donor By similarity
Binding site1051NADP; via amide nitrogen By similarity
Binding site1051Substrate By similarity
Binding site1911Substrate By similarity
Binding site1951Substrate By similarity
Binding site2601Substrate By similarity
Binding site2731NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9CFY8 [UniParc].

Last modified June 1, 2001. Version 1.
Checksum: 1C7FC4547F081BAD

FASTA31234,444
        10         20         30         40         50         60 
MRITIAGAGA MGSRFGLMLH KGGNEVTLID GWPEHVKAIK EHGLRANYNG EELTAHLSVE 

        70         80         90        100        110        120 
LQSEISSKEK TDLIILFTKA MQLDKMLQDI KPLIDEHTKV LCLLNGIGHE DTIEKYVSKN 

       130        140        150        160        170        180 
NIFIGNTMWT AGLEGPGKAK LFGDGSVELQ NLISGEEETA KKLAEILSES GLNAKYSNNI 

       190        200        210        220        230        240 
HYSIYRKACV NGTMNGLCTI LDTNMAGLGE TKPAHDMVVT IVNEFAAVAK FENVNLDIAE 

       250        260        270        280        290        300 
VVQHVETCFD PSTIGLHYPS MYQDLIKNNR LTEIDYINGA VSRKGKKYNV ATPYCDFLTQ 

       310 
LVHSKEELLK AK 

« Hide

References

[1]"The complete genome sequence of the lactic acid bacterium Lactococcus lactis ssp. lactis IL1403."
Bolotin A., Wincker P., Mauger S., Jaillon O., Malarme K., Weissenbach J., Ehrlich S.D., Sorokin A.
Genome Res. 11:731-753(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: IL1403.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE005176 Genomic DNA. Translation: AAK05421.1.
PIRC86790.
RefSeqNP_267479.1. NC_002662.1.

3D structure databases

ProteinModelPortalQ9CFY8.
SMRQ9CFY8. Positions 1-312.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272623.L157055.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK05421; AAK05421; L157055.
GeneID1114972.
KEGGlla:L157055.
PATRIC22295038. VBILacLac136773_1427.

Phylogenomic databases

eggNOGCOG1893.
HOGENOMHOG000050222.
KOK00077.
OMAMGLEPML.
OrthoDBEOG6P5ZHG.

Enzyme and pathway databases

BioCycLLAC272623:GHSH-1411-MONOMER.
UniPathwayUPA00028; UER00004.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013752. ApbA_C.
IPR013332. ApbA_N.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00745. apbA_panE. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANE_LACLA
AccessionPrimary (citable) accession number: Q9CFY8
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: June 1, 2001
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways